دورية أكاديمية
Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site.
| العنوان: | Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site. |
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| المؤلفون: | Muresan P; School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK., McCrorie P; Children's Brain Tumour Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, NG7 2RD, UK., Smith F; School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK., Vasey C; School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK., Taresco V; School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK., Scurr DJ; Nanoscale and Microscale Research Centre, University of Nottingham, Nottingham NG7 2RD, UK., Kern S; Nanoscale and Microscale Research Centre, University of Nottingham, Nottingham NG7 2RD, UK., Smith S; Children's Brain Tumour Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, NG7 2RD, UK., Gershkovich P; School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK., Rahman R; Children's Brain Tumour Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, NG7 2RD, UK., Marlow M; School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK. Electronic address: maria.marlow@nottingham.ac.uk. |
| المصدر: | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2023 Jan; Vol. 182, pp. 53-61. Date of Electronic Publication: 2022 Nov 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9109778 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3441 (Electronic) Linking ISSN: 09396411 NLM ISO Abbreviation: Eur J Pharm Biopharm Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Science Original Publication: Stuttgart : Wissenschaftliche Verlagsgesellschaft, c1991- |
| مواضيع طبية MeSH: | Nanoparticles*/chemistry , Glioblastoma* , Brain Neoplasms*/drug therapy, Animals ; Rats ; Sepharose ; Drug Delivery Systems/methods ; Brain ; Needles ; Administration, Cutaneous |
| مستخلص: | Systemic drug delivery to the central nervous system (CNS) has been historically impeded by the presence of the blood brain barrier rendering many therapies inefficacious to any cancer cells residing within the brain. Therefore, local drug delivery systems are being developed to overcome this shortfall. Here we have manufactured polymeric microneedle (MN) patches, which can be anchored within a resection cavity site following surgical removal of a tumour such as isocitrate dehydrogenase wild type glioblastoma (GBM). These MN patches have been loaded with polymer coated nanoparticles (NPs) containing cannabidiol (CBD) or olaparib (OLA) and applied to an in vitro brain simulant and ex vivo rat brain tissue to assess drug release and distance of penetration. MN patches loaded with methylene blue dye were placed into a cavity of 0.6 % agarose to simulate brain tissue. The results showed that clear channels were generated by the MNs and the dye spread laterally throughout the agarose. When loaded with CBD-NPs, the agarose showed a CBD concentration of 12.5 µg/g at 0.5 cm from the MN insertion site. Furthermore, high performance liquid chromatography of ex vivo brain tissue following CBD-NP/MN patch insertion showed successful delivery of 59.6 µg/g into the brain tissue. Similarly, OLA-NP loaded MN patches showed delivery of 5.2 µg/g OLA into agarose gel at 0.5 cm distance from the insertion site. Orbitrap secondary ion mass spectrometry (OrbiSIMS) analysis confirmed the presence of OLA and the MN patch at up to 6 mm away from the insertion site following its application to a rat brain hemisphere. This data has provided insight into the capabilities and versatility of MN patches for use in local brain drug delivery, giving promise for future research. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Isocitrate dehydrogenase wild type glioblastoma; Microneedles; Nanoparticles |
| المشرفين على المادة: | 9012-36-6 (Sepharose) |
| تواريخ الأحداث: | Date Created: 20221126 Date Completed: 20230120 Latest Revision: 20230120 |
| رمز التحديث: | 20230120 |
| DOI: | 10.1016/j.ejpb.2022.11.016 |
| PMID: | 36435313 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3441 |
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| DOI: | 10.1016/j.ejpb.2022.11.016 |