دورية أكاديمية
أعرض في EDS

Biocompatibility and Biological Performance of Additive-Manufactured Bioabsorbable Iron-Based Porous Interference Screws in a Rabbit Model: A 1-Year Observational Study.

التفاصيل البيبلوغرافية
العنوان: Biocompatibility and Biological Performance of Additive-Manufactured Bioabsorbable Iron-Based Porous Interference Screws in a Rabbit Model: A 1-Year Observational Study.
المؤلفون: Tai CC; International Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan., Huang YM; Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan., Liaw CK; Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Biomedical Optomechantronics, College of Biomedical Engineering, Research Center of Biomedical Device, Taipei Medical University, Taipei 11031, Taiwan., Yang KY; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu 31057, Taiwan., Ma CH; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu 31057, Taiwan., Huang SI; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu 31057, Taiwan., Huang CC; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu 31057, Taiwan., Tsai PI; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu 31057, Taiwan., Shen HH; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu 31057, Taiwan., Sun JS; Department of Orthopedics, China Medical University, Taichung 40202, Taiwan.; School of Medicine, College of Medicine, China Medical University, Taichung 40202, Taiwan., Chen CY; International Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.; Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Biomedical Optomechantronics, College of Biomedical Engineering, Research Center of Biomedical Device, Taipei Medical University, Taipei 11031, Taiwan.; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 23; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 23.
نوع المنشور: Observational Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Iron*/chemistry , Calcium Phosphates*, Animals ; Rabbits ; Porosity ; Absorbable Implants
مستخلص: This study evaluated the mid-term (12-month) biomechanical, biocompatibility, and biological performance of additive-manufactured bioabsorbable iron-based interference screws (ISs). Two bioabsorbable iron IS types-manufactured using pure iron powder (iron_IS) and using pure iron powder with 0.2 wt% tricalcium phosphate (TCP_IS)-were compared with conventional metallic IS (control) using in vitro biocompatibility and degradation analyses and an in vivo animal study. The in vitro ultimate failure strength was significantly higher for iron_IS and TCP_IS than for control ISs at 3 months post-operatively; however, the difference between groups were nonsignificant thereafter. Moreover, at 3 months after implantation, iron_IS and TCP_IS increased bone volume fraction, bone surface area fraction, and percent intersection surface; the changes thereafter were nonsignificant. Iron_IS and TCP_IS demonstrated degradation over time with increased implant surface, decreased implant volume, and structure thickness; nevertheless, the analyses of visceral organs and biochemistry demonstrated normal results, except for time-dependent iron deposition in the spleen. Therefore, compared with conventional ISs, bioabsorbable iron-based ISs exhibit higher initial mechanical strength. Although iron-based ISs demonstrate high biocompatibility 12 months after implantation, their corrosive iron products may accumulate in the spleen. Because they demonstrate mechanical superiority along with considerable absorption capability after implantation, iron-based ISs may have potential applications in implantable medical-device development in the future.
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معلومات مُعتمدة: K356EX3200 Industrial Technology Research Institute; 202056F0026A01 Taipei Medical University-Shuang Ho Hospital (Chih-Yu Chen: New Taipei City, Taiwan)
فهرسة مساهمة: Keywords: additive manufacturing (3D printing); bioabsorbable; interference screw; iron-based
المشرفين على المادة: E1UOL152H7 (Iron)
K4C08XP666 (tricalcium phosphate)
0 (Calcium Phosphates)
تواريخ الأحداث: Date Created: 20221211 Date Completed: 20221216 Latest Revision: 20221222
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9740248
DOI: 10.3390/ijms232314626
PMID: 36498952
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms232314626