دورية أكاديمية
The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2'-Deoxyuridine and Tubercidin Analogues.
العنوان: | The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2'-Deoxyuridine and Tubercidin Analogues. |
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المؤلفون: | Aldfer MM; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Alfayez IA; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Elati HAA; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Gayen N; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Elmahallawy EK; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.; Department of Zoonoses, Faculty of Veterinary Medicine, Sohag University, Sohag 82524, Egypt., Milena Murillo A; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil., Marsiccobetre S; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil., Van Calenbergh S; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, B-9000 Gent, Belgium., Silber AM; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil., de Koning HP; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. |
المصدر: | Molecules (Basel, Switzerland) [Molecules] 2022 Nov 19; Vol. 27 (22). Date of Electronic Publication: 2022 Nov 19. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
مواضيع طبية MeSH: | Trypanosoma cruzi* , Chagas Disease*/drug therapy, Humans ; Nucleoside Transport Proteins ; Tubercidin ; Biological Transport ; Deoxyuridine |
مستخلص: | Among the scarce validated drug targets against Chagas disease (CD), caused by Trypanosoma cruzi , the parasite's nucleoside salvage system has recently attracted considerable attention. Although the trypanocidal activity of tubercidin (7-deazapurine) has long been known, the identification of a class of 7-substituted tubercidin analogs with potent in vitro and in vivo activity and much-enhanced selectivity has made nucleoside analogs among the most promising lead compounds against CD. Here, we investigate the recently identified TcrNT2 nucleoside transporter and its potential role in antimetabolite chemotherapy. TcrNT2, expressed in a Leishmania mexicana cell line lacking the NT1 nucleoside transporter locus, displayed very high selectivity and affinity for thymidine with a K |
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معلومات مُعتمدة: | Studentships to M.A.A. and H.A..A.E. Covernment of Libya; MR/P027989/1 United Kingdom MRC_ Medical Research Council; Newton Research Travel Grant Royal Society; Daniel Turnberg Fellowship United Kingdom AMS_ Academy of Medical Sciences; studentship to I.A.A. Saudi Arabia Ministry of Health |
فهرسة مساهمة: | Keywords: 5-F-2′-deoxyuridine; TcrNT2; Trypanosoma cruzi; antimetabolite; nucleoside transporter; pyrimidine transporter; thymidine; tubercidin analog |
المشرفين على المادة: | 0 (Nucleoside Transport Proteins) M351LCX45Y (Tubercidin) W78I7AY22C (Deoxyuridine) |
تواريخ الأحداث: | Date Created: 20221126 Date Completed: 20221129 Latest Revision: 20230222 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9693223 |
DOI: | 10.3390/molecules27228045 |
PMID: | 36432150 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1420-3049 |
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DOI: | 10.3390/molecules27228045 |