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Biochemical and Structural Insights into FIH-Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains.

التفاصيل البيبلوغرافية
العنوان: Biochemical and Structural Insights into FIH-Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains.
المؤلفون: Saward BG; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK., Leissing TM; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK., Clifton IJ; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK., Tumber A; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK., Timperley CM; CBR Division, Defence Science and Technology Laboratory (DSTL), Porton Down, Salisbury, SP4 0JQ, UK., Hopkinson RJ; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK.; Present address: Leicester Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK., Schofield CJ; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK.
المصدر: Chembiochem : a European journal of chemical biology [Chembiochem] 2023 Feb 14; Vol. 24 (4), pp. e202200576. Date of Electronic Publication: 2023 Jan 09.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH Verlag, c2000-
مواضيع طبية MeSH: Ankyrin Repeat* , Respiratory Distress Syndrome*, Humans ; Animals ; Repressor Proteins/metabolism ; Amino Acid Sequence ; Hydroxylation ; Mixed Function Oxygenases/metabolism ; Protein Binding ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
مستخلص: Transient receptor potential (TRP) channels have important roles in environmental sensing in animals. Human TRP subfamily A member 1 (TRPA1) is responsible for sensing allyl isothiocyanate (AITC) and other electrophilic sensory irritants. TRP subfamily vanilloid member 3 (TRPV3) is involved in skin maintenance. TRPV3 is a reported substrate of the 2-oxoglutarate oxygenase factor inhibiting hypoxia-inducible factor (FIH). We report biochemical and structural studies concerning asparaginyl hydroxylation of the ankyrin repeat domains (ARDs) of TRPA1 and TRPV3 catalysed by FIH. The results with ARD peptides support a previous report on FIH-catalysed TRPV3 hydroxylation and show that, of the 12 potential TRPA1 sequences investigated, one sequence (TRPA1 residues 322-348) undergoes hydroxylation at Asn336. Structural studies reveal that the TRPA1 and TRPV3 ARDs bind to FIH with a similar overall geometry to most other reported FIH substrates. However, the binding mode of TRPV3 to FIH is distinct from that of other substrates.
(© 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH.)
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معلومات مُعتمدة: United Kingdom WT_ Wellcome Trust; United Kingdom CRUK_ Cancer Research UK
فهرسة مساهمة: Keywords: ankyrin; factor inhibiting HIF (FIH); hypoxia inducible factor HIF; oxygenases, demethylases; post translational modifications; transient receptor potential (TRP) channel
المشرفين على المادة: 0 (Repressor Proteins)
EC 1.- (Mixed Function Oxygenases)
0 (Hypoxia-Inducible Factor 1, alpha Subunit)
تواريخ الأحداث: Date Created: 20221130 Date Completed: 20230215 Latest Revision: 20240320
رمز التحديث: 20240320
مُعرف محوري في PubMed: PMC10946520
DOI: 10.1002/cbic.202200576
PMID: 36448355
قاعدة البيانات: MEDLINE
الوصف
تدمد:1439-7633
DOI:10.1002/cbic.202200576