دورية أكاديمية
Probiotic Therapy During Vaccination Alters Antibody Response to Simian-Human Immunodeficiency Virus Infection But Not to Commensals.
| العنوان: | Probiotic Therapy During Vaccination Alters Antibody Response to Simian-Human Immunodeficiency Virus Infection But Not to Commensals. |
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| المؤلفون: | Wilson A; Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, George Washington University, Washington, District of Columbia, USA., Manuzak JA; Division of Immunology, Tulane National Primate Research Center, Covington, Louisiana, USA., Liang H; Department of Statistics, George Washington University, Washington, District of Columbia, USA., Leda AR; Department of Microbiology and Immunology, Scripps Biomedical Research, University of Florida, Jupiter, Florida, USA., Klatt N; Department of Surgery, Division of Surgical Outcomes and Precision Medicine Research, University of Minnesota, Minneapolis, Minnesota, USA., Lynch RM; Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, George Washington University, Washington, District of Columbia, USA. |
| المصدر: | AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2023 May; Vol. 39 (5), pp. 222-231. Date of Electronic Publication: 2023 Feb 03. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8709376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-8405 (Electronic) Linking ISSN: 08892229 NLM ISO Abbreviation: AIDS Res Hum Retroviruses Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: [New York] : Mary Ann Liebert, [c1987- |
| مواضيع طبية MeSH: | HIV Infections*/prevention & control , Simian Immunodeficiency Virus* , HIV-1* , Simian Acquired Immunodeficiency Syndrome*/prevention & control , AIDS Vaccines*, Animals ; Humans ; Antibody Formation ; Macaca mulatta ; Vaccination |
| مستخلص: | The induction of robust circulating antibody titers is a key goal of HIV-1 vaccination. Probiotic supplementation is an established strategy to enhance microbiota and boost antibody responses to vaccines. A recent study tested whether oral probiotics could enhance vaccine-specific mucosal immunity by testing vaccination with and without supplementation in a Rhesus macaque Simian-Human Immunodeficiency Virus challenge model. Although supplementation was not associated with protection, the effects of probiotics on immunity after infection were not examined. To address this question, we measured antibody titers to HIV Env and commensal bacteria in plasma from the vaccination/supplementation time points as well as after Simian-Human Immunodeficiency Virus (SHIV) acquisition. We found that a trend toward lower HIV Env-specific titers in the animals given probiotics plus vaccine became greater after SHIV infection. Significantly lower Immunoglobulin (Ig) A titers were observed in animals vaccinated and supplemented compared with vaccine alone due to a delay in antibody kinetics at week 2 postinfection. We observed no difference, however, in titers to commensal bacteria during probiotic supplementation or after SHIV infection. These results suggest that probiotic supplementation may be a strategy for reducing IgA-specific HIV antibodies in the plasma, a correlate associated with increased HIV infection in the RV144 clinical trial. |
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| معلومات مُعتمدة: | R21 OD031435 United States OD NIH HHS; R21 AI140788 United States AI NIAID NIH HHS; R01 HD108015 United States HD NICHD NIH HHS; P30 AI117970 United States AI NIAID NIH HHS; P51 OD011104 United States OD NIH HHS; R01 AI120712 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: HIV vaccine; SHIV; antibodies; commensal bacteria; probiotic |
| المشرفين على المادة: | 0 (AIDS Vaccines) |
| تواريخ الأحداث: | Date Created: 20221215 Date Completed: 20230511 Latest Revision: 20240502 |
| رمز التحديث: | 20240502 |
| مُعرف محوري في PubMed: | PMC10171943 |
| DOI: | 10.1089/AID.2022.0123 |
| PMID: | 36517984 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1931-8405 |
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| DOI: | 10.1089/AID.2022.0123 |