دورية أكاديمية
Preliminary Analysis of the Glycolipid Profile in Secondary Brain Tumors.
| العنوان: | Preliminary Analysis of the Glycolipid Profile in Secondary Brain Tumors. |
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| المؤلفون: | Serb AF; Victor Babes University of Medicine and Pharmacy Timisoara, Biochemistry and Pharmacology Department, Biochemistry Discipline, Eftimie Murgu Sq. no. 2, 300041, Timisoara, Romania., Novaconi C; Victor Babes University of Medicine and Pharmacy Timisoara, Faculty of Medicine, Eftimie Murgu Sq. no. 2, 300041, Timisoara, Romania., Georgescu M; Victor Babes University of Medicine and Pharmacy Timisoara, Functional Sciences Department, Physiology Discipline, Eftimie Murgu Sq. no. 2, 300041, Timisoara, Romania.; Center of Immuno-Physiology and Biotechnologies (CIFBIOTEH), 'Victor Babeș' University of Medicine and Pharmacy Timișoara, Eftimie Murgu Sq. no. 2, 300041 Timișoara, Romania., Puiu M; Victor Babes University of Medicine and Pharmacy Timisoara, Functional Sciences Department, Genetics Discipline, Eftimie Murgu Sq. no. 2, 300041, Timisoara, Romania., Dema A; Victor Babes University of Medicine and Pharmacy Timisoara, Functional Sciences Department, Morphopathology Discipline, Eftimie Murgu Sq. no. 2, 300041, Timisoara, Romania., Onulov R; Victor Babes University of Medicine and Pharmacy Timisoara, Faculty of Medicine, Eftimie Murgu Sq. no. 2, 300041, Timisoara, Romania., Sisu E; Victor Babes University of Medicine and Pharmacy Timisoara, Biochemistry and Pharmacology Department, Biochemistry Discipline, Eftimie Murgu Sq. no. 2, 300041, Timisoara, Romania. |
| المصدر: | BioMed research international [Biomed Res Int] 2022 Nov 22; Vol. 2022, pp. 4293172. Date of Electronic Publication: 2022 Nov 22 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Hindawi Pub. Co. |
| مواضيع طبية MeSH: | Glycolipids* , Brain Neoplasms*, Humans ; Brain ; Carcinogenesis ; Tropism |
| مستخلص: | Glycosphingolipids (GSLs) play numerous roles in cellular processes, including cell proliferation, apoptosis, inflammation, and cell signaling. Alteration of the GSLs metabolism leads to the accumulation of particular species of GSLs, which can lead to various pathologies, including carcinogenesis and metastasis; in essence, all neoplasms are characterized by the synthesis and aberrant organization of GSLs expressed on the cell surface. Secondary brain tumors make up the majority of intracranial cancers and generally present an unfavorable prognosis. In the present work, a native GSL mixture extracted and purified from a secondary brain tumor with primary pulmonary origin was obtained through extraction and purification and analyzed by MALDI TOF mass spectrometry. Research in the field of lipidomics could offer new data for the understanding of brain tropism and metastatic pathways, by studying the glycolipid molecules involved in the process of metastasis in general and in the production of brain metastases in particular. This could shed new light on the pattern of lipid glycosylation in secondary brain tumors, with a great impact on the effectiveness of cancer therapies, which could be adapted to the specific molecular pattern of the tumor. Competing Interests: The authors declare no conflict of interest. (Copyright © 2022 Alina-Florina Serb et al.) |
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| المشرفين على المادة: | 0 (Glycolipids) |
| تواريخ الأحداث: | Date Created: 20221202 Date Completed: 20221205 Latest Revision: 20221205 |
| رمز التحديث: | 20221205 |
| مُعرف محوري في PubMed: | PMC9708355 |
| DOI: | 10.1155/2022/4293172 |
| PMID: | 36457344 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2314-6141 |
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| DOI: | 10.1155/2022/4293172 |