دورية أكاديمية
Moving beyond standard toxicological metrics: The effect of diclofenac on planktonic host-parasite interactions.
| العنوان: | Moving beyond standard toxicological metrics: The effect of diclofenac on planktonic host-parasite interactions. |
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| المؤلفون: | Vasantha Raman N; Department of Aquatic Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10, Wageningen, PB 6708, the Netherlands. Electronic address: N.Raman@nioo.knaw.nl., Gsell AS; Department of Aquatic Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10, Wageningen, PB 6708, the Netherlands., Voulgarellis T; Department of Aquatic Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10, Wageningen, PB 6708, the Netherlands., van den Brink NW; Division of Toxicology, Wageningen University & Research, Stippeneng 4, Wageningen, WE 6708, the Netherlands., de Senerpont Domis LN; Department of Aquatic Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10, Wageningen, PB 6708, the Netherlands; Aquatic Ecology and Water Quality Management Group, Wageningen University & Research, Wageningen, the Netherlands; Pervasive Systems Research Group, Faculty of Electrical Engineering, Mathematics and Computer Science, University of Twente, the Netherlands; Department of Water Resources, Faculty of Geo-Information Science and Earth Observation, University of Twente, the Netherlands. |
| المصدر: | Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2023 Jan; Vol. 254, pp. 106370. Date of Electronic Publication: 2022 Dec 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8500246 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1514 (Electronic) Linking ISSN: 0166445X NLM ISO Abbreviation: Aquat Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Netherlands : Elsevier/North Holland Biomedical Press, c1981- |
| مواضيع طبية MeSH: | Water Pollutants, Chemical*/toxicity , Parasites*, Animals ; Host-Parasite Interactions ; Plankton ; Diclofenac/toxicity ; Ecosystem ; Phytoplankton ; Pharmaceutical Preparations |
| مستخلص: | Pharmaceuticals are increasingly released into surface waters and therefore ubiquitous in aquatic systems. While pharmaceuticals are known to influence species interactions, their effect on host-parasite interactions is still underexplored despite potential ecosystem-level consequences. Here, we ask whether diclofenac, a widely used non-steroid anti-inflammatory drug, affects the interaction between a phytoplankton host (Staurastrum sp.; green alga) and its obligate fungal parasite (Staurastromyces oculus; chytrid fungus). We hypothesized that the effect of increasing diclofenac concentration on the host-parasite system depends on parasite exposure. We assessed acute and chronic effects of a wide range of diclofenac concentrations (0-150 mg/L) on host and parasite performance using a replicated long gradient design in batch cultures. Overall system response summarizing parameters related to all biotic components in an experimental unit i.e., number of bacteria and phytoplankton host cells along with photosynthetic yield (a measure of algal cell fitness), depended on diclofenac concentration and presence/absence of parasite. While host standing biomass decreased at diclofenac concentrations >10 mg/L in non-parasite-exposed treatments, it increased at ≥10 mg/L in parasite-exposed treatments since losses due to infection declined. During acute phase (0-48 h), diclofenac concentrations <0.1 mg/L had no effect on host net-production neither in parasite-exposed nor non-parasite-exposed treatments, but parasite infection ceased at 10 mg/L. During chronic phase (0-216 h), host net-production declined only at concentrations >10 mg/L in non-parasite-exposed cultures, while it was overall close to zero in parasite-exposed cultures. Our results suggest that chytrid parasites are more sensitive to diclofenac than their host, allowing a window of opportunity for growth of phytoplankton hosts, despite exposure to a parasite. Our work provides a first understanding about effects of a pharmaceutical on a host-parasite interaction beyond those defined by standard toxicological metrics. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Chytrid; Diclofenac; Direct effects; Host-parasite interaction; Indirect effects |
| المشرفين على المادة: | 144O8QL0L1 (Diclofenac) 0 (Water Pollutants, Chemical) 0 (Pharmaceutical Preparations) |
| تواريخ الأحداث: | Date Created: 20221214 Date Completed: 20230103 Latest Revision: 20230103 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.aquatox.2022.106370 |
| PMID: | 36516501 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1514 |
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| DOI: | 10.1016/j.aquatox.2022.106370 |