دورية أكاديمية
أعرض في EDS

Evaluation of Biocompatibility, Anti-Inflammatory, and Antinociceptive Activities of Pequi Oil-Based Nanoemulsions in In Vitro and In Vivo Models.

التفاصيل البيبلوغرافية
العنوان: Evaluation of Biocompatibility, Anti-Inflammatory, and Antinociceptive Activities of Pequi Oil-Based Nanoemulsions in In Vitro and In Vivo Models.
المؤلفون: Pinheiro AC; Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil.; Post-Graduation Program in Nanoscience and Nanobiotechnology, Institute of Biological Sciences, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília 70910-900, DF, Brazil., Ombredane AS; Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil.; Post-Graduation Program in Nanoscience and Nanobiotechnology, Institute of Biological Sciences, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília 70910-900, DF, Brazil., Pinheiro WO; Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil.; Postgraduate Program in Health Sciences and Technologies, School of Ceilândia, Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil., Andrade LR; Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil.; Post-Graduation Program in Nanoscience and Nanobiotechnology, Institute of Biological Sciences, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília 70910-900, DF, Brazil., Silva VRP; Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil., Felice GJ; Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil., Alves DS; Laboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biological Sciences, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília 70910-900, DF, Brazil., Albernaz AF; Postgraduate Program in Health Sciences and Technologies, School of Ceilândia, Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil., Silveira AP; Laboratory of Microscopy and Microanalysis, Department of Cellular Biology, Institute of Biological Sciences, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília 70910-900, DF, Brazil., Lima MCF; Chemistry Section, Military Institute of Engineering, Praça Gen. Tibúrcio, 80, Praia Vermelha, Rio de Janeiro 22290-270, RJ, Brazil., Veiga-Junior VF; Chemistry Section, Military Institute of Engineering, Praça Gen. Tibúrcio, 80, Praia Vermelha, Rio de Janeiro 22290-270, RJ, Brazil., Gomes TFS; Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil.; Post-Graduation Program in Nanoscience and Nanobiotechnology, Institute of Biological Sciences, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília 70910-900, DF, Brazil., Damasceno EAM; Health Department, Nucleus of Cytopathology and Anatomic Pathology, Regional Hospital of Taguatinga, Taguatinga, Brasilia 72120-970, DF, Brazil., Veiga-Souza FH; Laboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biological Sciences, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília 70910-900, DF, Brazil.; Pharmaceutical Sciences School, Faculty of Ceilândia, Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil., Souza PEN; Laboratory of Electron Paramagnetic Resonance, Institute of Physics, Campus Universitário Darcy Ribeiro, University of Brasília, Brasília 70910-900, DF, Brazil., Báo SN; Laboratory of Microscopy and Microanalysis, Department of Cellular Biology, Institute of Biological Sciences, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília 70910-900, DF, Brazil., Duarte ECB; Department of Pathology, Faculty of Medicine, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília 70910-900, DF, Brazil., Carneiro MLB; Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil.; Post-Graduation Program in Biomedical Engineering-PPGEB, Faculty of Gama-FGA, University of Brasilia, St. Leste Projeção A-Gama Leste, Brasília 72444-240, DF, Brazil., Azevedo RB; Post-Graduation Program in Nanoscience and Nanobiotechnology, Institute of Biological Sciences, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília 70910-900, DF, Brazil., Funez MI; Postgraduate Program in Health Sciences and Technologies, School of Ceilândia, Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil.; Nursing Course, School of Ceilândia, Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil., Joanitti GA; Laboratory of Bioactive Compounds and Nanobiotechnology (LBCNano), Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil.; Post-Graduation Program in Nanoscience and Nanobiotechnology, Institute of Biological Sciences, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília 70910-900, DF, Brazil.; Postgraduate Program in Health Sciences and Technologies, School of Ceilândia, Campus Universitário-Centro Metropolitano, University of Brasilia, Ceilândia Sul, Brasília 72220-275, DF, Brazil.
المصدر: Nanomaterials (Basel, Switzerland) [Nanomaterials (Basel)] 2022 Nov 30; Vol. 12 (23). Date of Electronic Publication: 2022 Nov 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101610216 Publication Model: Electronic Cited Medium: Print ISSN: 2079-4991 (Print) Linking ISSN: 20794991 NLM ISO Abbreviation: Nanomaterials (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2011]-
مستخلص: Pequi oil (Caryocar brasiliense) contains bioactive compounds capable of modulating the inflammatory process; however, its hydrophobic characteristic limits its therapeutic use. The encapsulation of pequi oil in nanoemulsions can improve its biodistribution and promote its immunomodulatory effects. Thus, the objective of the present study was to formulate pequi oil-based nanoemulsions (PeNE) to evaluate their biocompatibility, anti-inflammatory, and antinociceptive effects in in vitro (macrophages—J774.16) and in vivo (Rattus novergicus) models. PeNE were biocompatible, showed no cytotoxic and genotoxic effects and no changes in body weight, biochemistry, or histology of treated animals at all concentrations tested (90−360 µg/mL for 24 h, in vitro; 100−400 mg/kg p.o. 15 days, in vivo). It was possible to observe antinociceptive effects in a dose-dependent manner in the animals treated with PeNE, with a reduction of 27 and 40% in the doses of 100 and 400 mg/kg of PeNE, respectively (p < 0.05); however, the treatment with PeNE did not induce edema reduction in animals with carrageenan-induced edema. Thus, the promising results of this study point to the use of free and nanostructured pequi oil as a possible future approach to a preventive/therapeutic complementary treatment alongside existing conventional therapies for analgesia.
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معلومات مُعتمدة: 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior; 001 National Council for Scientific and Technological Development; 001 Foundation for Research Support of the Federal District
فهرسة مساهمة: Keywords: Caryocar brasiliense; anti-inflammatory; antinociceptive; bioactive compounds; biocompatibility; drug delivery system; nanobiotechnology; nanoemulsion; pequi oil
تواريخ الأحداث: Date Created: 20221211 Latest Revision: 20230308
رمز التحديث: 20230308
مُعرف محوري في PubMed: PMC9740267
DOI: 10.3390/nano12234260
PMID: 36500883
قاعدة البيانات: MEDLINE
الوصف
تدمد:2079-4991
DOI:10.3390/nano12234260