دورية أكاديمية
أعرض في EDS

The Impact of Leukemia on the Detection of Short Tandem Repeat (STR) Markers.

التفاصيل البيبلوغرافية
العنوان: The Impact of Leukemia on the Detection of Short Tandem Repeat (STR) Markers.
المؤلفون: Alharbi SF; Biotechnology, Taif University, Taif, SAU., Alamri A; Pediatric Oncology, King Salman Medical City, Medina, SAU., Elshehawi A; Biotechnology, Taif University, Taif, SAU.
المصدر: Cureus [Cureus] 2022 Nov 01; Vol. 14 (11), pp. e30954. Date of Electronic Publication: 2022 Nov 01 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Introduction: Short tandem repeats (STRs) have been used for various identity typing methods worldwide. They have high discrimination power in human identification in forensics, paternity testing, missed personal identification, genetic diseases, and gene regulatory functions. They have also been used to detect and monitor the stability of diseases, including various types of cancer. This study aimed to investigate the impact of leukemia on the detection and stability of STR markers.
Methods: DNA was isolated from 30 participants (15 with chronic myeloid leukemia( CML) and 15 healthy controls) and used to amplify STR markers using specific primers.
Results: We found that the blood of those with leukemia had more 9.3 and 9 alleles at the tyrosine hydroxylase 1 (TH01) marker than the blood of the healthy control samples. The results of this study will help researchers understand leukemia's effect on the detection and stability of STR markers in leukemic patients compared to healthy individuals.
Conclusion: Our results demonstrate that STR markers could become useful in genetic studies of leukemia cases.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2022, Alharbi et al.)
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فهرسة مساهمة: Keywords: dna typing; forensic dna analysis; leukemia; str markers; th01 marker
تواريخ الأحداث: Date Created: 20221205 Latest Revision: 20221206
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9711926
DOI: 10.7759/cureus.30954
PMID: 36465210
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.30954