دورية أكاديمية
أعرض في EDS

MiR-146a and miR-155 polymorphisms in Egyptian patients with Behcet's disease.

التفاصيل البيبلوغرافية
العنوان: MiR-146a and miR-155 polymorphisms in Egyptian patients with Behcet's disease.
المؤلفون: Shaker OG; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt., Abdelaleem OO; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Faiyum, Egypt., Fouad NA; Department of Rheumatology and Rehabilitation, Faculty of Medicine, Fayoum University, Faiyum, Egypt., Ahmed NA; Department of Medical Physiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Hussein HA; Department of Internal Medicine, Faculty of Medicine, Fayoum University, Faiyum, Egypt., Ibrahem EG; Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Faiyum, Egypt., Mohamed AA; Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Faiyum, Egypt., Ahmed OM; Department of Clinical Pathology, Faculty of Medicine, Fayoum University, Faiyum, Egypt., Ali DY; Department of Clinical Pathology, Faculty of Medicine, Fayoum University, Faiyum, Egypt.
المصدر: Archives of medical science : AMS [Arch Med Sci] 2021 Mar 19; Vol. 18 (6), pp. 1467-1474. Date of Electronic Publication: 2021 Mar 19 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Termedia Pub. House Country of Publication: Poland NLM ID: 101258257 Publication Model: eCollection Cited Medium: Print ISSN: 1734-1922 (Print) Linking ISSN: 17341922 NLM ISO Abbreviation: Arch Med Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Poznań, Poland] : Termedia Pub. House, [2005]-
مستخلص: Introduction: The current study was designed to analyze whether polymorphisms of miR-146a and miR-155 are related to Behçet's disease (BD) in the Egyptian population.
Material and Methods: A total of 96 unrelated BD patients and 100 healthy subjects were genotyped for miR-146a (rs2910164) and miR-155 (rs767649) using real-time polymerase chain reaction.
Results: The results showed significant elevation in the frequency of rs2910164 GG and CC genotypes in BD patients compared with controls (adjusted OR = 22.156, 95% CI: 4.728-103.818; p < 0.001 and adjusted OR = 40.358, 95% CI: 8.928-182.440; p < 0.001, respectively). Also, the rs2910164 G allele conferred a higher risk of developing BD (adjusted OR = 3.665, 95% CI: 2.013-6.671; p < 0.001). MiR-146a (rs2910164) polymorphism was a risk factor for susceptibility to BD in dominant, recessive and additive models of inheritance (all p < 0.001), while the miR-155 (rs767649) polymorphism was a risk factor in the recessive model only ( p = 0.021). GG and CG genotypes of rs2910164 were associated with higher Behcet's disease current activity index (BDCAI) and ocular involvement compared with CC genotype ( p = 0.005 and p = 0.004, respectively). Genotype AT of rs767649 was related to higher BDCAI ( p = 0.026) compared with TT and AA genotypes.
Conclusions: miR-146a (rs2910164) and miR-155 (rs767649) are likely to play an important role in the Egyptian population in development of BD and also influence disease severity.
Competing Interests: The authors declare no conflict of interest.
(Copyright: © 2021 Termedia & Banach.)
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فهرسة مساهمة: Keywords: Behçet’s disease; miR-146a; miR-155; polymorphism
تواريخ الأحداث: Date Created: 20221202 Latest Revision: 20221203
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9710268
DOI: 10.5114/aoms/105349
PMID: 36457982
قاعدة البيانات: MEDLINE
الوصف
تدمد:1734-1922
DOI:10.5114/aoms/105349