دورية أكاديمية
Antiulcerogenic and healing activity of hecogenin acetate in rodents.
العنوان: | Antiulcerogenic and healing activity of hecogenin acetate in rodents. |
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المؤلفون: | Sousa AJC; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., de Sousa Neto BP; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., da Costa DS; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., de Sousa MC; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., de Carvalho CES; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., Quintans-Junior LJ; Federal University of Sergipe, Marechal Rondom Avenue, S/N CEP 49.000-100, São Cristóvão, Sergipe, Brazil., Quintans JSS; Federal University of Sergipe, Marechal Rondom Avenue, S/N CEP 49.000-100, São Cristóvão, Sergipe, Brazil., Neves JA; Federal Institute of Education, Science and Technology of Maranhão, Colares Moreira Avenue, 477 - Jardim Renascença, Codó, Maranhão, Brazil., da Silva FV; State University of Maranhão, Morro Do Alecrim, s/n CEP 65.600-000, Maranhão, Caxias, Brazil., Viana AFSC; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., Nunes PHM; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil., de Cássia Meneses Oliveira R; Medicinal Plants Research Center, Federal University of Piauí, Nossa Sra. de Fátima Avenue - Fátima, Teresina, Piauí, CEP 64049-550, Brazil. rita.oliveira@ufpi.edu.br. |
المصدر: | Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2023 Apr; Vol. 396 (4), pp. 759-769. Date of Electronic Publication: 2022 Dec 07. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin, New York, Springer Verlag. |
مواضيع طبية MeSH: | Anti-Ulcer Agents*/therapeutic use , Anti-Ulcer Agents*/toxicity , Stomach Ulcer*/chemically induced , Stomach Ulcer*/drug therapy , Stomach Ulcer*/pathology, Rats ; Animals ; Gastric Mucosa ; Plant Extracts/pharmacology ; Rodentia ; Rats, Wistar ; Ethanol/pharmacology ; Ischemia/drug therapy |
مستخلص: | Peptic ulcers are lesions in the gastric and duodenal mucosa generated by an imbalance between protective factors (gastroduodenal mucus secretion, bicarbonate production, adequate blood flow) and harmful factors (excess pepsin or hydrochloric acid). Some drugs used in peptic ulcer therapy are associated with adverse effects. The aim of this study was to evaluate the antiulcerogenic and healing activity of hecogenin acetate (HA) in acute and chronic models of gastric lesions in rodents. The antiulcerogenic activity of HA was evaluated in models of gastric lesions induced by absolute ethanol and in acidified ethanol with HA (5, 10, and 20 mg/kg). For the model of gastric lesions induced by ischemia and reperfusion, rats were pre-treated with HA (5, 10, 20 mg/kg). After that, they were submitted to 30 min of ischemia, followed by 1 h of reperfusion. To evaluate the healing activity was induced gastric ulcer using acetic acid (80%) in rats. After 24 h, they were treated for 7 consecutive days with HA (10 and 20 mg/kg). They were evaluated the possible signs of toxicity, measurement of the lesions, collagen deposition, and histological analysis. HA significantly reduced the area of the lesion in models of gastric lesions induced by absolute and acidified ethanol, ischemia-induced gastric lesions and reperfusion, and regarding healing. In the collagen deposition, the presence and increase of collagen demonstrate the healing effect. The AH has antiulcerogenic and healing potential demonstrated by the decrease in gastric injury and presence of collagen fibers, respectively. (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
References: | Boeing T et al (2021). Gastric healing effect of p-coumaric acid isolated from Baccharis dracunculifolia DC on animal model. Naunyn-Schmiedeberg's Arch Pharmacol 394: 49-57. https://doi.org/10.1007/s00210-020-01928-9. Campos ACL, Borges-Branco A, Groth AK (2007) Cicatrização de feridas. Arq Bras Cir Dig 20:51–58. https://doi.org/10.1590/S0102-67202007000100010. (PMID: 10.1590/S0102-67202007000100010) Carvalho YMBG et al (2017) Inclusion complex between b-cyclodextrin and hecogenin acetate produces superior analgesic effect in animal models for orofacial pain. Biomed Pharmacother 93:754–762. https://doi.org/10.1016/j.biopha.2017.06.091. (PMID: 10.1016/j.biopha.2017.06.09128704800) Cerqueira GS et al (2012) Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. Eur J Pharmacol 683:260–269. https://doi.org/10.1016/j.ejphar.2012.02.043. (PMID: 10.1016/j.ejphar.2012.02.043) Cerqueira, GS (2012). Efeitos farmacológicos e possíveis mecanismos de ação da hecogenina em modelos animais de lesão gástrica. Thesis (Doctorate in Farmacology) Universidade Federal do Ceará – UFC, Brazil. Cripps AL, Bluden G (1978) A quantitative gas-liquid chromatographic method for the estimation of hecogenin and tigogenin in the leaves, juice and sapogenin concentrates of agave sisalana. Steroids 31:661–669. https://doi.org/10.1016/S0039-128X(78)80006-3. (PMID: 10.1016/S0039-128X(78)80006-3675738) Daemi A et al (2019) Topical administration of hydroethanolic extract of Lawsonia inermis (henna) accelerates excisional wound healing process by reducing tissue inflammation and amplifying glucose uptake. Kaohsiung J Med Sci 35:24–32. https://doi.org/10.1002/kjm2.12005. (PMID: 10.1002/kjm2.1200530844141) Ercan G et al (2019) Potent therapeutic effects of ruscogenin on gastric ulcer established by acetic acid. Asian J Surg 19:1–12. https://doi.org/10.1016/j.asjsur.2019.07.001. (PMID: 10.1016/j.asjsur.2019.07.001) Evora PRB et al (1996) Lesão de Isquemia-Reperfusão. Aspectos Fisiopatológicos e a Importância da Função Endotelial. Arq Bras Cardiol 66:239–245. (PMID: 8935692) Ewald BT et al (2015) Atividade gastroprotetora do extrato etanólico de Pavonia alnifolia A.St.- Hil. Rev Bras Plantas Med 17:392–397. https://doi.org/10.1590/1983-084X/13_054. (PMID: 10.1590/1983-084X/13_054) Fazalda A, Quraisiah A, Azlina MFN (2018) Antiulcer effect of honey in nonsteroidal anti-inflammatory drugs induced gastric ulcer model in rats: a systematic review. Evid Based Complementary Altern Med 2018:1–12. https://doi.org/10.1155/2018/7515692. (PMID: 10.1155/2018/7515692) Farahpour MR et al (2020) Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis. Pharm Biol 59:1–10. https://doi.org/10.1080/13880209.2020.1861029. (PMID: 10.1080/13880209.2020.18610297782911) Gama KB et al (2013) Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. J Nat Prod 76:559–563. https://doi.org/10.1021/np3007342. (PMID: 10.1021/np300734223437926) Ingawale DK, Patel SS (2016) Anti-inflammatory potential of hecogenin in experimental animals: possible involvement of inflammatory cytokines and myeloperoxidase. Drug Res 66:644–656. https://doi.org/10.1055/s-0042-113184. (PMID: 10.1055/s-0042-113184) Kaiser S et al (2010) Estudo da relação estrutura-atividade de saponinas hemolíticas e/ou imunoadjuvantes mediante uso de análise multivariada. Rev Bras Farmacogn 20:300–309. https://doi.org/10.1590/S0102-695X2010000300003. (PMID: 10.1590/S0102-695X2010000300003) Kayser C et al (2006) Tratamento de pacientes com úlceras isquêmicas secundárias à esclerose sistêmica com N-acetilcisteína endovenosa. Rev Bras Reumatol 46:148–152. https://doi.org/10.1590/S0482-50042006000200012. (PMID: 10.1590/S0482-50042006000200012) Kumar A, Ashwlayan V, Verma M (2019). Diagnostic approach & pharmacological treatment regimen of Peptic Ulcer Disease. Phar Pharm Res Open Acc J 1:01–12. https://doi.org/10.30881/pproaj.00001. Kuna L et al (2019) Peptic ulcer disease: a brief review of conventional therapy and herbal treatment options. J Clin Med 8:1–19. https://doi.org/10.3390/jcm8020179. (PMID: 10.3390/jcm8020179) Li Q et al (2018) Activity of Brucea javanica oil emulsion against gastric ulcers in rodents. Asian J Pharm Sci 13:279–288. https://doi.org/10.1016/j.ajps.2017.12.005. (PMID: 10.1016/j.ajps.2017.12.00532104401) Lima CM et al (2014) Valores de referência hematológicos e bioquímicos de ratos (Rattus novergicus linhagem Wistar) provenientes do biotério da Universidade Tiradentes. Scientia Plena 10:1–9. Lu HJ et al (2014) Ruscogenin ameliorates diabetic nephropathy by its anti-inflammatory and antifibrotic effects in streptozotocin-induced diabetic rat. BMC Complement Altern Med 14:1–12. https://doi.org/10.1186/1472-6882-14-110. (PMID: 10.1186/1472-6882-14-110) Malfertheiner P, Schulz C (2020) Peptic ulcer: chapter closed? Dig Dis 38:112–116. https://doi.org/10.1159/000505367. (PMID: 10.1159/000505367) Murdoch D, Mctavish D (1991) Roxatidine acetate a review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic potential in peptic ulcer disease and related disorders. Drugs 42(240):260. https://doi.org/10.2165/00003495-199142020-00006. (PMID: 10.2165/00003495-199142020-00006) Mussy JHA et al (2014). Cicatrização de ferimentos incisionais em ratos submetidos a alimentação com carne suína Rev Par Med 28:9-18. Nehra AK et al (2018) Proton pump inhibitors: review of emerging concerns. Mayo Clin Proc 93:240–246. https://doi.org/10.1016/j.mayocp.2017.10.022. (PMID: 10.1016/j.mayocp.2017.10.02229406201) Périco LL et al (2020) Systematic analysis of monoterpenes: advances and challenges in the treatment of peptic ulcer diseases. Biomolecules 10:1–18. https://doi.org/10.3390/biom10020265. (PMID: 10.3390/biom10020265) Possenti A et al (2011) Atividade antiulcerogênica e mecanismo de ação de alimento fermentado à base de trigo e soja utilizado como alimento funcional. Ged Gastroenterol Endosc Dig 30:125–130. Pundir CS, Kumar P, Jaiwal R (2019) Biosensing methods for determination of creatinine: a review. Biosens Bioelectron 126:707–724. https://doi.org/10.1016/j.bios.2018.11.031. (PMID: 10.1016/j.bios.2018.11.03130551062) Quintans JSS et al (2014) Evidence for the involvement of spinal cord-inhibitory and cytokines modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice. Molecules 19:8303–8316. https://doi.org/10.3390/molecules19068303. (PMID: 10.3390/molecules19068303249504366270830) Ribeiro-Junior JA et al (2015) Gastroprotective effect of geopropolis from melipona scutellarisis dependent on production of nitric oxide and prostaglandin. Evid Based Complementary Altern Med 2015:1–5. (PMID: 10.1155/2015/459846) Rosa RL (2013). Avaliação do potencial gastroprotetor e antiúlcera das sementes da Eugenia involucrata dc. (cereja do mato) e Artocarpus heterophyllus lam. (jaca) em roedores. Dissertation (Master in Pharmaceutical Sciences). Universidade do Vale do Itajaí – UNIVALI, Brazil. Tarasconi A et al. (2021). Perforated and bleeding peptic ulcer: WSES guidelines. World J Emerg Surg 15:1–24. https://doi.org/10.1186/s13017-019-0283-9. Xing M et al (2020) Human-like collagen promotes the healing of acetic acid-induced gastric ulcers in rats by regulating NOS and growth factors. Food Funct 11:4123–4137. https://doi.org/10.1039/D0FO00288G. (PMID: 10.1039/D0FO00288G32347870) Zullo MAT et al (1984) Efeito de diferentes condições de fermentação sobre o teor e composição da fração de sapogeninas do suco de sisal. Bragantia 2:479–486. https://doi.org/10.1590/S0006-87051984000200018. (PMID: 10.1590/S0006-87051984000200018) Zullo MAT et al (1989) Sapogeninas esteroídicas em sisal. Bragantia 48:21–25. https://doi.org/10.1590/S0006-87051989000100003. (PMID: 10.1590/S0006-87051989000100003) |
فهرسة مساهمة: | Keywords: Collagen; Gastroprotection; Hecogenin; Saponins; Ulcer |
المشرفين على المادة: | 5K0WKD513R (hecogenin acetate) 0 (Plant Extracts) 0 (Anti-Ulcer Agents) 3K9958V90M (Ethanol) |
تواريخ الأحداث: | Date Created: 20221206 Date Completed: 20230329 Latest Revision: 20230403 |
رمز التحديث: | 20230404 |
DOI: | 10.1007/s00210-022-02341-0 |
PMID: | 36474020 |
قاعدة البيانات: | MEDLINE |
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