دورية أكاديمية
Intra-articular Treatment with Triamcinolone Hexacetonide Associated with Gold Nanoparticles Reduces Cartilage Degeneration in an Animal Model of Osteoarthritis.
| العنوان: | Intra-articular Treatment with Triamcinolone Hexacetonide Associated with Gold Nanoparticles Reduces Cartilage Degeneration in an Animal Model of Osteoarthritis. |
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| المؤلفون: | Dos Santos Haupenthal DP; Laboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, Santa Catarina state, Brazil., Resmini MB; Laboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, Santa Catarina state, Brazil., Da Silva LA; Laboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, Santa Catarina state, Brazil., Colares MC; Laboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, Santa Catarina state, Brazil., de Roch Casagrande L; Laboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, Santa Catarina state, Brazil., Milanez Venturini L; Laboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, Santa Catarina state, Brazil., de Andrade TAM; Graduate Program of Biomedical Science, University Center of Herminio Ometto Foundation, Araras-SP, Brazil., do Bomfim FRC; Department of Biomedical Science University Center of Herminio Ometto Foundation, Araras, Sao Paulo, Brazil., Thirupathi A; Faculty of Sports Science, Ningbo University, Ningbo 315211, China., Emilio Feuser P; Laboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, Santa Catarina state, Brazil., Dal Pizzol F; Laboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, Santa Catarina state, Brazil., Silveira PCL; Laboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, Santa Catarina state, Brazil. |
| المصدر: | Current drug targets [Curr Drug Targets] 2023; Vol. 24 (3), pp. 287-296. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 100960531 Publication Model: Print Cited Medium: Internet ISSN: 1873-5592 (Electronic) Linking ISSN: 13894501 NLM ISO Abbreviation: Curr Drug Targets Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Saif Zone, Sharjah, U. A. E. : Bentham Science Publishers Original Publication: Hilversum, Netherlands ; Boca Raton, FL : Bentham Science Publishers, c2000- |
| مواضيع طبية MeSH: | Cartilage, Articular*/metabolism , Metal Nanoparticles* , Osteoarthritis*/metabolism, Rats ; Animals ; Gold ; Rats, Wistar ; Models, Animal ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Antioxidants/metabolism ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents/metabolism ; Cytokines/metabolism ; Chondrocytes/metabolism ; Chondrocytes/pathology |
| مستخلص: | Introduction: The association between triamcinolone hexacetonide (TH) and gold nanoparticles (GNPs) represents a promising treatment due to the potential anti-inflammatory and antioxidant effects of these compounds. In this study, we evaluated the effects of intra-articular treatment of TH associated with GNPs in a mechanical model of osteoarthritis (OA). Methods: Fifty Wistar rats were divided into five groups: Sham; OA; OA+TH; OA+GNPs; OA+TH-GNPs. Both applications were performed 30 and 60 days after the model was induced. After 30 days of the last application, the animals were euthanized. Results: Only the combined treatment with TH and GNPs promoted a reduction in proinflammatory cytokines and an increase in anti-inflammatory cytokines. The OA+TH-GNPs group obtained a significant reduction in the production of oxidants and oxidative damage markers while an increase in antioxidants. Histologically, all treated groups showed results of a significant increase in cartilage thickness and chondrocyte count, the OA+TH-GNPs group had similar behavior to the group without osteoarthritis, with significantly smaller amounts of chondrocytes than the OA group. Conclusion: The intra-articular use of TH associated with GNPs may be able to prevent the progression of the pathology and minimize joint degradation. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Osteoarthritis; antioxidants; gold nanoparticles; inflammation; oxidative stress; triamcinolone hexacetonide |
| المشرفين على المادة: | I7GT1U99Y9 (triamcinolone hexacetonide) 7440-57-5 (Gold) 0 (Antioxidants) 0 (Anti-Inflammatory Agents) 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20221214 Date Completed: 20230316 Latest Revision: 20230321 |
| رمز التحديث: | 20230321 |
| DOI: | 10.2174/1389450124666221212090319 |
| PMID: | 36515017 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1873-5592 |
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| DOI: | 10.2174/1389450124666221212090319 |