دورية أكاديمية
Antiulcerogenic and healing activity of hecogenin acetate in rodents.
| العنوان: | Antiulcerogenic and healing activity of hecogenin acetate in rodents. |
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| المؤلفون: | Sousa AJC; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., de Sousa Neto BP; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., da Costa DS; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., de Sousa MC; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., de Carvalho CES; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., Quintans-Junior LJ; Federal University of Sergipe, Marechal Rondom Avenue, S/N CEP 49.000-100, São Cristóvão, Sergipe, Brazil., Quintans JSS; Federal University of Sergipe, Marechal Rondom Avenue, S/N CEP 49.000-100, São Cristóvão, Sergipe, Brazil., Neves JA; Federal Institute of Education, Science and Technology of Maranhão, Colares Moreira Avenue, 477 - Jardim Renascença, Codó, Maranhão, Brazil., da Silva FV; State University of Maranhão, Morro Do Alecrim, s/n CEP 65.600-000, Maranhão, Caxias, Brazil., Viana AFSC; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., Nunes PHM; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., de Cássia Meneses Oliveira R; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil. rita.oliveira@ufpi.edu.br. |
| المصدر: | Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2023 Apr; Vol. 396 (4), pp. 759-769. Date of Electronic Publication: 2022 Dec 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer Verlag. |
| مواضيع طبية MeSH: | Anti-Ulcer Agents*/therapeutic use , Anti-Ulcer Agents*/toxicity , Stomach Ulcer*/chemically induced , Stomach Ulcer*/drug therapy , Stomach Ulcer*/pathology, Rats ; Animals ; Gastric Mucosa ; Plant Extracts/pharmacology ; Rodentia ; Rats, Wistar ; Ethanol/pharmacology ; Ischemia/drug therapy |
| مستخلص: | Peptic ulcers are lesions in the gastric and duodenal mucosa generated by an imbalance between protective factors (gastroduodenal mucus secretion, bicarbonate production, adequate blood flow) and harmful factors (excess pepsin or hydrochloric acid). Some drugs used in peptic ulcer therapy are associated with adverse effects. The aim of this study was to evaluate the antiulcerogenic and healing activity of hecogenin acetate (HA) in acute and chronic models of gastric lesions in rodents. The antiulcerogenic activity of HA was evaluated in models of gastric lesions induced by absolute ethanol and in acidified ethanol with HA (5, 10, and 20 mg/kg). For the model of gastric lesions induced by ischemia and reperfusion, rats were pre-treated with HA (5, 10, 20 mg/kg). After that, they were submitted to 30 min of ischemia, followed by 1 h of reperfusion. To evaluate the healing activity was induced gastric ulcer using acetic acid (80%) in rats. After 24 h, they were treated for 7 consecutive days with HA (10 and 20 mg/kg). They were evaluated the possible signs of toxicity, measurement of the lesions, collagen deposition, and histological analysis. HA significantly reduced the area of the lesion in models of gastric lesions induced by absolute and acidified ethanol, ischemia-induced gastric lesions and reperfusion, and regarding healing. In the collagen deposition, the presence and increase of collagen demonstrate the healing effect. The AH has antiulcerogenic and healing potential demonstrated by the decrease in gastric injury and presence of collagen fibers, respectively. (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Collagen; Gastroprotection; Hecogenin; Saponins; Ulcer |
| المشرفين على المادة: | 5K0WKD513R (hecogenin acetate) 0 (Plant Extracts) 0 (Anti-Ulcer Agents) 3K9958V90M (Ethanol) |
| تواريخ الأحداث: | Date Created: 20221206 Date Completed: 20230329 Latest Revision: 20230403 |
| رمز التحديث: | 20230404 |
| DOI: | 10.1007/s00210-022-02341-0 |
| PMID: | 36474020 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-1912 |
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| DOI: | 10.1007/s00210-022-02341-0 |