دورية أكاديمية
Research progress of L-aspartate-α-decarboxylase and its isoenzyme in the β-alanine synthesis.
العنوان: | Research progress of L-aspartate-α-decarboxylase and its isoenzyme in the β-alanine synthesis. |
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المؤلفون: | Hu ZC; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China., Tian YH; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China., Yang JL; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China., Zhu YN; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China., Zhou HY; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China., Zheng YG; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China., Liu ZQ; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China. microliu@zjut.edu.cn. |
المصدر: | World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2022 Dec 14; Vol. 39 (2), pp. 42. Date of Electronic Publication: 2022 Dec 14. |
نوع المنشور: | Review; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 9012472 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-0972 (Electronic) Linking ISSN: 09593993 NLM ISO Abbreviation: World J Microbiol Biotechnol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2005- : Berlin : Springer Original Publication: Oxford, OX, UK : Published by Rapid Communications of Oxford Ltd in association with UNESCO and in collaboration with the International Union of Microbiological Societies, c1990- |
مواضيع طبية MeSH: | Isoenzymes* , Glutamate Decarboxylase*/metabolism, Aspartic Acid/metabolism ; beta-Alanine |
مستخلص: | Driven by the massive demand in recent years, the production of β-alanine has significantly progressed in chemical and biological ways. Although the chemical method is relatively mature compared to biological synthesis, its high cost of waste disposal and environmental pollution does not meet the environmental protection standard. Hence, the biological method has become more prevalent as a potential alternative to the chemical synthesis of β-alanine in recent years. As a result, the aspartate pathway from L-aspartate to β-alanine (the most significant rate-limiting step in the β-alanine synthesis) catalyzed by L-aspartate-α-decarboxylase (ADC) has become a research hotspot in recent years. Therefore, it is vital to comprehensively understand the different enzymes that possess a similar catalytic ability to ADC. This review will investigate the exploratory process of unique synthesis features and catalytic properties of ADC/ADC-like enzymes in particular creatures with similar catalytic capacity or high sequence homology. At the same time, we will discuss the different β-alanine production methods which can apply to future industrialization. (© 2022. The Author(s), under exclusive licence to Springer Nature B.V.) |
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فهرسة مساهمة: | Keywords: Cysteine sulfinic acid decarboxylase; Enzymatic catalysis; L-Aspartate-α-decarboxylase; Whole-cell catalysis; β-Alanine |
المشرفين على المادة: | EC 4.1.1.11 (aspartate-alpha-decarboxylase) 0 (Isoenzymes) EC 4.1.1.15 (Glutamate Decarboxylase) 30KYC7MIAI (Aspartic Acid) 11P2JDE17B (beta-Alanine) |
تواريخ الأحداث: | Date Created: 20221213 Date Completed: 20221215 Latest Revision: 20221221 |
رمز التحديث: | 20240628 |
DOI: | 10.1007/s11274-022-03483-2 |
PMID: | 36513951 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-0972 |
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DOI: | 10.1007/s11274-022-03483-2 |