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Cerebrospinal fluid irisin and lipoxin A4 are reduced in elderly Brazilian individuals with depression: Insight into shared mechanisms between depression and dementia.

التفاصيل البيبلوغرافية
العنوان: Cerebrospinal fluid irisin and lipoxin A4 are reduced in elderly Brazilian individuals with depression: Insight into shared mechanisms between depression and dementia.
المؤلفون: Gonçalves RA; Centre for Neuroscience Studies, Department of Biomedical and Molecular Sciences & Department of Psychiatry, Queen's University, Kingston, Ontario, Canada., Sudo FK; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Rio de Janeiro, Brazil., Lourenco MV; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Drummond C; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Rio de Janeiro, Brazil., Assunção N; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Rio de Janeiro, Brazil., Vanderborght B; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Rio de Janeiro, Brazil., Ferreira DDP; Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Ribeiro FC; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Pamplona FA; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Rio de Janeiro, Brazil.; Laboratory of Immunopharmacology, Oswald Cruz Institute, Oswald Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.; Biosciences Program, Federal University for Latin American Integration, Foz do Iguaçu, Brazil., Tovar-Moll F; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Rio de Janeiro, Brazil.; Program in Morphological Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Mattos P; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Rio de Janeiro, Brazil.; Program in Morphological Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Ferreira ST; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Rio de Janeiro, Brazil.; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., De Felice FG; Centre for Neuroscience Studies, Department of Biomedical and Molecular Sciences & Department of Psychiatry, Queen's University, Kingston, Ontario, Canada.; D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Rio de Janeiro, Brazil.; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
المصدر: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Jun; Vol. 19 (6), pp. 2595-2604. Date of Electronic Publication: 2022 Dec 09.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
أسماء مطبوعة: Publication: 2020- : Hoboken, NJ : John Wiley & Sons, Ltd.
Original Publication: Orlando, FL : Elsevier, Inc.
مواضيع طبية MeSH: Lipoxins* , Alzheimer Disease*, Animals ; Depression/psychology ; Brain-Derived Neurotrophic Factor ; Fibronectins ; Brazil
مستخلص: Introduction: Depression is frequent among older adults and is a risk factor for dementia. Identifying molecular links between depression and dementia is necessary to shed light on shared disease mechanisms. Reduced brain-derived neurotrophic factor (BDNF) and neuroinflammation are implicated in the pathophysiology of depression and dementia. The exercise-induced hormone, irisin, increases BDNF and improves cognition in animal models of Alzheimer's disease. Lipoxin A4 is a lipid mediator with anti-inflammatory activity. However, the roles of irisin and lipoxin A4 in depression remain to be determined.
Methods: In the present study, blood and CSF were collected from 61 elderly subjects, including individuals with and without cognitive impairment. Screening for symptoms of depression was performed using the 15-item Geriatric Depression Scale (GDS-15).
Results: CSF irisin and lipoxin A4 were positively correlated and reduced, along with a trend of BDNF reduction, in elderly individuals with depression, similar to previous observations in patients with dementia.
Discussion: Our findings provide novel insight into shared molecular signatures connecting depression and dementia.
(© 2022 the Alzheimer's Association.)
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معلومات مُعتمدة: Canada CIHR
فهرسة مساهمة: Keywords: BNDF; dementia; depression; irisin; lipoxin A4; neuroinflammation
المشرفين على المادة: 0 (lipoxin A4)
0 (Brain-Derived Neurotrophic Factor)
0 (Fibronectins)
0 (Lipoxins)
تواريخ الأحداث: Date Created: 20221205 Date Completed: 20230613 Latest Revision: 20230627
رمز التحديث: 20230628
DOI: 10.1002/alz.12893
PMID: 36465055
قاعدة البيانات: MEDLINE
الوصف
تدمد:1552-5279
DOI:10.1002/alz.12893