دورية أكاديمية
The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats.
| العنوان: | The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats. |
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| المؤلفون: | Costello HM; Department of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA.; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL 32610, USA., Juffre A; Department of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA.; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL 32610, USA.; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA., Cheng KY; Department of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA.; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL 32610, USA., Bratanatawira P; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL 32610, USA., Crislip GR; Department of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA.; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL 32610, USA., Zietara A; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33602, USA., Spires DR; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Staruschenko A; Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33602, USA.; James A. Haley Veterans' Hospital, Tampa, FL 33612, USA., Douma LG; Department of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA.; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL 32610, USA.; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA., Gumz ML; Department of Physiology and Aging, University of Florida, Gainesville, FL 32610, USA.; Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL 32610, USA.; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA.; Center for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, FL 32610, USA. |
| المصدر: | Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2023 Mar 01; Vol. 101 (3), pp. 136-146. Date of Electronic Publication: 2022 Nov 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 0372712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1205-7541 (Electronic) Linking ISSN: 00084212 NLM ISO Abbreviation: Can J Physiol Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : Ottawa, ON : Canadian Science Publishing Original Publication: Ottawa, National Research Council of Canada. |
| مواضيع طبية MeSH: | Circadian Clocks*/genetics , Hypertension*, Rats ; Mice ; Animals ; Rats, Inbred Dahl ; Endothelins ; Kidney/metabolism ; Endothelin-1/genetics ; Endothelin-1/metabolism ; Transcription Factors/metabolism ; Blood Pressure/physiology ; Period Circadian Proteins/genetics |
| مستخلص: | Endothelin-1 (ET-1) is a peptide hormone that acts on its receptors to regulate sodium handling in the kidney's collecting duct. Dysregulation of the endothelin axis is associated with various diseases, including salt-sensitive hypertension and chronic kidney disease. Previously, our lab has shown that the circadian clock gene PER1 regulates ET-1 levels in mice. However, the regulation of ET-1 by PER1 has never been investigated in rats. Therefore, we used a novel model where knockout of Per1 was performed in Dahl salt-sensitive rat background (SS Per1 -/- ) to test a hypothesis that PER1 regulates the ET-1 axis in this model. Here, we show increased renal ET-1 peptide levels and altered endothelin axis gene expression in several tissues, including the kidney, adrenal glands, and liver in SS Per1 -/- compared with control SS rats. Edn1 antisense lncRNA Edn1-AS , which has previously been suggested to be regulated by PER1, was also altered in SS Per1 -/- rats compared with control SS rats. These data further support the hypothesis that PER1 is a negative regulator of Edn1 and is important in the regulation of the endothelin axis in a tissue-specific manner. |
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| معلومات مُعتمدة: | I01 BX004024 United States BX BLRD VA; R01 DK109570 United States DK NIDDK NIH HHS; R35 HL135749 United States HL NHLBI NIH HHS; R56 DK128271 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: ET-1; Period1; adrenal glands; endothelin-1; kidney; salt-sensitive hypertension |
| المشرفين على المادة: | 0 (Endothelins) 0 (Endothelin-1) 0 (Transcription Factors) 0 (Per1 protein, mouse) 0 (Period Circadian Proteins) 0 (Per1 protein, rat) |
| تواريخ الأحداث: | Date Created: 20221130 Date Completed: 20230302 Latest Revision: 20240302 |
| رمز التحديث: | 20240302 |
| مُعرف محوري في PubMed: | PMC9992312 |
| DOI: | 10.1139/cjpp-2022-0134 |
| PMID: | 36450128 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1205-7541 |
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| DOI: | 10.1139/cjpp-2022-0134 |