دورية أكاديمية
أعرض في EDS

Sleep and seizure risk in epilepsy: bed and wake times are more important than sleep duration.

التفاصيل البيبلوغرافية
العنوان: Sleep and seizure risk in epilepsy: bed and wake times are more important than sleep duration.
المؤلفون: Stirling RE; Department of Biomedical Engineering, The University of Melbourne, Parkville 3010, Australia.; Research Department, Seer Medical, Melbourne 3000, Australia.; Graeme Clark Institute for Biomedical Engineering, The University of Melbourne, Parkville 3010, Australia., Hidajat CM; Department of Biomedical Engineering, The University of Melbourne, Parkville 3010, Australia., Grayden DB; Department of Biomedical Engineering, The University of Melbourne, Parkville 3010, Australia.; Graeme Clark Institute for Biomedical Engineering, The University of Melbourne, Parkville 3010, Australia.; Department of Medicine, St Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy 3065, Australia., D'Souza WJ; Department of Medicine, St Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy 3065, Australia., Naim-Feil J; Department of Biomedical Engineering, The University of Melbourne, Parkville 3010, Australia., Dell KL; Department of Medicine, St Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy 3065, Australia., Schneider LD; Sleep Health, Alphabet Inc., Mountain View, CA 94043, USA., Nurse E; Research Department, Seer Medical, Melbourne 3000, Australia.; Department of Medicine, St Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy 3065, Australia., Freestone D; Research Department, Seer Medical, Melbourne 3000, Australia., Cook MJ; Research Department, Seer Medical, Melbourne 3000, Australia.; Graeme Clark Institute for Biomedical Engineering, The University of Melbourne, Parkville 3010, Australia.; Department of Medicine, St Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy 3065, Australia., Karoly PJ; Department of Biomedical Engineering, The University of Melbourne, Parkville 3010, Australia.; Research Department, Seer Medical, Melbourne 3000, Australia.; Graeme Clark Institute for Biomedical Engineering, The University of Melbourne, Parkville 3010, Australia.
المصدر: Brain : a journal of neurology [Brain] 2023 Jul 03; Vol. 146 (7), pp. 2803-2813.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Oxford University Press
Original Publication: London.
مواضيع طبية MeSH: Sleep Duration* , Epilepsy*/complications , Epilepsy*/epidemiology, Humans ; Longitudinal Studies ; Electroencephalography ; Sleep ; Seizures/complications
مستخلص: Sleep duration, sleep deprivation and the sleep-wake cycle are thought to play an important role in the generation of epileptic activity and may also influence seizure risk. Hence, people diagnosed with epilepsy are commonly asked to maintain consistent sleep routines. However, emerging evidence paints a more nuanced picture of the relationship between seizures and sleep, with bidirectional effects between changes in sleep and seizure risk in addition to modulation by sleep stages and transitions between stages. We conducted a longitudinal study investigating sleep parameters and self-reported seizure occurrence in an ambulatory at-home setting using mobile and wearable monitoring. Sixty subjects wore a Fitbit smartwatch for at least 28 days while reporting their seizure activity in a mobile app. Multiple sleep features were investigated, including duration, oversleep and undersleep, and sleep onset and offset times. Sleep features in participants with epilepsy were compared to a large (n = 37 921) representative population of Fitbit users, each with 28 days of data. For participants with at least 10 seizure days (n = 34), sleep features were analysed for significant changes prior to seizure days. A total of 4956 reported seizures (mean = 83, standard deviation = 130) and 30 485 recorded sleep nights (mean = 508, standard deviation = 445) were included in the study. There was a trend for participants with epilepsy to sleep longer than the general population, although this difference was not significant. Just 5 of 34 participants showed a significant difference in sleep duration the night before seizure days compared to seizure-free days. However, 14 of 34 subjects showed significant differences between their sleep onset (bed) and/or offset (wake) times before seizure occurrence. In contrast to previous studies, the current study found undersleeping was associated with a marginal 2% decrease in seizure risk in the following 48 h (P < 0.01). Nocturnal seizures were associated with both significantly longer sleep durations and increased risk of a seizure occurring in the following 48 h. Overall, the presented results demonstrated that day-to-day changes in sleep duration had a minimal effect on reported seizures, while patient-specific changes in bed and wake times were more important for identifying seizure risk the following day. Nocturnal seizures were the only factor that significantly increased the risk of seizures in the following 48 h on a group level. Wearables can be used to identify these sleep-seizure relationships and guide clinical recommendations or improve seizure forecasting algorithms.
(© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.)
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فهرسة مساهمة: Keywords: epileptic seizure risk; oversleep; sleep deprivation; sleep–wake cycle; wearables
تواريخ الأحداث: Date Created: 20221213 Date Completed: 20230705 Latest Revision: 20230705
رمز التحديث: 20230705
مُعرف محوري في PubMed: PMC10316760
DOI: 10.1093/brain/awac476
PMID: 36511881
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-2156
DOI:10.1093/brain/awac476