دورية أكاديمية
أعرض في EDS

Role of supplementary motor area in cervical dystonia and sensory tricks.

التفاصيل البيبلوغرافية
العنوان: Role of supplementary motor area in cervical dystonia and sensory tricks.
المؤلفون: Cho HJ; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. hyunjoo.cho@nih.gov., Waugh R; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Department of Psychology, University of Virginia, Charlottesville, VA, USA., Wu T; Clinical Trial Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Panyakaew P; Department of Medicine, Chulalongkorn Centre of Excellence for Parkinson's Disease and Related Disorders, Faculty of Medicine, Chulalongkorn University and King, Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand., Mente K; Departments of Neurology and Pathology, Case Western Reserve University, Cleveland, USA.; Neurology Service, VA Northeast Ohio Healthcare System, Cleveland, OH, USA.; Cleveland Alzheimer's Disease Research Center, Cleveland, OH, USA., Urbano D; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA., Hallett M; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Horovitz SG; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
المصدر: Scientific reports [Sci Rep] 2022 Dec 08; Vol. 12 (1), pp. 21206. Date of Electronic Publication: 2022 Dec 08.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Torticollis*/diagnostic imaging , Motor Cortex*/diagnostic imaging, Humans
مستخلص: Sensory trick is a characteristic feature of cervical dystonia (CD), where a light touch on the area adjacent to the dystonia temporarily improves symptoms. Clinical benefit from sensory tricks can be observed before tactile contact is made or even by imagination. The supplementary motor area (SMA) may dynamically interact with the sensorimotor network and other brain regions during sensory tricks in patients with CD. In this study, we examined the functional connectivity of the SMA at rest and during sensory trick performance and imagination in CD patients compared to healthy controls using functional magnetic resonance imaging. The functional connectivity between the SMA and left intraparietal sulcus (IPS) region was lower in CD patients at rest and it increased with sensory trick imagination and performance. SMA-right cerebellum connectivity also increased with sensory trick imagination in CD patients, while it decreased in healthy controls. In CD patients, SMA connectivity increased in the brain regions involved in sensorimotor integration during sensory trick performance and imagination. Our study results showed a crucial role of SMA in sensorimotor processing during sensory trick performance and imagination and suggest the IPS as a novel potential therapeutic target for brain modulation.
(© 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
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تواريخ الأحداث: Date Created: 20221209 Date Completed: 20221215 Latest Revision: 20230112
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9731945
DOI: 10.1038/s41598-022-25316-w
PMID: 36481868
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-022-25316-w