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An Exploratory Study Provides Insights into MMP9 and Aβ Levels in the Vitreous and Blood across Different Ages and in a Subset of AMD Patients.

التفاصيل البيبلوغرافية
العنوان: An Exploratory Study Provides Insights into MMP9 and Aβ Levels in the Vitreous and Blood across Different Ages and in a Subset of AMD Patients.
المؤلفون: Lynn SA; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK., Soubigou F; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK., Dewing JM; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK., Smith A; Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK., Ballingall J; Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK., Sass T; Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK., Nica I; Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK., Watkins C; Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK., Gupta B; Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK., Almuhtaseb H; Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK., Lash SC; Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK., Yuen HM; Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, MP 801, Tremona Road, Southampton SO16 6YD, UK., Cree A; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK., Newman TA; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK., Lotery AJ; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK.; Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK., Ratnayaka JA; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 23; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Matrix Metalloproteinase 9* , Macular Degeneration*, Humans ; Amyloid beta-Peptides ; Biomarkers ; Enzyme-Linked Immunosorbent Assay
مستخلص: Matrix metalloproteinase-9 (MMP9) and total amyloid-beta (Aβ) are prospective biomarkers of ocular ageing and retinopathy. These were quantified by ELISA in the vitreous and blood from controls ( n = 55) and in a subset of age-related macular degeneration (AMD) patients ( n = 12) for insights and possible additional links between the ocular and systemic compartments. Vitreous MMP9 levels in control and AMD groups were 932.5 ± 240.9 pg/mL and 813.7 ± 157.6 pg/mL, whilst serum levels were 2228 ± 193 pg/mL and 2386.8 ± 449.4 pg/mL, respectively. Vitreous Aβ in control and AMD groups were 1173.5 ± 117.1 pg/mL and 1275.6 ± 332.9 pg/mL, whilst plasma Aβ were 574.3 ± 104.8 pg/mL and 542.2 ± 139.9 pg/mL, respectively. MMP9 and Aβ showed variable levels across the lifecourse, indicating no correlation to each other or with age nor AMD status, though the smaller AMD cohort was a limiting factor. Aβ and MMP9 levels in the vitreous and blood were unrelated to mean arterial pressure. Smoking, another modifiable risk, showed no association with vitreous Aβ. However, smoking may be linked with vitreous ( p = 0.004) and serum ( p = 0.005) MMP9 levels in control and AMD groups, though this did not reach our elevated ( p = 0.001) significance. A bioinformatics analysis revealed promising MMP9 and APP/Aβ partners for further scrutiny, many of which are already linked with retinopathy.
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معلومات مُعتمدة: Fight for Sight and Alzheimer's Research UK (Ref: 24AZ172) Fight for Sight; GR590 Retina UK; NC/T002336/1 United Kingdom NC3RS_ National Centre for the Replacement, Refinement and Reduction of Animals in Research; NC/L001152/1 and NC/T002336/1 National Centre for the Replacement Refinement and Reduction of Animals in Research; Grant Support Gift of Sight Appeal; Pump prime awards to S.A.L and J.M.D Alzheimer's Research UK South Coast Network; NC/L001152/1 United Kingdom NC3RS_ National Centre for the Replacement, Refinement and Reduction of Animals in Research
فهرسة مساهمة: Keywords: MMP9; age-related macular degeneration (AMD); amyloid beta (Aβ); biomarkers; lifecourse; lifestyle; mean arterial pressure; smoking
المشرفين على المادة: EC 3.4.24.35 (Matrix Metalloproteinase 9)
0 (Amyloid beta-Peptides)
0 (Biomarkers)
EC 3.4.24.35 (MMP9 protein, human)
تواريخ الأحداث: Date Created: 20221211 Date Completed: 20221216 Latest Revision: 20230315
رمز التحديث: 20230315
مُعرف محوري في PubMed: PMC9736887
DOI: 10.3390/ijms232314603
PMID: 36498929
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms232314603