دورية أكاديمية
أعرض في EDS

Thiazolidin-4-one prevents against memory deficits, increase in phosphorylated tau protein, oxidative damage and cholinergic dysfunction in Alzheimer disease model: Comparison with donepezil drug.

التفاصيل البيبلوغرافية
العنوان: Thiazolidin-4-one prevents against memory deficits, increase in phosphorylated tau protein, oxidative damage and cholinergic dysfunction in Alzheimer disease model: Comparison with donepezil drug.
المؤلفون: Dos Santos A; Program in Biochemistry and Bioprospection, Laboratory of Neurochemistry, Inflammation and Cancer, Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, University Campus, Pelotas, RS, Brazil., Teixeira FC; Program in Biochemistry and Bioprospection, Laboratory of Neurochemistry, Inflammation and Cancer, Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, University Campus, Pelotas, RS, Brazil., da Silva DS; Program in Biochemistry and Bioprospecting, Laboratory of Chemistry Applied to Bioactives, Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, University Campus S/N, Pelotas, RS, Brazil., Veleda TA; Program in Biochemistry and Bioprospecting, Laboratory of Biomarkers, Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, University Campus, S/N, Pelotas, RS, Brazil., de Mello JE; Program in Biochemistry and Bioprospection, Laboratory of Neurochemistry, Inflammation and Cancer, Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, University Campus, Pelotas, RS, Brazil., Luduvico KP; Program in Biochemistry and Bioprospecting, Laboratory of Biomarkers, Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, University Campus, S/N, Pelotas, RS, Brazil., Tavares RG; Program in Biochemistry and Bioprospecting, Laboratory of Biomarkers, Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, University Campus, S/N, Pelotas, RS, Brazil., Stefanello FM; Program in Biochemistry and Bioprospecting, Laboratory of Biomarkers, Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, University Campus, S/N, Pelotas, RS, Brazil., Cunico W; Program in Biochemistry and Bioprospecting, Laboratory of Chemistry Applied to Bioactives, Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, University Campus S/N, Pelotas, RS, Brazil., Spanevello RM; Program in Biochemistry and Bioprospection, Laboratory of Neurochemistry, Inflammation and Cancer, Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, University Campus, Pelotas, RS, Brazil. Electronic address: roselia.spanevello@ufpel.edu.br.
المصدر: Brain research bulletin [Brain Res Bull] 2023 Feb; Vol. 193, pp. 1-10. Date of Electronic Publication: 2022 Nov 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res Bull Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Elsevier Science
Original Publication: Phoenix, N. Y. ANKHO International Inc.
مواضيع طبية MeSH: Alzheimer Disease*/metabolism, Rats ; Male ; Animals ; Donepezil/pharmacology ; Donepezil/therapeutic use ; tau Proteins/metabolism ; Streptozocin/toxicity ; Acetylcholinesterase/metabolism ; Oxidative Stress ; Memory Disorders/drug therapy ; Memory Disorders/prevention & control ; Memory Disorders/chemically induced ; Antioxidants/pharmacology ; Cholinesterase Inhibitors/pharmacology ; Disease Models, Animal ; Maze Learning
مستخلص: Alzheimer's disease (AD) is characterized mostly by memory decline. The current therapeutic arsenal for treating AD is limited, and the available drugs only produce symptomatic benefits, but do not stop disease progression. The search for effective therapeutic alternatives with multitarget actions is therefore imperative. One such a potential alternative is thiazolidin-4-one, a compound that exhibits anti-amnesic, anticholinesterase, and antioxidant activities. The aim of this study was evaluated the effects of 2-(4-(methylthio)phenyl)- 3-(3-(piperidin-1-yl)propyl) thiazolidin-4-one (DS12) on memory and neurochemical parameters in a model of AD induced by an intracerebroventricular injection of streptozotocin (STZ). Adult male rats were divided into five groups: I, control (saline); II, DS12 (10 mg/kg); III, STZ; IV, STZ + DS12 (10 mg/kg); V, STZ + donepezil (5 mg/kg). The rats were orally treated with DS12 and donepezil for a period of 20 days. Memory, acetylcholinesterase (AChE) activity, phosphorylated tau protein levels and oxidative stress were analyzed in the cerebral cortex, hippocampus, and cerebellum. Biochemical and hematological parameters were evaluated in the blood and serum. Memory impairment and the increase in AChE activity and phosphorylated tau protein level induced by STZ were prevented by DS12 and donepezil treatment. Streptozotocin induces an increase in reactive oxygen species levels and a decrease in catalase activity in the hippocampus, cerebral cortex, and cerebellum. DS12 treatment conferred protection from oxidative alterations in all brain structures. No changes were observed in serum biochemical parameters (glucose, triglycerides, cholesterol, uric acid, and urea) or hematological parameters, such as platelets, lymphocytes, hemoglobin, hematocrit, and total plasma protein. DS12 improved memory and neurochemical changes in an AD model and did not show toxic effects, suggesting the promising therapeutic potential of this compound.
Competing Interests: Conflicts of interest The authors declare that there are no conflicts of interest.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Acetylcholinesterase; Alzheimer’s disease; Brain; Oxidative stress; Tau protein; Thiazolidin-4-ones
المشرفين على المادة: 8SSC91326P (Donepezil)
0 (tau Proteins)
5W494URQ81 (Streptozocin)
EC 3.1.1.7 (Acetylcholinesterase)
0 (Antioxidants)
0 (Cholinesterase Inhibitors)
تواريخ الأحداث: Date Created: 20221128 Date Completed: 20230124 Latest Revision: 20230201
رمز التحديث: 20240628
DOI: 10.1016/j.brainresbull.2022.11.015
PMID: 36442692
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2747
DOI:10.1016/j.brainresbull.2022.11.015