دورية أكاديمية
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Nucleus Accumbens D 1 Receptor-Expressing Spiny Projection Neurons Control Food Motivation and Obesity.

التفاصيل البيبلوغرافية
العنوان: Nucleus Accumbens D 1 Receptor-Expressing Spiny Projection Neurons Control Food Motivation and Obesity.
المؤلفون: Matikainen-Ankney BA; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri., Legaria AA; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri; Department of Neuroscience, Washington University in St. Louis, St. Louis, Missouri., Pan Y; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri., Vachez YM; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri., Murphy CA; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri., Schaefer RF; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri., McGrath QJ; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri., Wang JG; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri; Department of Neuroscience, Washington University in St. Louis, St. Louis, Missouri., Bluitt MN; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri., Ankney KC; Department of Economics, Georgetown University, Washington, DC., Norris AJ; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri., Creed MC; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri; Department of Neuroscience, Washington University in St. Louis, St. Louis, Missouri., Kravitz AV; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri; Department of Neuroscience, Washington University in St. Louis, St. Louis, Missouri. Electronic address: alexxai@wustl.edu.
المصدر: Biological psychiatry [Biol Psychiatry] 2023 Mar 15; Vol. 93 (6), pp. 512-523. Date of Electronic Publication: 2022 Oct 21.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Elsevier
Original Publication: New York, Plenum Pub. Corp.
مواضيع طبية MeSH: Nucleus Accumbens*/physiology , Motivation*, Mice ; Animals ; Mice, Obese ; Neurons/physiology ; Obesity ; Receptors, Dopamine D1/metabolism ; Mice, Inbred C57BL
مستخلص: Background: Obesity is a chronic relapsing disorder that is caused by an excess of caloric intake relative to energy expenditure. There is growing recognition that food motivation is altered in people with obesity. However, it remains unclear how brain circuits that control food motivation are altered in obese animals.
Methods: Using a novel behavioral assay that quantifies work during food seeking, in vivo and ex vivo cell-specific recordings, and a synaptic blocking technique, we tested the hypothesis that activity of circuits promoting appetitive behavior in the core of the nucleus accumbens (NAc) is enhanced in the obese state, particularly during food seeking.
Results: We first confirmed that mice made obese with ad libitum exposure to a high fat diet work harder than lean mice to obtain food, consistent with an increase in food motivation in obese mice. We observed greater activation of D 1 receptor-expressing NAc spiny projection neurons (NAc D1 SPNs ) during food seeking in obese mice relative to lean mice. This enhanced activity was not observed in D 2 receptor-expressing neurons (D2 SPNs ). Consistent with these in vivo findings, both intrinsic excitability and excitatory drive onto D1 SPNs were enhanced in obese mice relative to lean mice, and these measures were selective for D1 SPNs . Finally, blocking synaptic transmission from D1 SPNs , but not D2 SPNs , in the NAc core decreased physical work during food seeking and, critically, attenuated high fat diet-induced weight gain.
Conclusions: These experiments demonstrate the necessity of NAc core D1 SPNs in food motivation and the development of diet-induced obesity, establishing these neurons as a potential therapeutic target for preventing obesity.
(Copyright © 2022 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
معلومات مُعتمدة: P30 DK020579 United States DK NIDDK NIH HHS; P30 DK056341 United States DK NIDDK NIH HHS; F32 DK126355 United States DK NIDDK NIH HHS; R21 DA047127 United States DA NIDA NIH HHS; R01 DA049924 United States DA NIDA NIH HHS; T32 GM108539 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: Accumbens; Direct-pathway; Electrophysiology; Food seeking; Motivation; Obesity
المشرفين على المادة: 0 (Receptors, Dopamine D1)
تواريخ الأحداث: Date Created: 20221209 Date Completed: 20230217 Latest Revision: 20230317
رمز التحديث: 20240628
DOI: 10.1016/j.biopsych.2022.10.003
PMID: 36494220
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2402
DOI:10.1016/j.biopsych.2022.10.003