دورية أكاديمية
Evaluation of the toxicity of crude aqueous Pleurotus tuber-regium (Fr.) Singer extract in mice.
| العنوان: | Evaluation of the toxicity of crude aqueous Pleurotus tuber-regium (Fr.) Singer extract in mice. |
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| المؤلفون: | Edoh SP; Department of Zoology, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Nigeria., Sani D; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria., Mbah CE; Department of Zoology, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Nigeria., Yusuf H; Department of Microbiology and Biotechnology, Federal University, Dutse, Nigeria., Jolayemi KO; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria., Ibrahim MK; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria. |
| المصدر: | Journal of complementary & integrative medicine [J Complement Integr Med] 2022 Dec 01; Vol. 20 (1), pp. 106-111. Date of Electronic Publication: 2022 Dec 01 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 101313855 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-3840 (Electronic) Linking ISSN: 15533840 NLM ISO Abbreviation: J Complement Integr Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2012-> : Berlin : Walter de Gruyter Original Publication: Berkeley, Calif. : Berkeley Electronic Press, 2004- |
| مواضيع طبية MeSH: | Pleurotus*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/toxicity, Animals ; Mice ; Phytochemicals/analysis |
| مستخلص: | Objectives: The study aimed to determine the phytochemical profile and safety of the aqueous extract of Pleurotus tuber regium using laboratory animal model. Methods: The pulverized sample was macerated with water and allowed to stand for 24 h, then filtered. Preliminary qualitative phytochemical screening was carried out on the crude extract and LD Results: The phytochemical screening revealed the presence of alkaloids, cardiac glycosides, saponins, phenolic compounds, tannins, steroids, carbohydrates, flavonoids and terpenoids. However, anthraquinones were observed to be absent in the extracts. The LD Conclusions: This study showed that P. tuber-regium (Fr.) Singer does not possess toxic principles, hence, the wide safety margin observed in the mice. (© 2022 Walter de Gruyter GmbH, Berlin/Boston.) |
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| فهرسة مساهمة: | Keywords: Pleurotus tuber-regium; acute oral toxicity; haematology; histopathology; mice |
| المشرفين على المادة: | 0 (Plant Extracts) 0 (Phytochemicals) |
| SCR Organism: | Pleurotus tuber-regium |
| تواريخ الأحداث: | Date Created: 20221130 Date Completed: 20231223 Latest Revision: 20231223 |
| رمز التحديث: | 20231223 |
| DOI: | 10.1515/jcim-2022-0306 |
| PMID: | 36450279 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1553-3840 |
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| DOI: | 10.1515/jcim-2022-0306 |