دورية أكاديمية
The Impact of Leukemia on the Detection of Short Tandem Repeat (STR) Markers.
العنوان: | The Impact of Leukemia on the Detection of Short Tandem Repeat (STR) Markers. |
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المؤلفون: | Alharbi SF; Biotechnology, Taif University, Taif, SAU., Alamri A; Pediatric Oncology, King Salman Medical City, Medina, SAU., Elshehawi A; Biotechnology, Taif University, Taif, SAU. |
المصدر: | Cureus [Cureus] 2022 Nov 01; Vol. 14 (11), pp. e30954. Date of Electronic Publication: 2022 Nov 01 (Print Publication: 2022). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Palo Alto, CA : Cureus, Inc. |
مستخلص: | Introduction: Short tandem repeats (STRs) have been used for various identity typing methods worldwide. They have high discrimination power in human identification in forensics, paternity testing, missed personal identification, genetic diseases, and gene regulatory functions. They have also been used to detect and monitor the stability of diseases, including various types of cancer. This study aimed to investigate the impact of leukemia on the detection and stability of STR markers. Methods: DNA was isolated from 30 participants (15 with chronic myeloid leukemia( CML) and 15 healthy controls) and used to amplify STR markers using specific primers. Results: We found that the blood of those with leukemia had more 9.3 and 9 alleles at the tyrosine hydroxylase 1 (TH01) marker than the blood of the healthy control samples. The results of this study will help researchers understand leukemia's effect on the detection and stability of STR markers in leukemic patients compared to healthy individuals. Conclusion: Our results demonstrate that STR markers could become useful in genetic studies of leukemia cases. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Alharbi et al.) |
References: | Gene. 2018 Oct 5;673:107-111. (PMID: 29913241) Leg Med (Tokyo). 2014 Jul;16(4):238-40. (PMID: 24767967) Forensic Sci Int. 2005 Jan 6;147(1):101-6. (PMID: 15541599) PLoS One. 2013;8(2):e54710. (PMID: 23405090) Chromosome Res. 2015 Sep;23(3):415-20. (PMID: 26514350) Forensic Sci Int Genet. 2020 Nov;49:102364. (PMID: 32805606) Forensic Sci Rev. 2012 Jan;24(1):15-26. (PMID: 26231356) Ann Hum Biol. 2012 Jan;39(1):80-3. (PMID: 22039975) Genome Res. 1996 Jul;6(7):646-49. (PMID: 8796353) Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012 Jun;29(3):306-8. (PMID: 22678796) Int J Legal Med. 2020 Sep;134(5):1671-1673. (PMID: 32211959) Forensic Sci Int Genet. 2015 Jan;14:e1-3. (PMID: 25270185) Ann Hum Biol. 2020 May;47(3):273-283. (PMID: 32299246) Forensic Sci Int Genet. 2018 Mar;33:98-105. (PMID: 29220824) Nat Rev Neurol. 2015 Oct;11(10):567-84. (PMID: 26392380) Biochem Genet. 1999 Dec;37(11-12):323-34. (PMID: 10690428) Clin Chim Acta. 2012 Feb 18;413(3-4):516-9. (PMID: 22138486) Front Genet. 2020 Aug 06;11:884. (PMID: 32849844) J Med Life. 2015;8(Spec Iss 4):180-185. (PMID: 28316728) J Pediatr. 2008 Aug;153(2):190-3. (PMID: 18534229) Forensic Sci Int Genet. 2013 Jan;7(1):16-21. (PMID: 22658886) J Forensic Sci. 2002 May;47(3):682-5. (PMID: 12051366) Forensic Sci Int Genet. 2008 Jun;2(3):e37-9. (PMID: 19083813) Clin Lab. 2018 Sep 1;64(9):1535-1543. (PMID: 30274026) J Forensic Sci. 2011 Mar;56(2):415-7. (PMID: 21265843) Forensic Sci Int Genet. 2019 Nov;43:102164. (PMID: 31585345) Forensic Sci Int Genet. 2008 Jan;2(1):41-6. (PMID: 19083788) BMC Cancer. 2019 Jul 17;19(1):703. (PMID: 31315607) Mol Genet Genomic Med. 2020 Apr;8(4):e1164. (PMID: 32043756) J Forensic Sci. 2004 Nov;49(6):1265-77. (PMID: 15568700) Forensic Sci Int Genet. 2015 Sep;18:90-9. (PMID: 25937291) Gene. 2014 Apr 25;540(1):32-6. (PMID: 24582974) Int J Legal Med. 1994;106(6):302-11. (PMID: 7947337) Ann Hum Biol. 2020 Feb;47(1):70-75. (PMID: 31984802) Leg Med (Tokyo). 2009 Jan;11(1):45-7. (PMID: 18789747) Forensic Sci Int Genet. 2013 Jul;7(4):e108-13. (PMID: 23706907) Ann Hum Biol. 2020 Aug;47(5):483-489. (PMID: 32543887) Int J Legal Med. 2018 Jul;132(4):1097-1102. (PMID: 29313099) Sci Rep. 2019 May 15;9(1):7452. (PMID: 31092881) Int J Legal Med. 2000;114(1-2):61-5. (PMID: 11197631) Am J Med Genet B Neuropsychiatr Genet. 2008 Jun 5;147B(4):495-9. (PMID: 18085551) Am J Surg. 2007 Sep;194(3):380-4. (PMID: 17693286) Leg Med (Tokyo). 2018 Jan;30:38-41. (PMID: 29154002) Hypertension. 1998 Oct;32(4):676-82. (PMID: 9774362) Mol Cytogenet. 2014 Jan 21;7(Suppl 1 Proceedings of the International Conference on Human):I58. (PMID: 24955126) Int J Legal Med. 2016 Jul;130(4):953-957. (PMID: 27166704) J Forensic Sci. 2006 Mar;51(2):253-65. (PMID: 16566758) Forensic Sci Int Genet. 2019 Mar;39:97-102. (PMID: 30611827) Forensic Sci Int. 2006 May 10;158(2-3):244-9. (PMID: 16143479) Forensic Sci Int Genet. 2019 Jan;38:121-129. (PMID: 30396008) BMC Res Notes. 2021 Feb 23;14(1):69. (PMID: 33622409) J Cancer. 2021 Jan 1;12(2):371-378. (PMID: 33391433) Forensic Sci Int Genet. 2017 Nov;31:34-39. (PMID: 28826062) Forensic Sci Int. 1999 Oct 11;104(2-3):143-6. (PMID: 10581720) Leg Med (Tokyo). 2010 Nov;12(6):324-6. (PMID: 20863737) Gene. 2020 Aug 30;753:144804. (PMID: 32445920) Eur J Hum Genet. 2011 Aug;19(8):924-7. (PMID: 21407269) Forensic Sci Int. 2003 Sep 9;136(1-3):99-101. (PMID: 12969630) Pharmacol Rev. 2004 Sep;56(3):331-49. (PMID: 15317907) Gene. 2014 Sep 15;548(2):217-22. (PMID: 25034657) Mol Biol Rep. 2014 Jun;41(6):3961-72. (PMID: 24562624) Nature. 2001 Feb 15;409(6822):860-921. (PMID: 11237011) Fa Yi Xue Za Zhi. 2012 Jun;28(3):190-4. (PMID: 22812220) Genome Biol. 2018 Aug 21;19(1):121. (PMID: 30129428) Forensic Sci Int Genet. 2021 May;52:102490. (PMID: 33689955) Sci Rep. 2018 Apr 12;8(1):5895. (PMID: 29651125) Hum Hered. 1998 May-Jun;48(3):126-37. (PMID: 9618060) Int J Legal Med. 2020 Sep;134(5):1553-1561. (PMID: 32248307) Biomed Res Int. 2014;2014:697689. (PMID: 25250329) Sci Rep. 2016 Dec 02;6:38225. (PMID: 27910883) Forensic Sci Int Genet. 2017 Nov;31:e59-e61. (PMID: 29030116) Investig Genet. 2015 Jun 30;6:9. (PMID: 26137211) Life Sci. 1997;61(14):1341-7. (PMID: 9335223) Genetika. 2016 Jan;52(1):90-6. (PMID: 27183797) Turk J Med Sci. 2019 Mar 14;49(2):453-457. (PMID: 30866607) Int J Legal Med. 2019 Jul;133(4):1037-1038. (PMID: 30327922) Int J Legal Med. 2015 Sep;129(5):995-6. (PMID: 25821201) |
فهرسة مساهمة: | Keywords: dna typing; forensic dna analysis; leukemia; str markers; th01 marker |
تواريخ الأحداث: | Date Created: 20221205 Latest Revision: 20221206 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9711926 |
DOI: | 10.7759/cureus.30954 |
PMID: | 36465210 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2168-8184 |
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DOI: | 10.7759/cureus.30954 |