دورية أكاديمية
أعرض في EDS

In Situ Sprayed Biotherapeutic Gel Containing Stable Microbial Communities for Efficient Anti-Infection Treatment.

التفاصيل البيبلوغرافية
العنوان: In Situ Sprayed Biotherapeutic Gel Containing Stable Microbial Communities for Efficient Anti-Infection Treatment.
المؤلفون: Yan JH; Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China., Zheng DW; Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China., Gu HY; Department of Orthopedic Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P. R. China., Yu YJ; Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China., Zeng JY; Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China., Chen QW; Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China., Yu AX; Department of Orthopedic Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P. R. China., Zhang XZ; Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.; Department of Orthopedic Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P. R. China.
المصدر: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2023 Feb; Vol. 10 (4), pp. e2205480. Date of Electronic Publication: 2022 Dec 07.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim : WILEY-VCH, [2014]-
مواضيع طبية MeSH: Anti-Infective Agents* , Bacterial Infections*/drug therapy, Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteria ; Poloxalene/pharmacology
مستخلص: Systematic administration of antibiotics to treat infections often leads to the rapid evolution and spread of multidrug-resistant bacteria. Here, an in situ-formed biotherapeutic gel that controls multidrug-resistant bacterial infections and accelerates wound healing is reported. This biotherapeutic gel is constructed by incorporating stable microbial communities (kombucha) capable of producing antimicrobial substances and organic acids into thermosensitive Pluronic F127 (polyethylene-polypropylene glycol) solutions. Furthermore, it is found that the stable microbial communities-based biotherapeutic gel possesses a broad antimicrobial spectrum and strong antibacterial effects in diverse pathogenic bacteria-derived xenograft infection models, as well as in patient-derived multidrug-resistant bacterial xenograft infection models. The biotherapeutic gel system considerably outperforms the commercial broad-spectrum antibacterial gel (0.1% polyaminopropyl biguanide) in pathogen removal and infected wound healing. Collectively, this biotherapeutic strategy of exploiting stable symbiotic consortiums to repel pathogens provides a paradigm for developing efficient antibacterial biomaterials and overcomes the failure of antibiotics to treat multidrug-resistant bacterial infections.
(© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.)
References: Food Microbiol. 2022 May;103:103963. (PMID: 35082080)
Adv Sci (Weinh). 2019 Aug 27;6(20):1900513. (PMID: 31637157)
Science. 2015 Apr 3;348(6230):80-6. (PMID: 25838377)
Nat Mater. 2021 May;20(5):691-700. (PMID: 33432140)
Compr Rev Food Sci Food Saf. 2020 Jul;19(4):2050-2070. (PMID: 33337078)
Nat Chem Biol. 2021 Mar;17(3):351-359. (PMID: 33349707)
Med Res Rev. 2018 Sep;38(5):1614-1660. (PMID: 29485730)
Trends Immunol. 2009 Mar;30(3):131-41. (PMID: 19217824)
Theranostics. 2019 Apr 13;9(9):2678-2693. (PMID: 31131061)
Science. 2018 Sep 21;361(6408):. (PMID: 30237322)
Curr Biol. 2020 Oct 5;30(19):R1203-R1214. (PMID: 33022265)
Food Technol Biotechnol. 2014 Dec;52(4):420-429. (PMID: 27904315)
Cell. 2014 Aug 28;158(5):1072-1082. (PMID: 25171408)
Cell Host Microbe. 2022 May 11;30(5):675-683. (PMID: 35550670)
Theranostics. 2018 Nov 10;8(20):5703-5712. (PMID: 30555575)
Immunity. 2019 Aug 20;51(2):272-284.e7. (PMID: 31399282)
Nat Commun. 2021 Apr 16;12(1):2299. (PMID: 33863908)
Curr Pharm Biotechnol. 2019;20(11):985-990. (PMID: 31322066)
Compr Rev Food Sci Food Saf. 2022 Mar;21(2):1024-1053. (PMID: 35075759)
Lancet Infect Dis. 2021 Jul;21(7):e191-e201. (PMID: 33347816)
Sci Adv. 2020 May 15;6(20):eaba4311. (PMID: 32440554)
Sci Adv. 2020 Oct 23;6(43):. (PMID: 33097529)
Nature. 2019 Nov;575(7781):224-228. (PMID: 31666699)
Adv Sci (Weinh). 2023 Feb;10(4):e2205480. (PMID: 36479844)
Science. 1974 Oct 25;186(4161):363-5. (PMID: 4415781)
Science. 2019 Jun 21;364(6446):1179-1184. (PMID: 31221858)
Cell Host Microbe. 2021 Aug 11;29(8):1235-1248.e8. (PMID: 34214492)
Nature. 2016 Jan 21;529(7586):336-43. (PMID: 26791724)
Drugs. 2006;66(9):1253-61. (PMID: 16827601)
Nat Rev Microbiol. 2022 Apr;20(4):189. (PMID: 35091713)
Int J Biol Macromol. 2020 Aug 1;156:1530-1538. (PMID: 31785297)
Nature. 2017 Nov 15;551(7680):313-320. (PMID: 29144467)
Nature. 2016 Aug 4;536(7614):81-85. (PMID: 27437587)
معلومات مُعتمدة: 22135005 National Natural Science Foundation of China; 51833007 National Natural Science Foundation of China; 51988102 National Natural Science Foundation of China; 2019YFA0905603 National Key Research and Development Program of China; Institutional Animal Care and Use Committee (IACUC); HZAUMO-2022-0077 Animal Experiment Center of Huazhong Agricultural University, Wuhan, P. R. China
فهرسة مساهمة: Keywords: anti-infection; gels; kombucha; microbes; multidrug-resistance
المشرفين على المادة: 0 (Anti-Infective Agents)
0 (Anti-Bacterial Agents)
9003-11-6 (Poloxalene)
تواريخ الأحداث: Date Created: 20221208 Date Completed: 20230206 Latest Revision: 20230214
رمز التحديث: 20230214
مُعرف محوري في PubMed: PMC9896078
DOI: 10.1002/advs.202205480
PMID: 36479844
قاعدة البيانات: MEDLINE
الوصف
تدمد:2198-3844
DOI:10.1002/advs.202205480