دورية أكاديمية
أعرض في EDS

Metabolically favorable adiposity and bone mineral density: a Mendelian randomization analysis.

التفاصيل البيبلوغرافية
العنوان: Metabolically favorable adiposity and bone mineral density: a Mendelian randomization analysis.
المؤلفون: Bland VL; School of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA., Bea JW; Department of Health Promotion Sciences, University of Arizona, Tucson, Arizona, USA.; The University of Arizona Cancer Center, Tucson, Arizona, USA., Going SB; School of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA., Yaghootkar H; Centre for Inflammation Research and Translational Medicine, Department of Life Sciences, Brunel University London, Uxbridge, UK.; Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK.; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Research, Innovation, Royal Devon & Exeter Hospital, Exeter, UK., Arora A; Department of Epidemiology and Biostatistics, University of Arizona, Tucson, Arizona, USA., Ramadan F; Department of Epidemiology and Biostatistics, University of Arizona, Tucson, Arizona, USA., Funk JL; School of Nutritional Sciences and Wellness, University of Arizona, Tucson, Arizona, USA.; Department of Medicine, University of Arizona, Tucson, Arizona, USA., Chen Z; Department of Epidemiology and Biostatistics, University of Arizona, Tucson, Arizona, USA., Klimentidis YC; Department of Epidemiology and Biostatistics, University of Arizona, Tucson, Arizona, USA.
المصدر: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2023 Jan; Vol. 31 (1), pp. 267-278. Date of Electronic Publication: 2022 Dec 10.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101264860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1930-739X (Electronic) Linking ISSN: 19307381 NLM ISO Abbreviation: Obesity (Silver Spring) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2013- : Malden, MA : John Wiley & Sons
Original Publication: Silver Spring, MD : NAASO, the Obesity Society, c2006-
مواضيع طبية MeSH: Bone Density*/genetics , Mendelian Randomization Analysis*, Humans ; Aged ; Adiposity/genetics ; Absorptiometry, Photon ; Obesity
مستخلص: Objective: This analysis assessed the putative causal association between genetically predicted percent body fat and areal bone mineral density (aBMD) and, more specifically, the association between genetically predicted metabolically "favorable adiposity" (MFA) and aBMD at clinically relevant bone sites.
Methods: Mendelian randomization was used to assess the relationship of MFA and percent body fat with whole-body, lumbar spine, femoral neck, and forearm aBMD. Sex-stratified and age-stratified exploratory analyses were conducted.
Results: In all MR analyses, genetically predicted MFA was inversely associated with aBMD for the whole body (β = -0.053, p = 0.0002), lumbar spine (β = -0.075; p = 0.0001), femoral neck (β = -0.045; p = 0.008), and forearm (β = -0.115; p = 0.001). This negative relationship was strongest in older individuals and did not differ by sex. The relationship between genetically predicted percent body fat and aBMD was nonsignificant across all Mendelian randomization analyses. Several loci that were associated at a genome-wide significance level (p < 5 × 10 -8 ) in opposite directions with body fat and aBMD measures were also identified.
Conclusions: This study did not support the hypothesis that MFA protects against low aBMD. Instead, it showed that MFA may result in lower aBMD. Further research is needed to understand how MFA affects aBMD and other components of bone health such as bone turnover, bone architecture, and osteoporotic fractures.
(© 2022 The Obesity Society.)
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معلومات مُعتمدة: MC_PC_17228 United Kingdom MRC_ Medical Research Council
تواريخ الأحداث: Date Created: 20221211 Date Completed: 20221222 Latest Revision: 20230802
رمز التحديث: 20240628
DOI: 10.1002/oby.23604
PMID: 36502291
قاعدة البيانات: MEDLINE
الوصف
تدمد:1930-739X
DOI:10.1002/oby.23604