دورية أكاديمية
On the quest of reliable 3D dynamic in vitro blood-brain barrier models using polymer hollow fiber membranes: Pitfalls, progress, and future perspectives.
| العنوان: | On the quest of reliable 3D dynamic in vitro blood-brain barrier models using polymer hollow fiber membranes: Pitfalls, progress, and future perspectives. |
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| المؤلفون: | Mantecón-Oria M; Departamento de Ingenierias Química y Biomolecular, Universidad de Cantabria, Santander, Spain.; Instituto Marqués de Valdecilla (IDIVAL), Santander, Spain., Rivero MJ; Departamento de Ingenierias Química y Biomolecular, Universidad de Cantabria, Santander, Spain., Diban N; Departamento de Ingenierias Química y Biomolecular, Universidad de Cantabria, Santander, Spain.; Instituto Marqués de Valdecilla (IDIVAL), Santander, Spain., Urtiaga A; Departamento de Ingenierias Química y Biomolecular, Universidad de Cantabria, Santander, Spain.; Instituto Marqués de Valdecilla (IDIVAL), Santander, Spain. |
| المصدر: | Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2022 Nov 22; Vol. 10, pp. 1056162. Date of Electronic Publication: 2022 Nov 22 (Print Publication: 2022). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101632513 Publication Model: eCollection Cited Medium: Print ISSN: 2296-4185 (Print) Linking ISSN: 22964185 NLM ISO Abbreviation: Front Bioeng Biotechnol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2013]- |
| مستخلص: | With the increasing concern of neurodegenerative diseases, the development of new therapies and effective pharmaceuticals targeted to central nervous system (CNS) illnesses is crucial for ensuring social and economic sustainability in an ageing world. Unfortunately, many promising treatments at the initial stages of the pharmaceutical development process, that is at the in vitro screening stages, do not finally show the expected results at the clinical level due to their inability to cross the human blood-brain barrier (BBB), highlighting the inefficiency of in vitro BBB models to recapitulate the real functionality of the human BBB. In the last decades research has focused on the development of in vitro BBB models from basic 2D monolayer cultures to 3D cell co-cultures employing different system configurations. Particularly, the use of polymeric hollow fiber membranes (HFs) as scaffolds plays a key role in perfusing 3D dynamic in vitro BBB (DIV-BBB) models. Their incorporation into a perfusion bioreactor system may potentially enhance the vascularization and oxygenation of 3D cell cultures improving cell communication and the exchange of nutrients and metabolites through the microporous membranes. The quest for developing a benchmark 3D dynamic in vitro blood brain barrier model requires the critical assessment of the different aspects that limits the technology. This article will focus on identifying the advantages and main limitations of the HFs in terms of polymer materials, microscopic porous morphology, and other practical issues that play an important role to adequately mimic the physiological environment and recapitulate BBB architecture. Based on this study, we consider that future strategic advances of this technology to become fully implemented as a gold standard DIV-BBB model will require the exploration of novel polymers and/or composite materials, and the optimization of the morphology of the membranes towards thinner HFs (<50 μm) with higher porosities and surface pore sizes of 1-2 µm to facilitate the intercommunication via regulatory factors between the cell co-culture models of the BBB. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Mantecón-Oria, Rivero, Diban and Urtiaga.) |
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| فهرسة مساهمة: | Keywords: blood-brain barrier (BBB); dynamic in vitro (DIV)-BBB models; hollow fiber polymer membranes; microstructural properties; perfusion |
| تواريخ الأحداث: | Date Created: 20221209 Latest Revision: 20221210 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9723404 |
| DOI: | 10.3389/fbioe.2022.1056162 |
| PMID: | 36483778 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-4185 |
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| DOI: | 10.3389/fbioe.2022.1056162 |