دورية أكاديمية
From Oxetane to Thietane: Extending the Antiviral Spectrum of 2'-Spirocyclic Uridines by Substituting Oxygen with Sulfur.
| العنوان: | From Oxetane to Thietane: Extending the Antiviral Spectrum of 2'-Spirocyclic Uridines by Substituting Oxygen with Sulfur. |
|---|---|
| المؤلفون: | Grosse S; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Tahri A; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Raboisson P; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Houpis Y; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Stoops B; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Jacoby E; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Neefs JM; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Van Loock M; Janssen Global Public Health, R&D, Turnhoutseweg 30, 2340 Beerse, Belgium., Goethals O; Janssen Global Public Health, R&D, Turnhoutseweg 30, 2340 Beerse, Belgium., Geluykens P; Charles River, Discovery, Turnhoutseweg 30, 2340 Beerse, Belgium., Bonfanti JF; Janssen Research and Development, Chaussée du Vexin, 27100 Val de Reuil, France., Jonckers THM; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium. |
| المصدر: | ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Nov 28; Vol. 13 (12), pp. 1879-1884. Date of Electronic Publication: 2022 Nov 28 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society |
| مستخلص: | In continuation of our efforts of finding novel nucleoside inhibitors for the treatment of viral diseases, we initiated a discovery research program aimed at identifying novel nucleos(t)ide inhibitors for emerging diseases like Dengue and Chikungunya. Based on the previously reported 2'-spiro-oxetane uridine derivatives active against Hepatitis C Virus (HCV), we envisaged its sulfur analogue as an interesting congener both from a synthetic as well as biological point of view. Surprisingly, we found the 2'-spirothietane uridine derivatives not only to be active against HCV and Dengue virus (DENV), viruses belonging to the flavivirus family, but also to demonstrate activity against alphaviruses like Chikungunya virus (CHIKV) and Sindbis virus (SINV). Competing Interests: The authors declare no competing financial interest. (© 2022 American Chemical Society.) |
| References: | J Org Chem. 2008 Jun 6;73(11):4305-8. (PMID: 18433176) J Med Chem. 2016 Jun 23;59(12):5790-8. (PMID: 27181575) J Med Chem. 2014 Mar 13;57(5):1836-44. (PMID: 24345201) Org Lett. 2007 Nov 22;9(24):5007-9. (PMID: 17975917) Beilstein J Org Chem. 2020 Jun 22;16:1357-1410. (PMID: 32647542) J Med Chem. 2010 Nov 25;53(22):8150-60. (PMID: 21033671) RSC Med Chem. 2020 Dec 23;12(3):306-320. (PMID: 34046618) Acc Chem Res. 2022 Feb 15;55(4):565-578. (PMID: 35077644) J Phys Chem A. 2009 Nov 19;113(46):12763-73. (PMID: 19831376) J Biol Chem. 2008 Mar 21;283(12):7705-12. (PMID: 18184655) Annu Rev Med. 2018 Jan 29;69:395-408. (PMID: 28846489) J Med Chem. 2021 Jan 14;64(1):150-183. (PMID: 33381970) Molecules. 2021 Feb 09;26(4):. (PMID: 33572409) J Org Chem. 2014 Jun 20;79(12):5627-35. (PMID: 24873952) Hepatology. 2020 Feb;71(2):686-721. (PMID: 31816111) Annu Rep Med Chem. 2021;57:109-132. (PMID: 34728865) J Med Chem. 2020 Sep 24;63(18):10380-10395. (PMID: 32816483) J Hepatol. 2020 Nov;73(5):1170-1218. (PMID: 32956768) Bioorg Med Chem Lett. 2018 Jul 15;28(13):2324-2327. (PMID: 29801997) Bioorg Med Chem Lett. 2012 May 1;22(9):3265-8. (PMID: 22472694) J Org Chem. 2011 Jan 7;76(1):297-300. (PMID: 21133352) J Med Chem. 2010 Oct 14;53(19):7202-18. (PMID: 20845908) Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20435-9. (PMID: 19918064) J Org Chem. 2021 Dec 3;86(23):17344-17361. (PMID: 34748342) Antiviral Res. 2015 Apr;116:1-9. (PMID: 25614455) Sci Transl Med. 2022 Jan 19;14(628):eabl7430. (PMID: 34941423) Chem Rev. 2014 Aug 27;114(16):8257-322. (PMID: 25003801) Chem Rev. 2014 Sep 24;114(18):9154-218. (PMID: 25144792) J Med Chem. 2014 Mar 13;57(5):1826-35. (PMID: 24079820) J Org Chem. 1976 Sep 3;41(18):3010-7. (PMID: 134137) J Pharm Sci. 2012 Oct;101(10):3979-88. (PMID: 22833171) Science. 2015 Feb 13;347(6223):771-5. (PMID: 25678663) Int J Mol Sci. 2015 Jun 08;16(6):12943-57. (PMID: 26062131) ACS Med Chem Lett. 2021 Mar 29;12(4):510-517. (PMID: 33854700) |
| تواريخ الأحداث: | Date Created: 20221215 Latest Revision: 20231212 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9743439 |
| DOI: | 10.1021/acsmedchemlett.2c00372 |
| PMID: | 36518706 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1948-5875 |
|---|---|
| DOI: | 10.1021/acsmedchemlett.2c00372 |