دورية أكاديمية
Multiclonal human origin and global expansion of an endemic bacterial pathogen of livestock.
| العنوان: | Multiclonal human origin and global expansion of an endemic bacterial pathogen of livestock. |
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| المؤلفون: | Yebra G; The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom., Harling-Lee JD; The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom., Lycett S; The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom., Aarestrup FM; The National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark., Larsen G; The National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark., Cavaco LM; Department for Bacteria, Parasites and Fungi, Reference Laboratory for Antimicrobial Resistance, Statens Serum Institut, 2300 Copenhagen, Denmark., Seo KS; Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, MS 39762., Abraham S; College of Science Health, Engineering and Education, Antimicrobial Resistance and Infectious Diseases Laboratory, Murdoch University, Murdoch, WA 6150, Australia., Norris JM; Sydney School of Veterinary Science, University of Sydney, Sydney, NSW 2050, Australia., Schmidt T; Department of Medical Microbiology, University of Pretoria, Pretoria 0084, South Africa., Ehlers MM; Department of Medical Microbiology, University of Pretoria, Pretoria 0084, South Africa.; Department of Medical Microbiology, Tshwane Academic Division, National Health Laboratory Service, Pretoria 0084, South Africa., Sordelli DO; Instituto de Investigaciones en Microbiología y Parasitología Médica, University of Buenos Aires-CONICET, C1121 ABG Buenos Aires, Argentina., Buzzola FR; Instituto de Investigaciones en Microbiología y Parasitología Médica, University of Buenos Aires-CONICET, C1121 ABG Buenos Aires, Argentina., Gebreyes WA; Molecular Epidemiology, College of Veterinary Medicine, Ohio State University, Columbus, OH 43210.; Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824., Gonçalves JL; Department of Nutrition and Animal Production, School of Veterinary Medicine and Animal Sciences, University of São Paulo, Pirassununga, SP, 13635-900, Brazil., Dos Santos MV; Department of Nutrition and Animal Production, School of Veterinary Medicine and Animal Sciences, University of São Paulo, Pirassununga, SP, 13635-900, Brazil., Zakaria Z; Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia., Rall VLM; Department of Microbiology and Immunology, Institute of Biosciences, São Paulo State University, Botucatu, SP, 18618-970, Brazil., Keane OM; Animal & Bioscience Department, Teagasc, Grange, Dunsany, Co. Meath C15 PW93, Ireland., Niedziela DA; Animal & Bioscience Department, Teagasc, Grange, Dunsany, Co. Meath C15 PW93, Ireland., Paterson GK; The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom.; The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom., Holmes MA; Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom., Freeman TC; The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom.; Janssen Immunology, Spring House, PA 19002., Fitzgerald JR; The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Dec 13; Vol. 119 (50), pp. e2211217119. Date of Electronic Publication: 2022 Dec 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Staphylococcus aureus*/genetics , Staphylococcal Infections*/epidemiology , Staphylococcal Infections*/veterinary , Staphylococcal Infections*/genetics, Female ; Humans ; Cattle ; Animals ; Livestock/genetics ; Genome ; Host Specificity |
| مستخلص: | Most new pathogens of humans and animals arise via switching events from distinct host species. However, our understanding of the evolutionary and ecological drivers of successful host adaptation, expansion, and dissemination are limited. Staphylococcus aureus is a major bacterial pathogen of humans and a leading cause of mastitis in dairy cows worldwide. Here we trace the evolutionary history of bovine S. aureus using a global dataset of 10,254 S. aureus genomes including 1,896 bovine isolates from 32 countries in 6 continents. We identified 7 major contemporary endemic clones of S. aureus causing bovine mastitis around the world and traced them back to 4 independent host-jump events from humans that occurred up to 2,500 y ago. Individual clones emerged and underwent clonal expansion from the mid-19th to late 20th century coinciding with the commercialization and industrialization of dairy farming, and older lineages have become globally distributed via established cattle trade links. Importantly, we identified lineage-dependent differences in the frequency of host transmission events between humans and cows in both directions revealing high risk clones threatening veterinary and human health. Finally, pangenome network analysis revealed that some bovine S. aureus lineages contained distinct sets of bovine-associated genes, consistent with multiple trajectories to host adaptation via gene acquisition. Taken together, we have dissected the evolutionary history of a major endemic pathogen of livestock providing a comprehensive temporal, geographic, and gene-level perspective of its remarkable success. |
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| معلومات مُعتمدة: | 201531/Z/16/Z United Kingdom WT_ Wellcome Trust |
| فهرسة مساهمة: | Keywords: Staphylococcus aureus; agriculture; host adaptation; phylodynamics; population genomics |
| تواريخ الأحداث: | Date Created: 20221205 Date Completed: 20221207 Latest Revision: 20230207 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9897428 |
| DOI: | 10.1073/pnas.2211217119 |
| PMID: | 36469788 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
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| DOI: | 10.1073/pnas.2211217119 |