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Aniba canelilla (Kunth) Mez essential oil and its primary constituent, 1-nitro-2-phenylethane, inhibits acetylcholinesterase and reverse memory impairment in rodents.

التفاصيل البيبلوغرافية
العنوان: Aniba canelilla (Kunth) Mez essential oil and its primary constituent, 1-nitro-2-phenylethane, inhibits acetylcholinesterase and reverse memory impairment in rodents.
المؤلفون: de Campos DL; Laboratório de Farmacologia da Inflamação e Comportamento, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. Electronic address: daniele.dim94@gmail.com., Queiroz LY; Laboratório de Farmacologia da Inflamação e Comportamento, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. Electronic address: leehyoshitome@gmail.com., Fontes-Junior EA; Laboratório de Farmacologia da Inflamação e Comportamento, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. Electronic address: efontes@ufpa.br., Pinheiro BG; Centro de Ciências Biológicas, Universidade do Estado do Pará, 66087-662, Belém, PA, Brazil. Electronic address: brunogpinheiro1@gmail.com., da Silva JKR; Programa de Pós-Graduação em Química, Universidade Federal do Pará, 66075-900, Belém, PA, Brazil. Electronic address: joycekellys@ufpa.br., Maia CSF; Laboratório de Farmacologia da Inflamação e Comportamento, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. Electronic address: crismaia@ufpa.br., Maia JGS; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil; Programa de Pós-Graduação em Química, Universidade Federal do Maranhão, 65080-040, São Luís, MA, Brazil. Electronic address: gmaia@ufpa.br.
المصدر: Journal of ethnopharmacology [J Ethnopharmacol] 2023 Mar 01; Vol. 303, pp. 116036. Date of Electronic Publication: 2022 Dec 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier Sequoia
Original Publication: Lausanne, Elsevier Sequoia.
مواضيع طبية MeSH: Oils, Volatile*/pharmacology , Oils, Volatile*/therapeutic use , Oils, Volatile*/chemistry , Lauraceae*/chemistry, Rats ; Mice ; Animals ; Acetylcholinesterase/metabolism ; Rodentia/metabolism ; Rats, Wistar ; Donepezil ; Scopolamine ; Memory Disorders/chemically induced ; Memory Disorders/drug therapy ; Maze Learning
مستخلص: Ethnopharmacological Relevance: Aniba canelilla, distributed in the Amazon region, stands out for its diverse economic and medicinal applications. Studies of the A. canelilla essential oil and its primary constituent, 1-nitro-2-phenylethane, have confirmed its anti-inflammatory, antinociceptive, anti-hypertensive potential, and anticholinesterase, among other therapeutic activities.
Aim of the Study: In addition, the present work aims to evaluate the potential of oil and NPE in the learning and memory of rodents.
Material and Methods: The oil was hydrodistilled and analyzed by GC and GC-MS. The learning and memory action in mice was evaluated through the scopolamine-induced cognitive deficit model, followed by behavioral analysis using Morris's water maze paradigm.
Results: Oil provided a yield of 0.5%, and in its chemical composition, 1-nitro-2-phenylethane (NPE) (76.2%) and methyleugenol (19.6%) were identified as primary constituents. Oil fractionation furnished NPE with 99.4%, which was used to evaluate its effects in animal models. Wistar rats were submitted to the mnemonic impairment-scopolamine-induced protocol for 7 days. The oil, NPE, and the positive control donepezil were administered from the 8th to 12th days. Morris water maze results demonstrated that oil and NPE reversed spatial learning and long-term memory similarly induced by muscarinic antagonist scopolamine to donepezil, the positive control.
Conclusion: These beneficial effects have led the work to further investigations of the oil and NPE to elucidate their pharmacological mechanism, focusing on the cholinergic pathway of the central nervous system and opening up to the knowledge of other adjacent mechanisms, whose results are still under analysis.
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: 1-Nitro-2-phenylethane; Aniba canelilla essential oil; Behavioral analysis; Dementia and Alzheimer's disease; Learning and memory
المشرفين على المادة: 0 (Oils, Volatile)
0 (1-nitro-2-phenylethane)
EC 3.1.1.7 (Acetylcholinesterase)
8SSC91326P (Donepezil)
DL48G20X8X (Scopolamine)
تواريخ الأحداث: Date Created: 20221209 Date Completed: 20221228 Latest Revision: 20230103
رمز التحديث: 20231215
DOI: 10.1016/j.jep.2022.116036
PMID: 36493997
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7573
DOI:10.1016/j.jep.2022.116036