دورية أكاديمية
Proteins in Tumor-Derived Plasma Extracellular Vesicles Indicate Tumor Origin.
| العنوان: | Proteins in Tumor-Derived Plasma Extracellular Vesicles Indicate Tumor Origin. |
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| المؤلفون: | Barlin M; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Erdmann-Gilmore P; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Mudd JL; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Zhang Q; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Seymour RW; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Guo Z; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Miessner JR; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Goedegebuure SP; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Bi Y; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Osorio OA; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Alexander-Brett J; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Li S; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Ma CX; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Fields RC; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Townsend RR; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA., Held JM; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Anesthesiology, Washington University School of Medicine in St Louis, St Louis, Missouri, USA. Electronic address: jheld@wustl.edu. |
| المصدر: | Molecular & cellular proteomics : MCP [Mol Cell Proteomics] 2023 Jan; Vol. 22 (1), pp. 100476. Date of Electronic Publication: 2022 Dec 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 101125647 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-9484 (Electronic) Linking ISSN: 15359476 NLM ISO Abbreviation: Mol Cell Proteomics Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Original Publication: Bethesda, MD : American Society for Biochemistry and Molecular Biology, [2002- |
| مواضيع طبية MeSH: | Extracellular Vesicles*/metabolism , Neoplasms*/metabolism, Humans ; Proteomics ; Cell Communication ; Proteome/metabolism |
| مستخلص: | Cancer-derived extracellular vesicles (EVs) promote tumorigenesis, premetastatic niche formation, and metastasis via their protein cargo. However, the proteins packaged by patient tumors into EVs cannot be determined in vivo because of the presence of EVs derived from other tissues. We therefore developed a cross-species proteomic method to quantify the human tumor-derived proteome of plasma EVs produced by patient-derived xenografts of four cancer types. Proteomic profiling revealed individualized packaging of novel protein cargo, and machine learning accurately classified the type of the underlying tumor. Competing Interests: Conflict of interest Dr. Li has received license fee from Envigo and research funding from Pfizer, Takeda Oncology, and Zenopharm not associated with this article. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.) |
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| معلومات مُعتمدة: | P30 CA091842 United States CA NCI NIH HHS; R01 HL152245 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: ProteoClade; cancer; exosomes; extracellular vesicles; machine learning; patient-derived xenografts; proteomics |
| المشرفين على المادة: | 0 (Proteome) |
| تواريخ الأحداث: | Date Created: 20221205 Date Completed: 20230124 Latest Revision: 20240425 |
| رمز التحديث: | 20240425 |
| مُعرف محوري في PubMed: | PMC9801135 |
| DOI: | 10.1016/j.mcpro.2022.100476 |
| PMID: | 36470535 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1535-9484 |
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| DOI: | 10.1016/j.mcpro.2022.100476 |