دورية أكاديمية
أعرض في EDS

The skin is no barrier to mixtures: Air pollutant mixtures and reported psoriasis or eczema in the Personalized Environment and Genes Study (PEGS).

التفاصيل البيبلوغرافية
العنوان: The skin is no barrier to mixtures: Air pollutant mixtures and reported psoriasis or eczema in the Personalized Environment and Genes Study (PEGS).
المؤلفون: Lowe ME; National Institute of Environmental Health Sciences, Division of the National Toxicology Program, Durham, USA. melowe1216@gmail.com.; National Institute of Environmental Health Sciences, Clinical Research Branch, Durham, USA. melowe1216@gmail.com., Akhtari FS; National Institute of Environmental Health Sciences, Biostatistics and Computational Biology Branch, Durham, USA., Potter TA; National Institute of Environmental Health Sciences, Division of the National Toxicology Program, Durham, USA., Fargo DC; National Institute of Environmental Health Sciences, Division of the National Toxicology Program, Durham, USA., Schmitt CP; National Institute of Environmental Health Sciences, Office of Data Science, Durham, USA., Schurman SH; National Institute of Environmental Health Sciences, Clinical Research Branch, Durham, USA.; National Institute on Aging, Clinical Research Core, Bethesda, USA., Eccles KM; National Institute of Environmental Health Sciences, Division of the National Toxicology Program, Durham, USA., Motsinger-Reif A; National Institute of Environmental Health Sciences, Biostatistics and Computational Biology Branch, Durham, USA., Hall JE; National Institute of Environmental Health Sciences, Clinical Research Branch, Durham, USA., Messier KP; National Institute of Environmental Health Sciences, Division of the National Toxicology Program, Durham, USA.; National Institute of Environmental Health Sciences, Clinical Research Branch, Durham, USA.; National Institute of Environmental Health Sciences, Biostatistics and Computational Biology Branch, Durham, USA.; National Institute on Minority Health and Health Disparities, Bethesda, USA.
المصدر: Journal of exposure science & environmental epidemiology [J Expo Sci Environ Epidemiol] 2023 May; Vol. 33 (3), pp. 474-481. Date of Electronic Publication: 2022 Dec 02.
نوع المنشور: Journal Article; Research Support, N.I.H., Intramural
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101262796 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-064X (Electronic) Linking ISSN: 15590631 NLM ISO Abbreviation: J Expo Sci Environ Epidemiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Nature Pub. Group, c2006-
مواضيع طبية MeSH: Air Pollutants*/adverse effects , Air Pollutants*/analysis , Air Pollution*/adverse effects , Air Pollution*/analysis , Eczema*/chemically induced , Eczema*/epidemiology , Psoriasis*/chemically induced , Psoriasis*/epidemiology , Psoriasis*/genetics, Humans ; United States/epidemiology ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis
مستخلص: Background: Autoimmune (AI) diseases appear to be a product of genetic predisposition and environmental triggers. Disruption of the skin barrier causes exacerbation of psoriasis/eczema. Oxidative stress is a mechanistic pathway for pathogenesis of the disease and is also a primary mechanism for the detrimental effects of air pollution.
Methods: We evaluated the association between autoimmune skin diseases (psoriasis or eczema) and air pollutant mixtures in 9060 subjects from the Personalized Environment and Genes Study (PEGS) cohort. Pollutant exposure data on six criteria air pollutants are publicly available from the Center for Air, Climate, and Energy Solutions and the Atmospheric Composition Analysis Group. For increased spatial resolution, we included spatially cumulative exposure to volatile organic compounds from sites in the United States Environmental Protection Agency Toxic Release Inventory and the density of major roads within a 5 km radius of a participant's address from the United States Geological Survey. We applied logistic regression with quantile g-computation, adjusting for age, sex, diagnosis with an autoimmune disease in family or self, and smoking history to evaluate the relationship between self-reported diagnosis of an AI skin condition and air pollution mixtures.
Results: Only one air pollution variable, sulfate, was significant individually (OR = 1.06, p = 3.99E-2); however, the conditional odds ratio for the combined mixture components of PM 2.5 (black carbon, sulfate, sea salt, and soil), CO, SO 2 , benzene, toluene, and ethylbenzene is 1.10 (p-value = 5.4E-3).
Significance: While the etiology of autoimmune skin disorders is not clear, this study provides evidence that air pollutants are associated with an increased prevalence of these disorders. The results provide further evidence of potential health impacts of air pollution exposures on life-altering diseases.
Significance and Impact Statement: The impact of air pollution on non-pulmonary and cardiovascular diseases is understudied and under-reported. We find that air pollution significantly increased the odds of psoriasis or eczema in our cohort and the magnitude is comparable to the risk associated with smoking exposure. Autoimmune diseases like psoriasis and eczema are likely impacted by air pollution, particularly complex mixtures and our study underscores the importance of quantifying air pollution-associated risks in autoimmune disease.
(© 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
References: Pope CA III, Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, et al. Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation. 2004;109:71–77. (PMID: 1467614510.1161/01.CIR.0000108927.80044.7F)
Schwartz J, Slater D, Larson TV, Pierson WE, Koenig JO. Particulate air pollution and hospital emergency room. Am Rev Respir Dis. 1993;147:826–31. (PMID: 846611610.1164/ajrccm/147.4.826)
Bachmann J. Will the circle be unbroken: a history of the US National Ambient Air Quality Standards. J Air Waste Manag Assoc. 2007;57:652–97. (PMID: 1760800410.3155/1047-3289.57.6.652)
Lodovici M, Bigagli E. Oxidative stress and air pollution exposure. J Toxicol., 2011, 2011.
Khan MF, Wang G. Environmental agents, oxidative stress and autoimmunity. Curr Opin Toxicol. 2018;7:22–27. (PMID: 2953204010.1016/j.cotox.2017.10.012)
Karagün E, Yıldız P, Cangür S. Effects of climate and air pollution factors on outpatient visits for Eczema: a time series analysis. Arch Dermatol Res., 1–7, 2020.
Chen Y-J, Ho HJ, Wu C-Y, Juan C-K, Wu C-Y. Infantile infection and antibiotic exposure in association with pediatric psoriasis development: A nationwide nested case-control study. J Am Acad Dermatol. 2021;85:626–35. (PMID: 3332115810.1016/j.jaad.2020.12.014)
Hasunuma H, Ishimaru Y, Yoda Y, Shima M. Decline of ambient air pollution levels due to measures to control automobile emissions and effects on the prevalence of respiratory and allergic disorders among children in Japan. Environ Res. 2014;131:111–8. (PMID: 2472763910.1016/j.envres.2014.03.007)
Ngoc LTN, Park D, Lee Y, Lee Y-C, et al. Systematic review and meta-analysis of human skin diseases due to particulate matter. Int J Environ Res Public Health. 2017;14:1458. (PMID: 29186837575087710.3390/ijerph14121458)
Grželj J, Dolenc MS. The role of xenobiotics in triggering psoriasis. Arch Toxicol., 1–24, 2020.
Seo H-M, Park SK, Kim S, Park JH, Oh SU, Kim JS. The comorbidities of Psoriasis and the effects of long-term exposure to air pollution on psoriasis: an urban population-based retrospective cohort study. Research Square.com. Preprint, 2022.
Bertino L, Guarneri F, Cannavò SP, Casciaro M, Pioggia G, Gangemi S. Oxidative stress and atopic dermatitis. Antioxidants. 2020;9:196. (PMID: 32111015713992910.3390/antiox9030196)
Rachakonda TD, Schupp CW, Armstrong AW. Psoriasis prevalence among adults in the United States. J Am Acad Dermatol. 2014;70:512–6. (PMID: 2438872410.1016/j.jaad.2013.11.013)
Kaufman BP, Alexis AF. Psoriasis in skin of color: insights into the epidemiology, clinical presentation, genetics, quality-of-life impact, and treatment of psoriasis in non-white racial/ethnic groups. Am J Clin Dermatol. 2018;19:405–23. (PMID: 2920994510.1007/s40257-017-0332-7)
Lewis-Jones S. Quality of life and childhood atopic dermatitis: the misery of living with childhood Eczema. Int J Clin Pract. 2006;60:984–92. (PMID: 1689344010.1111/j.1742-1241.2006.01047.x)
Cohen JN, Bowman S, Laszik ZG, North JP. Clinicopathologic overlap of Psoriasis, Eczema, and Psoriasiform dermatoses: A retrospective study of t helper type 2 and 17 subsets, interleukin 36, and β-defensin 2 in spongiotic psoriasiform dermatitis, sebopsoriasis, and tumor necrosis factor α inhibitor-associated dermatitis. J Am Acad Dermatol. 2020;82:430–9. (PMID: 3185904710.1016/j.jaad.2019.08.023)
Kim KE, Cho D, Park HJ. Air pollution and skin diseases: Adverse effects of airborne particulate matter on various skin diseases. Life Sci. 2016;152:126–34. (PMID: 2701806710.1016/j.lfs.2016.03.039)
Zhao C-N, Xu Z, Wu G-C, Mao Y-M, Liu L-N, Dan Y-L, et al. Emerging role of air pollution in autoimmune diseases. Autoimmun Rev. 2019;18:607–14. (PMID: 3095921710.1016/j.autrev.2018.12.010)
Keil AP, Buckley JP, O’Brien KM, Ferguson KK, Zhao S, White AJ. A quantile-based g-computation approach to addressing the effects of exposure mixtures. Environ Health Perspect. 2020;128:047004. (PMID: 32255670722810010.1289/EHP5838)
Centers for Disease Control, U.S. Department of Health Prevention (CDC). National Center for Health Statistics (NCHS), and Human Services. National health and nutrition examination survey questionnaire (or examination protocol, or laboratory protocol).
US Census Bureau, Data and Maps, 2022.
Kim S-Y, Bechle M, Hankey S, Sheppard L, Szpiro AA, Marshall JD. Concentrations of criteria pollutants in the contiguous us, 1979–2015: Role of prediction model parsimony in integrated empirical geographic regression. PloS One. 2020;15:e0228535. (PMID: 32069301702828010.1371/journal.pone.0228535)
Pebesma EJ. Simple features for r: standardized support for spatial vector data. R J. 2018;10:439. (PMID: 10.32614/RJ-2018-009)
Van Donkelaar A, Martin RV, Li C, Burnett RT. Regional estimates of chemical composition of fine particulate matter using a combined geoscience-statistical method with information from satellites, models, and monitors. Environ Sci Technol. 2019;53:2595–611. (PMID: 3069800110.1021/acs.est.8b06392)
Hijmans RJ, van Etten J, Mattiuzzi M, Sumner M, Greenberg JA, Lamigueiro OP, et al. Raster package in r, 2013.
Pankow JF, Luo W, Bender DA, Isabelle LM, Hollingsworth JS, Chen C, et al. Concentrations and co-occurrence correlations of 88 volatile organic compounds (VOCs) in the ambient air of 13 semi-rural to urban locations in the United States. Atmos Environ. 2003;37:5023–46. (PMID: 10.1016/j.atmosenv.2003.08.006)
Miller L, Lemke LD, Xu X, Molaroni SM, You H, Wheeler AJ, et al. Intra-urban correlation and spatial variability of air toxics across an international airshed in Detroit, Michigan (USA) and Windsor, Ontario (Canada). Atmos Environ. 2010;44:1162–74. (PMID: 10.1016/j.atmosenv.2009.12.030)
Messier KP, Akita Y, Serre ML. Integrating address geocoding, land use regression, and spatiotemporal geostatistical estimation for groundwater tetrachloroethylene. Environ Sci Technol. 2012;46:2772–80. (PMID: 22264162349428010.1021/es203152a)
Wendee, Nicole. CAFOS and environmental justice: The case of North Carolina. Environ Health Perspect. 2013;121–a182.
Hernán MA, Robins JM. Causal inference. Boca Raton: Chapman & Hall/CRC; 2018.
Textor J, van der Zander B, Gilthorpe MS, Liśkiewicz M, Ellison GTH. Robust causal inference using directed acyclic graphs: the r package ‘dagitty’. Int J Epidemiol. 2016;45:1887–94. (PMID: 28089956)
Glasmeier AK. Living wage calculator. Massachusetts Institute of Technology. livingwage.mit.edu. 2020.
Attwa E, Swelam E. Relationship between smoking-induced oxidative stress and the clinical severity of Psoriasis. J Eur Acad Dermatol Venereol. 2011;25:782–7. (PMID: 2103991510.1111/j.1468-3083.2010.03860.x)
Snowden JM, Rose S, Mortimer KM. Implementation of gcomputation on a simulated data set: demonstration of a causal inference technique. Am J Epidemiol. 2011;173:731–8. (PMID: 21415029310528410.1093/aje/kwq472)
Keil A. Package qgcomp. 2020.
Wild CP. Complementing the genome with an “exposome”: the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Prev Biomark. 2005;14:1847–50. (PMID: 10.1158/1055-9965.EPI-05-0456)
Dominici F, Peng RD, Barr CD, Bell ML. Protecting human health from air pollution: shifting from a single-pollutant to a multi-pollutant approach. Epidemiology. 2010;21:187. (PMID: 20160561347807210.1097/EDE.0b013e3181cc86e8)
Fang T, Guo H, Zeng L, Verma V, Nenes A, Weber RJ. Highly acidic ambient particles, soluble metals, and oxidative potential: a link between sulfate and aerosol toxicity. Environ Sci Technol. 2017;51:2611–20. (PMID: 2814192810.1021/acs.est.6b06151)
Steenhof M, Gosens I, Strak M, Godri KJ, Hoek G, Cassee FR, et al. In vitro toxicity of particulate matter (PM) collected at different sites in the Netherlands is associated with pm composition, size fraction and oxidative potential-the Raptes project. Part Fibre Toxicol. 2011;8:1–15. (PMID: 10.1186/1743-8977-8-26)
Andersen YMF, Egeberg A, Gislason GH, Skov L, Thyssen JP. Autoimmune diseases in adults with atopic dermatitis. J Am Acad Dermatol. 2017;76:274–80. (PMID: 2774217110.1016/j.jaad.2016.08.047)
Allen TEH, Goodman JM, Gutsell S, Russell PJ. Defining molecular initiating events in the adverse outcome pathway framework for risk assessment. Chem Res Toxicol. 2014;27:2100–12. (PMID: 2535431110.1021/tx500345j)
Moroni L, Bianchi I, Lleo A. Geoepidemiology, gender, and autoimmune disease. Autoimmun Rev. 2012;11:A386–A392. (PMID: 2214254710.1016/j.autrev.2011.11.012)
Ortona E, Margutti P, Matarrese P, Franconi F, Malorni W. Redox state, cell death, and autoimmune diseases: a gender perspective. Autoimmun Rev. 2008;7:579–84. (PMID: 1859938410.1016/j.autrev.2008.06.001)
Cobley LAE, Pataki DE, Adler FR, Hinners SJ. Using traffic density and foliar chemistry variables to understand interactions between air pollution and household income. J Geophys Res: Atmos. 2021;126:e2021JD034942. (PMID: 10.1029/2021JD034942)
Szyszkowicz M, Kousha T, Valacchi G. Ambient air pollution and emergency department visits for skin conditions. Glob Dermatol. 2016;3:323–9. (PMID: 10.15761/GOD.1000184)
Song S, Paek D, Park C, Lee C, Lee J-H, Yu S-D. Exposure to ambient ultrafine particles and urinary 8-hydroxyl-2deoxyguanosine in children with and without eczema. Sci Total Environ. 2013;458:408–13. (PMID: 2368536510.1016/j.scitotenv.2013.04.011)
Gawda A, Majka G, Nowak B, Marcinkiewicz J. Air pollution, oxidative stress, and exacerbation of autoimmune diseases. Cent-Eur J Immunol. 2017;42:305. (PMID: 29204097570821310.5114/ceji.2017.70975)
Gangwar RS, Bevan GH, Palanivel R, Das L, Rajagopalan S. Oxidative stress pathways of air pollution mediated toxicity: Recent insights. Redox Biol. 2020;34:101545. (PMID: 32505541732796510.1016/j.redox.2020.101545)
Wang G, Pierangeli SS, Papalardo E, Ansari GAS, Khan MF. Markers of oxidative and nitrosative stress in systemic lupus erythematosus: correlation with disease activity. Arthritis Rheum. 2010;62:2064–72. (PMID: 202010762935652)
Cheng Z, Liang X, Liang S, Yin N, Faiola F. A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis. J Environ Sci. 2020;87:194–204. (PMID: 10.1016/j.jes.2019.06.016)
Gani S, Chambliss SE, Messier KP, Lunden MM, Apte JS. Spatiotemporal profiles of ultrafine particles differ from other traffic-related air pollutants: lessons from long-term measurements at fixed sites and mobile monitoring. Environ Sci: Atmos. 2021;1:558–68.
Lecas S, Boursier E, Fitoussi R, Vi´e K, Momas I, Seta N, et al. In vitro model adapted to the study of skin-ageing induced by air pollution. Toxicol Lett. 2016;259:60–68. (PMID: 2748027910.1016/j.toxlet.2016.07.026)
Kim HO, Kim JH, Cho SI, Chung BY, Ahn IS, Lee CH, et al. Improvement of atopic dermatitis severity after reducing indoor air pollutants. Ann Dermatol. 2013;25:292–7. (PMID: 24003270375619210.5021/ad.2013.25.3.292)
Gallant MJ, Ellis AK. Prenatal and early-life exposure to indoor air polluting factors and allergic sensitization at 2 years of age. Ann Allergy, Asthma Immunol. 2020;124:283–7. (PMID: 3176581410.1016/j.anai.2019.11.019)
Feng J, Chan E, Vet R. Air quality in the Eastern United States and Eastern Canada for 1990–2015: 25 years of change in response to emission reductions of SO 2 and NOx in the region. Atmos Chem Phys. 2020;20:3107–34. (PMID: 10.5194/acp-20-3107-2020)
Marshall JD, Apte JS, Coggins JS, Goodkind AL. Blue skies bluer? Environ Sci Technol. 2015;49:13929–36. (PMID: 2653580910.1021/acs.est.5b03154)
فهرسة مساهمة: Keywords: Air pollution; Criteria pollutants; Dermal exposure; Epidemiology; Geospatial analyses
المشرفين على المادة: 0 (Air Pollutants)
0 (Particulate Matter)
تواريخ الأحداث: Date Created: 20221202 Date Completed: 20230605 Latest Revision: 20230918
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10234803
DOI: 10.1038/s41370-022-00502-0
PMID: 36460922
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-064X
DOI:10.1038/s41370-022-00502-0