دورية أكاديمية
Microwave-assisted extraction of polysaccharide from Cinnamomum cassia with anti-hyperpigmentation properties: Optimization and characterization studies.
| العنوان: | Microwave-assisted extraction of polysaccharide from Cinnamomum cassia with anti-hyperpigmentation properties: Optimization and characterization studies. |
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| المؤلفون: | Al-Ajalein AAS; Analytical Biochemistry Research Centre (ABrC), Universiti Sains Malaysia, University Innovation Incubator Building, SAINS@USM Campus, Lebuh Bukit Jambul, Bayan Lepas, Penang 11900, Malaysia., Shafie MH; Analytical Biochemistry Research Centre (ABrC), Universiti Sains Malaysia, University Innovation Incubator Building, SAINS@USM Campus, Lebuh Bukit Jambul, Bayan Lepas, Penang 11900, Malaysia. Electronic address: hakiminshafie@usm.my., Yap PG; Analytical Biochemistry Research Centre (ABrC), Universiti Sains Malaysia, University Innovation Incubator Building, SAINS@USM Campus, Lebuh Bukit Jambul, Bayan Lepas, Penang 11900, Malaysia., Kassim MA; Bioprocess Division, School of Industrial Technology, Universiti Sains Malaysia, USM, Penang 11800, Malaysia. Electronic address: asyrafkassim@usm.my., Naharudin I; Non-Destructive Biomedical and Pharmaceutical Research Centre, Smart Manufacturing Research Institute, Universiti Teknologi MARA, Puncak Alam, Selangor 42300, Malaysia; Particle Design Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor 42300, Malaysia. Electronic address: idana482@uitm.edu.my., Wong TW; Non-Destructive Biomedical and Pharmaceutical Research Centre, Smart Manufacturing Research Institute, Universiti Teknologi MARA, Puncak Alam, Selangor 42300, Malaysia; Particle Design Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor 42300, Malaysia. Electronic address: wongtinwui@uitm.edu.my., Gan CY; Analytical Biochemistry Research Centre (ABrC), Universiti Sains Malaysia, University Innovation Incubator Building, SAINS@USM Campus, Lebuh Bukit Jambul, Bayan Lepas, Penang 11900, Malaysia. Electronic address: mattgan81@yahoo.com. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2023 Jan 31; Vol. 226, pp. 321-335. Date of Electronic Publication: 2022 Dec 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Antioxidants*/pharmacology , Cinnamomum aromaticum*, Microwaves ; Monophenol Monooxygenase ; Polysaccharides/pharmacology |
| مستخلص: | The anti-hyperpigmentation effect and tyrosinase inhibitory mechanism of cinnamon polysaccharides have not been reported. The current study focused on the extraction of polysaccharides from Cinnamomum cassia bark using microwave-assisted approach and optimization of the extraction process (i.e., microwave power, irradiation time and buffer-to-sample ratio) by Box-Behnken design to obtain a high yield of polysaccharides with high sun protection factor (SPF), anti-hyperpigmentation and antioxidant activities. The extracted pectic-polysaccharides had low molecular weight and degree of esterification. The optimal extraction process had polysaccharides characterized by (a) monophenolase inhibitory activity = 97.5 %; (b) diphenolase inhibitory activity = 99.4 %; (c) ferric reducing antioxidant power = 4.4 mM; (d) SPF = 6.1; (e) yield = 13.7 %. The SPF, tyrosinase inhibitory and antioxidant activities were primarily contributed by the polysaccharides. In conclusion, the polysaccharides from C. cassia could be an alternative therapeutic source for skin hyperpigmentation treatment. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antioxidant; Box–Behnken design; Pectin; Sun protection factor; Tyrosinase inhibitory activity; Yield |
| المشرفين على المادة: | 0 (Antioxidants) EC 1.14.18.1 (Monophenol Monooxygenase) 0 (Polysaccharides) |
| تواريخ الأحداث: | Date Created: 20221212 Date Completed: 20230105 Latest Revision: 20230111 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ijbiomac.2022.12.023 |
| PMID: | 36502951 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2022.12.023 |