دورية أكاديمية
أعرض في EDS

Prevalence of 13 polyomaviruses in actinic keratosis and matched healthy skin samples of immunocompetent individuals.

التفاصيل البيبلوغرافية
العنوان: Prevalence of 13 polyomaviruses in actinic keratosis and matched healthy skin samples of immunocompetent individuals.
المؤلفون: Donà MG; STI/HIV Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy., Gheit T; International Agency for Research on Cancer, World Health Organization, Lyon, France., Chiantore MV; EVOR Unit, Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy., Vescio MF; Epidemiology Unit, Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy., Luzi F; Plastic and Reconstructive Surgery, San Gallicano Dermatologic Institute IRCCS, Rome, Italy., Rollo F; Pathology Department, Regina Elena National Cancer Institute, IRCCS, Rome, Italy., Accardi L; EVOR Unit, Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy., Cota C; Department of Dermopathology, San Gallicano Dermatological Institute IRCCS, Rome, Italy., Galati L; International Agency for Research on Cancer, World Health Organization, Lyon, France., Romeo G; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome-Polo Pontino, Latina, Italy., Giuliani M; STI/HIV Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy., Tommasino M; IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Di Bonito P; EVOR Unit, Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy. paola.dibonito@iss.it.
المصدر: Infectious agents and cancer [Infect Agent Cancer] 2022 Dec 01; Vol. 17 (1), pp. 59. Date of Electronic Publication: 2022 Dec 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101276559 Publication Model: Electronic Cited Medium: Print ISSN: 1750-9378 (Print) Linking ISSN: 17509378 NLM ISO Abbreviation: Infect Agent Cancer Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2006-
مستخلص: Background: Actinic keratosis (AK) is a precursor of cutaneous squamous cell carcinoma (cSCC). UV radiation is the major risk factor for AK, but certain human papillomaviruses (HPVs) of the beta genus are also involved in its development. Differently, the role of polyomaviruses (PyVs) in skin carcinogenesis is still debated. Fiftheen PyVs have been isolated from human tissues so far, including Merkel cell polyomavirus (MCPyV), the aetiological agent of Merkel cell carcinoma.
Methods: The presence of 13 PyVs was assessed in skin samples from AK patients (n = 342). Matched fresh-frozen scrapings from healthy skin (HS) and AK lesions from 242 patients, and formalin-fixed paraffin-embedded AK biopsies from a different cohort of 100 patients were analyzed by multiplex PyVs genotyping assay.
Results: The most frequent lesion site was the scalp in men (27.3%), and the cheek area in women (29.0%). Differences between men and women were significant for the scalp, the cheek area and the lips. Almost all the scrapings were PyV-positive (HS: 89.7%, AK: 94.6%; p = 0.04). The three most frequent PyVs were MCPyV, HPyV6 and JCPyV (HS: 87.2%, 58.7%, 6.6%, respectively; AK: 88.8%, 51.2%, 9.9%, respectively). HPyV9, TSPyV, BKPyV, HPyV7, LIPyV and SV40 were detected in < 2% of the scrapings. In most cases, matched HS and AK scrapings were both positive (MCPyV: 78.1%, HPyV6: 41.7%), or both negative for the individual genotypes (for the remaining PyVs). PyV prevalence in AK biopsies was 22.0%. Only MCPyV (21.0%) and HPyV6 (3.0%) were detected in these samples.
Conclusions: PyV prevalence in HS and AK scrapings was high, but detection of PyVs exclusively in AK scrapings was rare. PyV positivity rate in AK biopsies was modest. Further research is need to reach firm conclusions regarding the role of these viruses in AK development.
(© 2022. The Author(s).)
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معلومات مُعتمدة: 001 International WHO_ World Health Organization
فهرسة مساهمة: Keywords: Actinic keratosis; Luminex-based HPyV assay; Oncoviruses; Polyomaviruses
تواريخ الأحداث: Date Created: 20221202 Latest Revision: 20240324
رمز التحديث: 20240324
مُعرف محوري في PubMed: PMC9714215
DOI: 10.1186/s13027-022-00472-w
PMID: 36457033
قاعدة البيانات: MEDLINE
الوصف
تدمد:1750-9378
DOI:10.1186/s13027-022-00472-w