دورية أكاديمية
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Untargeted metabolomics screening reveals unique secondary metabolite production from Alternaria section Alternaria .

التفاصيل البيبلوغرافية
العنوان: Untargeted metabolomics screening reveals unique secondary metabolite production from Alternaria section Alternaria .
المؤلفون: Witte TE; Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, Ottawa, ON, Canada., Villenueve N; Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, Ottawa, ON, Canada.; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada., Shields SW; Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, Ottawa, ON, Canada., Sproule A; Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, Ottawa, ON, Canada., Eggertson Q; Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, Ottawa, ON, Canada., Kim NE; Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, Ottawa, ON, Canada., Boddy CN; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada., Dettman JR; Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, Ottawa, ON, Canada., Overy DP; Ottawa Research and Development Centre, Agriculture and Agri-Food Canada, Ottawa, ON, Canada.
المصدر: Frontiers in molecular biosciences [Front Mol Biosci] 2022 Nov 24; Vol. 9, pp. 1038299. Date of Electronic Publication: 2022 Nov 24 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101653173 Publication Model: eCollection Cited Medium: Print ISSN: 2296-889X (Print) Linking ISSN: 2296889X NLM ISO Abbreviation: Front Mol Biosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2014]-
مستخلص: Alternaria section Alternaria is comprised of many species that infect a broad diversity of important crop plants and cause post-harvest spoilage. Alternaria section Alternaria species, such as A. alternata and A. arborescens , are prolific producers of secondary metabolites that act as virulence factors of disease and are mycotoxins that accumulate in infected tissues-metabolites that can vary in their spectrum of production between individuals from the same fungal species. Untargeted metabolomics profiling of secondary metabolite production using mass spectrometry is an effective means to detect phenotypic anomalies in secondary metabolism within a species. Secondary metabolite phenotypes from 36 Alternaria section Alternaria isolates were constructed to observe frequency of production patterns. A clear and unique mass feature pattern was observed for three of the strains that were linked with the production of the dehydrocurvularin family of toxins and associated detoxification products. Examination of corresponding genomes revealed the presence of the dehydrocurvularin biosynthesis gene cluster associated with a sub-telomeric accessory region. A comparison of sequence similarity and occurrences of the dehydrocurvularin biosynthetic gene cluster within Pleosporalean fungi is presented and discussed.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Christopher N. Boddy, and His Majesty the King in Right of Canada, as represented by the Minister of Agriculture and Agri-Food Canada for the contribution of Thomas E. Witte, Nicolas Villeneuve, Sam W. Shields, Amanda Sproule, Quinn Eggertson, Natalie E. Kim, Jeremy R. Dettman and David P. Overy.)
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فهرسة مساهمة: Keywords: Alternaria; accessory region; biosynthetic gene cluster; dehydrocurvularin; fungal plant pathogen; mass spectrometry; secondary metabolites; untargeted metabolomics
تواريخ الأحداث: Date Created: 20221212 Latest Revision: 20221220
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9731300
DOI: 10.3389/fmolb.2022.1038299
PMID: 36504718
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-889X
DOI:10.3389/fmolb.2022.1038299