دورية أكاديمية
أعرض في EDS

How to treat gastrinomas in patients with multiple endocrine neoplasia type1: surgery or long-term proton pump inhibitors?

التفاصيل البيبلوغرافية
العنوان: How to treat gastrinomas in patients with multiple endocrine neoplasia type1: surgery or long-term proton pump inhibitors?
المؤلفون: Imamura M; Neuroendocrine Tumor Center, Kansai Electric Power Hospital, 2-1-7, Fukushima, Fukushima-Ku, Osaka City, 553-0003, Japan. microg606@theia.ocn.ne.jp.; Department of Surgery, Kyoto University Graduate School of Medicine, 54 Shogoin Kawaharacho, Sakyo-Ku, Kyoto City, 606-8507, Japan. microg606@theia.ocn.ne.jp., Komoto I; Department of Surgery, Kansai Electric Power Hospital, 2-1-7, Fukushima, Fukushima-Ku, Osaka City, Japan., Taki Y; Department of Surgery, Kansai Electric Power Hospital, 2-1-7, Fukushima, Fukushima-Ku, Osaka City, Japan.
المصدر: Surgery today [Surg Today] 2023 Dec; Vol. 53 (12), pp. 1325-1334. Date of Electronic Publication: 2022 Dec 07.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Japan NLM ID: 9204360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1436-2813 (Electronic) Linking ISSN: 09411291 NLM ISO Abbreviation: Surg Today Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Tokyo : Springer International, c1992-
مواضيع طبية MeSH: Gastrinoma*/surgery , Gastrinoma*/pathology , Multiple Endocrine Neoplasia Type 1*/complications , Multiple Endocrine Neoplasia Type 1*/surgery , Multiple Endocrine Neoplasia Type 1*/pathology , Neuroendocrine Tumors*/surgery , Neuroendocrine Tumors*/pathology , Pancreatic Neoplasms*/surgery , Pancreatic Neoplasms*/pathology , Zollinger-Ellison Syndrome*/surgery , Zollinger-Ellison Syndrome*/pathology, Humans ; Multiple Endocrine Neoplasia ; Proton Pump Inhibitors
مستخلص: In patients with multiple endocrine neoplasia type 1 syndrome (MEN 1) and Zollinger-Ellison syndrome (ZES), gastrinomas arise from the duodenum, about 60% are multiple, and about 15% of patients have coexisting pancreatic gastrinomas, which can be localized by the selective arterial secretagogue injection test (SASI test). The guidelines (GLs) by the Japanese Neuroendocrine Tumor Society (JNETS) recommend surgical resection for functioning duodenopancreatic neuroendocrine tumors (NETs), including gastrinomas, in patients with MEN1 (Grade A, 100% agreement among members). Conversely, the GLs of the National Comprehensive Cancer Network (NCCN) in the USA recommend observation and treatment with proton pump inhibitors (PPIs) or exploratory surgery for occult gastrinomas. An international Consensus Statement (ICS) from the European Union (EU) also does not recommend resection of gastrinomas in patients with MEN1, despite some surgeons having reported surgery being curative for gastrinomas in MEN1 patients. In this review, we discuss the serious side effects and tumorigenic effects of the prolonged use of PPIs and the safety and curability of surgery, supported by our results of curative surgery for gastrinomas in 20 patients with MEN1 over 30 years. We conclude that surgery should be the first-line treatment for gastrinomas in MEN1 patients.
(© 2022. The Author(s).)
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فهرسة مساهمة: Keywords: Gastrinomas; MEN1; Pancreas preserving total duodenectomy (PPTD); Proton pump inhibitors (PPIs); Selective arterial secretagogue injection test (SASI test)
المشرفين على المادة: 0 (Proton Pump Inhibitors)
تواريخ الأحداث: Date Created: 20221206 Date Completed: 20231205 Latest Revision: 20231205
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10678812
DOI: 10.1007/s00595-022-02627-z
PMID: 36473964
قاعدة البيانات: MEDLINE
الوصف
تدمد:1436-2813
DOI:10.1007/s00595-022-02627-z