دورية أكاديمية
Statistical analysis of preclinical inter-species concordance of histopathological findings in the eTOX database.
العنوان: | Statistical analysis of preclinical inter-species concordance of histopathological findings in the eTOX database. |
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المؤلفون: | Wright PSR; University of Cambridge, Centre for Molecular Science Informatics, Department of Chemistry, Cambridge, United Kingdom. Electronic address: psrw2@cam.ac.uk., Briggs KA; Lhasa Limited, Leeds, United Kingdom., Thomas R; Lhasa Limited, Leeds, United Kingdom., Smith GF; AstraZeneca, Data Science and AI, Clinical Pharmacology and Safety Sciences, R&D, Cambridge, United Kingdom., Maglennon G; AstraZeneca, Oncology Pathology, Clinical Pharmacology and Safety Sciences, R&D, Melbourn, United Kingdom., Mikulskis P; AstraZeneca, Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences, R&D, Gothenburg, Sweden., Chapman M; AstraZeneca, Toxicology, Clinical Pharmacology and Safety Sciences, R&D, Melbourn, United Kingdom., Greene N; AstraZeneca, Data Science and Artificial Intelligence, Clinical Pharmacology and Safety Sciences, R&D, Boston, MA, USA., Phillips BU; AstraZeneca, Data Sciences and Quantitative Biology, Discovery Sciences, Cambridge Biomedical Campus, Cambridge, United Kingdom., Bender A; University of Cambridge, Centre for Molecular Science Informatics, Department of Chemistry, Cambridge, United Kingdom. Electronic address: andreas.bender@cantab.net. |
المصدر: | Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2023 Feb; Vol. 138, pp. 105308. Date of Electronic Publication: 2022 Dec 05. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214983 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0295 (Electronic) Linking ISSN: 02732300 NLM ISO Abbreviation: Regul Toxicol Pharmacol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2003>- : Amsterdam : Elsevier Original Publication: New York : Academic Press, [c1981- |
مواضيع طبية MeSH: | Drug-Related Side Effects and Adverse Reactions*, Animals ; Female ; Rats ; Dogs ; Databases, Factual ; Research Design |
مستخلص: | Preclinical inter-species concordance can increase the predictivity of observations to the clinic, potentially reducing drug attrition caused by unforeseen adverse events. We quantified inter-species concordance of histopathological findings and target organ toxicities across four preclinical species in the eTOX database using likelihood ratios (LRs). This was done whilst only comparing findings between studies with similar compound exposure (Δ|C Competing Interests: Declaration of competing interest The authors declare the following financial/personal relationships which may be considered as potential competing interests: PW is funded by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs). KB, and RT are employees of Lhasa Limited. GF, GM, PM, MC, NG, and BP are employees of AstraZeneca. AB is a co-founder of Healx Ltd., and PharmEnable Ltd., and is a consultant for various pharmaceutical and consumer goods companies. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.) |
معلومات مُعتمدة: | NC/R001952/1 United Kingdom NC3RS_ National Centre for the Replacement, Refinement and Reduction of Animals in Research |
فهرسة مساهمة: | Keywords: Concordance; Drug development; Histopathology; Preclinical studies; Statistical modeling; Toxicology; Translational |
تواريخ الأحداث: | Date Created: 20221208 Date Completed: 20230208 Latest Revision: 20230215 |
رمز التحديث: | 20231215 |
DOI: | 10.1016/j.yrtph.2022.105308 |
PMID: | 36481279 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1096-0295 |
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DOI: | 10.1016/j.yrtph.2022.105308 |