دورية أكاديمية
أعرض في EDS

Alveolar macrophage metabolic programming via a C-type lectin receptor protects against lipo-toxicity and cell death.

التفاصيل البيبلوغرافية
العنوان: Alveolar macrophage metabolic programming via a C-type lectin receptor protects against lipo-toxicity and cell death.
المؤلفون: Scur M; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Mahmoud AB; College of Applied Medical Science, Taibah University, Madina, Saudi Arabia., Dey S; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Abdalbarri F; Department of Pathology, McGill University, Montreal, QC, Canada., Stylianides I; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Medina-Luna D; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Beatrice Hunter Cancer Research Institute, Halifax, NS, Canada., Gamage GS; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Woblistin A; Department of Biochemistry, Dalhousie University, Halifax, NS, Canada., Wilson ANM; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Zein HS; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Immunology Research Program, King Abdullah International Medical Research Centre, Riyadh, Saudi Arabia., Stueck A; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Wight A; Department of Immunology, Dana-Farber Cancer Institute, Boston, MA, USA., Aguilar OA; Department of Microbiology and Immunology, University of California, San Francisco, USA., Di Cara F; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Parsons BD; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Rahim MMA; Department of Biomedical Sciences, University of Windsor, Windsor, ON, Canada., Carlyle JR; Department of Immunology, University of Toronto, Toronto, ON, Canada., Makrigiannis AP; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada. Andrew.Makrigiannis@dal.ca.; Beatrice Hunter Cancer Research Institute, Halifax, NS, Canada. Andrew.Makrigiannis@dal.ca.
المصدر: Nature communications [Nat Commun] 2022 Nov 25; Vol. 13 (1), pp. 7272. Date of Electronic Publication: 2022 Nov 25.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Pulmonary Alveolar Proteinosis*/metabolism , Pulmonary Surfactants*/metabolism, Mice ; Animals ; Macrophages, Alveolar/metabolism ; Lectins, C-Type/genetics ; Lectins, C-Type/metabolism ; Cell Death
مستخلص: Alveolar macrophages (AM) hold lung homeostasis intact. In addition to the defense against inhaled pathogens and deleterious inflammation, AM also maintain pulmonary surfactant homeostasis, a vital lung function that prevents pulmonary alveolar proteinosis. Signals transmitted between AM and pneumocytes of the pulmonary niche coordinate these specialized functions. However, the mechanisms that guide the metabolic homeostasis of AM remain largely elusive. We show that the NK cell-associated receptor, NKR-P1B, is expressed by AM and is essential for metabolic programming. Nkrp1b -/- mice are vulnerable to pneumococcal infection due to an age-dependent collapse in the number of AM and the formation of lipid-laden AM. The AM of Nkrp1b -/- mice show increased uptake but defective metabolism of surfactant lipids. We identify a physical relay between AM and alveolar type-II pneumocytes that is dependent on pneumocyte Clr-g expression. These findings implicate the NKR-P1B:Clr-g signaling axis in AM-pneumocyte communication as being important for maintaining metabolism in AM.
(© 2022. The Author(s).)
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المشرفين على المادة: 0 (Lectins, C-Type)
0 (Pulmonary Surfactants)
تواريخ الأحداث: Date Created: 20221126 Date Completed: 20221129 Latest Revision: 20221228
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC9700784
DOI: 10.1038/s41467-022-34935-w
PMID: 36433992
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-022-34935-w