دورية أكاديمية
أعرض في EDS

Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility.

التفاصيل البيبلوغرافية
العنوان: Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility.
المؤلفون: Woodhouse RM; The University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.; Division of Genome Science and Cancer, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia., Frolows N; The University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.; CSIRO Health and Biosecurity, Sydney, NSW 2113, Australia., Wang G; Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA., Hawdon A; The University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia., Wong EHK; The University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia., Dansereau LC; Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.; St Vincent's Clinical School, UNSW Medicine, University of NSW, Sydney, NSW 2010, Australia., Su Y; Sydney Microscopy and Microanalysis, The University of Sydney, Sydney, NSW 2006, Australia., Adair LD; The University of Sydney, School of Chemistry, Sydney, NSW 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, NSW 2006, Australia., New EJ; The University of Sydney, School of Chemistry, Sydney, NSW 2006, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, NSW 2006, Australia., Philp AM; St Vincent's Clinical School, UNSW Medicine, University of NSW, Sydney, NSW 2010, Australia., Tan WK; The University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia., Philp A; Centre for Healthy Ageing, Centenary Institute, Missenden Road, Sydney, NSW 2050, Australia.; Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, NSW 2006, Australia., Ashe A; The University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
المصدر: IScience [iScience] 2022 Nov 14; Vol. 25 (12), pp. 105573. Date of Electronic Publication: 2022 Nov 14 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: Mitochondrial health is crucial to sperm quality and male fertility, but the precise role of mitochondria in sperm function remains unclear. SDHA is a component of the succinate dehydrogenase (SDH) complex and plays a critical role in mitochondria. In humans, SDH activity is positively correlated with sperm quality, and mutations in SDHA are associated with Leigh Syndrome. Here we report that the C. elegans SDHA orthologue SDHA-2 is essential for male fertility: sdha-2 mutants produce dramatically fewer offspring due to defective sperm activation and motility, have hyperfused sperm mitochondria, and disrupted redox balance. Similar sperm motility defects in sdha-1 and icl-1 mutant animals suggest an imbalance in metabolites may underlie the fertility defect. Our results demonstrate a role for SDHA-2 in sperm motility and male reproductive health and establish an animal model of SDH deficiency-associated infertility.
Competing Interests: The authors declare no competing interests.
(© 2022 The Authors.)
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معلومات مُعتمدة: P40 OD010440 United States OD NIH HHS
فهرسة مساهمة: Keywords: Biological sciences; biochemistry; cell biology; molecular biology
تواريخ الأحداث: Date Created: 20221205 Latest Revision: 20230618
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9709242
DOI: 10.1016/j.isci.2022.105573
PMID: 36465130
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2022.105573