دورية أكاديمية
Use of acellular dermal matrix in peripheral nerve reconstruction: an experimental study on rat sciatic nerve defect.
| العنوان: | Use of acellular dermal matrix in peripheral nerve reconstruction: an experimental study on rat sciatic nerve defect. |
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| المؤلفون: | Ceran F; Department of Plastic, Reconstructive and Aesthetic Surgery, Medicalpark Hospital, Batman, Turkey., Pilanci O; Department of Plastic, Reconstructive and Aesthetic Surgery, Bagcilar Training and Research Hospital, Istanbul, Turkey., Ozel A; Department of Plastic, Reconstructive and Aesthetic Surgery, Bagcilar Training and Research Hospital, Istanbul, Turkey., Ilbay G; Faculty of Medicine, Department of Physiology, Kocaeli University, Kocaeli, Turkey., Karabacak R; Faculty of Medicine, Department of Histology, Medeniyet University, Istanbul, Turkey., Kanter M; Faculty of Medicine, Department of Histology, Medeniyet University, Istanbul, Turkey., Ilbay K; Faculty of Medicine, Department of Neurosurgery, Kocaeli University, Kocaeli, Turkey., Kuvat SV; Department of Plastic, Reconstructive and Aesthetic Surgery, Bagcilar Training and Research Hospital, Istanbul, Turkey. |
| المصدر: | Journal of plastic surgery and hand surgery [J Plast Surg Hand Surg] 2023 Feb-Dec; Vol. 57 (1-6), pp. 445-452. Date of Electronic Publication: 2022 Dec 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medical Journals Sweden AB Country of Publication: Sweden NLM ID: 101534130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2000-6764 (Electronic) Linking ISSN: 20006764 NLM ISO Abbreviation: J Plast Surg Hand Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Uppsala, Sweden : Medical Journals Sweden AB Original Publication: Stockholm : Informa Healthcare, 2010- |
| مواضيع طبية MeSH: | Acellular Dermis* , Plastic Surgery Procedures*, Rats ; Animals ; Rats, Sprague-Dawley ; Sciatic Nerve/surgery ; Sciatic Nerve/physiology ; Wound Healing |
| مستخلص: | Background: In patients with nerve tissue defects, the use of autologous nerve grafts is the standard method of treatment. Alternatives to autologous, nerve grafts have attracted the attention of reconstructive surgeons. In this study, the results of nerve repairs using acellular dermal matrix (ADM) in an experimental rat sciatic nerve defect model are presented. Methods: Thirty-six Sprague-Dawley rats were randomized into 5 groups: Group 1: control group, Group 2: negative control group ( n = 6), Group 3: autologous nerve graft group ( n = 10), Group 4: donor site entubulated with ADM group ( n = 10); and Group 5: nerve graft entubulated with ADM group ( n = 10). The animals in each group were evaluated for electrophysiologic functions, gastrocnemius muscle weight and histomorphology on the 3rd and 6th month. Results: The compound muscle action potential was observed to be distinctly lower in Groups 3, 4 and 5 in comparison to the control group. In Group 4, the gastrocnemius ratio (GCR) values on the 6th month were statistically significantly lower than the GCR values in Group 3 and Group 5, The histological scores and myelinated axonal counts in Group 5 were statistically significantly higher than the values in Group 3 and Group 4. Conclusion: The results of this study showed that wrapping ADM around nerve grafts resulted in better outcomes with respect to nerve healing. |
| فهرسة مساهمة: | Keywords: Acellular dermal matrix; peripheral nerve; reconstruction |
| تواريخ الأحداث: | Date Created: 20221208 Date Completed: 20230301 Latest Revision: 20230301 |
| رمز التحديث: | 20230301 |
| DOI: | 10.1080/2000656X.2022.2152824 |
| PMID: | 36476277 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 2000-6764 |
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| DOI: | 10.1080/2000656X.2022.2152824 |