دورية أكاديمية
Oncological outcomes after simple and skin-sparing mastectomy of ductal carcinoma in situ: A register-based cohort study of 576 Norwegian women.
| العنوان: | Oncological outcomes after simple and skin-sparing mastectomy of ductal carcinoma in situ: A register-based cohort study of 576 Norwegian women. |
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| المؤلفون: | Skjerven HK; Section for Breast and Endocrine Surgery, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address: Helle.skjerven@vestreviken.no., Myklebust EM; Oslo Centre for Biostatistics and Epidemiology, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Research and Innovation, Vestre Viken Hospital Trust, Drammen, Norway., Korvald C; Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway., Porojnicu AC; Section for Oncology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway., Kaaresen R; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Hofvind S; Department of Health and Care Sciences, The Artic University, UiT, Tromsø, Norway; Section for Breast Cancer Screening, Cancer Registry of Norway, Oslo, Norway., Schlicting E; Section for Breast and Endocrine Surgery, Oslo University Hospital, Oslo, Norway., Sahlberg KK; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Research and Innovation, Vestre Viken Hospital Trust, Drammen, Norway. |
| المصدر: | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2023 Mar; Vol. 49 (3), pp. 575-582. Date of Electronic Publication: 2022 Dec 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8504356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2157 (Electronic) Linking ISSN: 07487983 NLM ISO Abbreviation: Eur J Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: London ; New York : Academic Press, [1985- |
| مواضيع طبية MeSH: | Carcinoma, Intraductal, Noninfiltrating*/surgery , Breast Neoplasms*/surgery , Mammaplasty*/methods , Carcinoma, Ductal, Breast*/pathology, Female ; Humans ; Middle Aged ; Mastectomy/methods ; Cohort Studies ; Retrospective Studies ; Neoplasm Recurrence, Local/pathology |
| مستخلص: | Background: For Ductal Carcinoma in Situ (DCIS), recurrence is shown to be higher after skin-sparing (SSM) versus simple (SM) mastectomy. This study aimed to compare the two groups recurrence rates, disease-free survival (DFS), and overall (OS) survival. Methods: We conducted a retrospective register-based cohort study of women operated with SSM (n = 338) or SM (n = 238) for DCIS between 2007 and 2017. Data from the Norwegian Breast Cancer Registry was used to estimate recurrences rates, DFS and OS. Results: Mean age was 51 and 61 years in the SSM and SM groups, respectively. Median follow-up time was 77 months for SSM (range: 21-152 months) vs 84 months for SM (range: 7-171 months). After five years of follow-up, the overall recurrence rate (OR) was 2.1%; 3.9% for SSM and 0.9% for SM. After ten years, the rates were 3.0%, 6.2% for SSM and still 0.9% for SM. DFS was after ten years 92.2%; 91.8% for SSM, and 92.4% for SM. OS was 95.0%; 97.5% for SSM and 93.3% for SM at ten years. For SSM, involved margins represented a significant risk for recurrence. Conclusion: The recurrence rate was higher in the SSM versus the SM group. Whether the difference is due to the operating procedures or underlying risk factors remains unknown. When stratifying for the difference in age, there was no statistical difference in DFS or OS. Involved margins in the SSM group were associated with an increased risk of recurrence. Competing Interests: Declaration of competing interest The authors declare no conflict of interest. (Copyright © 2022 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.) |
| فهرسة مساهمة: | Keywords: DCIS; Disease-free survival; Local recurrence rate; Overall survival; Simple mastectomy; Skin-sparing mastectomy |
| تواريخ الأحداث: | Date Created: 20221212 Date Completed: 20230228 Latest Revision: 20230427 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ejso.2022.11.594 |
| PMID: | 36509629 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-2157 |
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| DOI: | 10.1016/j.ejso.2022.11.594 |