دورية أكاديمية
أعرض في EDS

Chronobiological parameters as predictors of early treatment response in major depression.

التفاصيل البيبلوغرافية
العنوان: Chronobiological parameters as predictors of early treatment response in major depression.
المؤلفون: Xavier NB; Laboratório de Cronobiologia e Sono, HCPA/UFRGS, Porto Alegre, RS, Brazil; Graduate Program in Psychiatry and Behavioral Sciences, Faculty of Medicine, UFRGS, Porto Alegre, RS, Brazil. Electronic address: nbxavier@hcpa.edu.br., Abreu ACVO; Laboratório de Cronobiologia e Sono, HCPA/UFRGS, Porto Alegre, RS, Brazil., Amando GR; Laboratório de Cronobiologia e Sono, HCPA/UFRGS, Porto Alegre, RS, Brazil; Graduate Program in Psychiatry and Behavioral Sciences, Faculty of Medicine, UFRGS, Porto Alegre, RS, Brazil., Steibel EG; Laboratório de Cronobiologia e Sono, HCPA/UFRGS, Porto Alegre, RS, Brazil., Pilz LK; Laboratório de Cronobiologia e Sono, HCPA/UFRGS, Porto Alegre, RS, Brazil; Graduate Program in Psychiatry and Behavioral Sciences, Faculty of Medicine, UFRGS, Porto Alegre, RS, Brazil., Freitas JJ; Laboratório de Cronobiologia e Sono, HCPA/UFRGS, Porto Alegre, RS, Brazil; Graduate Program in Psychiatry and Behavioral Sciences, Faculty of Medicine, UFRGS, Porto Alegre, RS, Brazil., da Silveira Cruz-Machado S; Department of Physiological Sciences, Institute of Biological Sciences, Federal University of Rio Grande, FURG, Rio Grande, RS, Brazil., Markus RP; Laboratory of Chronopharmacology, Institute Bioscience, University of São Paulo, Brazil., Frey BN; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada; Mood Disorders Program and Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Canada., Hidalgo MP; Laboratório de Cronobiologia e Sono, HCPA/UFRGS, Porto Alegre, RS, Brazil; Graduate Program in Psychiatry and Behavioral Sciences, Faculty of Medicine, UFRGS, Porto Alegre, RS, Brazil. Electronic address: mhidalgo@hcpa.edu.br.
المصدر: Journal of affective disorders [J Affect Disord] 2023 Feb 15; Vol. 323, pp. 679-688. Date of Electronic Publication: 2022 Dec 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Depressive Disorder, Major*/drug therapy, Adult ; Humans ; Female ; Depression ; Circadian Rhythm/physiology ; Sleep/physiology ; Antidepressive Agents/therapeutic use ; Surveys and Questionnaires
مستخلص: Background: Alterations in circadian system organization have been related to major depressive disorder manifestations. This study aimed to evaluate chronobiological parameters, such as sleep, levels of 6-sulfatoxymelatonin, and others derived from actimetry as potential predictors of adequate treatment response in MDD.
Methods: 98 adult women with confirmed diagnosis of MDD were included. Participants completed standard questionnaires (Hamilton Depression Rating Scale - HAM-D; Munich Chronotype Questionnaire - MCTQ) at baseline and after 4 weeks of treatment. Urinary samples for assessing 6-sulfatoxymelatonin were collected on the day before and immediately after pharmacological treatment administration, and 28 continuous days of actigraphy data were collected during the protocol. Participants were classified into Responder (R) or Non-responder (NR) to antidepressant treatment in 4 weeks (early responder), which was characterized by a ≥50 % decrease in the HAM-D score.
Results: The following biological rhythms variables significantly predicted a better treatment response in a model controlling for age, sex, and previous treatments: higher levels of activity (M10 - average activity in the 10 most active hours within the 24 h-day) and an earlier center of the 10 most active hours (M10c), as well as lower intradaily variability (IV) of light exposure. Sleep parameters and 6-sulfatoxymelatonin levels did not associate with treatment response prediction.
Limitation: Actimetry data were not assessed before changing in the treatment plan.
Conclusion: Different patterns in activity and light exposure might be linked to early antidepressant response.
Competing Interests: Conflict of Interest The authors declare no conflict of interest.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: 6-Sulfatoxymelatonin; Actigraphy; Chronomedicine; Circadian rhythms; Major depressive disorder; Mood disorders
المشرفين على المادة: 0 (Antidepressive Agents)
تواريخ الأحداث: Date Created: 20221208 Date Completed: 20230112 Latest Revision: 20230317
رمز التحديث: 20231215
DOI: 10.1016/j.jad.2022.12.002
PMID: 36481230
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-2517
DOI:10.1016/j.jad.2022.12.002