دورية أكاديمية
Antibody effector functions are associated with protection from respiratory syncytial virus.
| العنوان: | Antibody effector functions are associated with protection from respiratory syncytial virus. |
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| المؤلفون: | Bartsch YC; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Cizmeci D; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Kang J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Zohar T; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Periasamy S; Department of Pathology, Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA., Mehta N; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Tolboom J; Janssen Vaccines & Prevention BV, 2333 Leiden, the Netherlands., Van der Fits L; Janssen Vaccines & Prevention BV, 2333 Leiden, the Netherlands., Sadoff J; Janssen Vaccines & Prevention BV, 2333 Leiden, the Netherlands., Comeaux C; Janssen Vaccines & Prevention BV, 2333 Leiden, the Netherlands., Callendret B; Janssen Vaccines & Prevention BV, 2333 Leiden, the Netherlands., Bukreyev A; Department of Pathology, Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA., Lauffenburger DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Bastian AR; Janssen Vaccines & Prevention BV, 2333 Leiden, the Netherlands. Electronic address: ARosema1@its.jnj.com., Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address: galter@mgh.harvard.edu. |
| المصدر: | Cell [Cell] 2022 Dec 22; Vol. 185 (26), pp. 4873-4886.e10. Date of Electronic Publication: 2022 Dec 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge, Ma : Cell Press Original Publication: Cambridge, MIT Press. |
| مواضيع طبية MeSH: | Respiratory Syncytial Virus, Human* , Respiratory Syncytial Virus Infections*/prevention & control, Mice ; Animals ; Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin Fc Fragments ; Viral Fusion Proteins |
| مستخلص: | Respiratory syncytial virus (RSV) infection is a major cause of severe lower respiratory tract infection and death in young infants and the elderly. With no effective prophylactic treatment available, current vaccine candidates aim to elicit neutralizing antibodies. However, binding and neutralization have poorly predicted protection in the past, and accumulating data across epidemiologic cohorts and animal models collectively point to a role for additional antibody Fc-effector functions. To begin to define the humoral correlates of immunity against RSV, here we profiled an adenovirus 26 RSV-preF vaccine-induced humoral immune response in a group of healthy adults that were ultimately challenged with RSV. Protection from infection was linked to opsonophagocytic functions, driven by IgA and differentially glycosylated RSV-specific IgG profiles, marking a functional humoral immune signature of protection against RSV. Furthermore, Fc-modified monoclonal antibodies able to selectively recruit effector functions demonstrated significant antiviral control in a murine model of RSV. Competing Interests: Declaration of interests G.A. is a founder of Seromyx Systems and an equity holder in Leyden Labs. G.A. is on a leave of absence and is currently employed by Moderna Inc. J.T., J.S., L.v.d.F., C.C., B.C., and A.R.B. are employed by Janssen Pharmaceuticals, a Johnson & Johnson company, and may be Johnson & Johnson stockholders. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Cell Host Microbe. 2023 Jan 11;31(1):135-136. (PMID: 36634618) |
| فهرسة مساهمة: | Keywords: Ad26; Fc effector functions; Fc glycosylation; IgA; RSV; antibodies; human challenge study; mAbs; vaccination |
| المشرفين على المادة: | 0 (Antibodies, Neutralizing) 0 (Antibodies, Viral) 0 (Immunoglobulin G) 0 (Immunoglobulin Fc Fragments) 0 (Viral Fusion Proteins) |
| تواريخ الأحداث: | Date Created: 20221213 Date Completed: 20221227 Latest Revision: 20230125 |
| رمز التحديث: | 20230126 |
| DOI: | 10.1016/j.cell.2022.11.012 |
| PMID: | 36513064 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1097-4172 |
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| DOI: | 10.1016/j.cell.2022.11.012 |