دورية أكاديمية
Fibroblastic reticular cells orchestrate long-term graft survival following recipient treatment with CD40 ligand-targeted costimulatory blockade.
العنوان: | Fibroblastic reticular cells orchestrate long-term graft survival following recipient treatment with CD40 ligand-targeted costimulatory blockade. |
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المؤلفون: | Fairchild RL |
المصدر: | The Journal of clinical investigation [J Clin Invest] 2022 Dec 15; Vol. 132 (24). Date of Electronic Publication: 2022 Dec 15. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation Original Publication: New Haven [etc.] American Society for Clinical Investigation. |
مواضيع طبية MeSH: | CD40 Ligand* , Graft Survival*, Mice ; Animals ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; T-Lymphocytes ; Antibodies, Monoclonal/pharmacology ; CD40 Antigens ; Graft Rejection |
مستخلص: | Fibroblastic reticular cells (FRCs) maintain the architecture of secondary lymphoid organs, which optimize interactions between antigen-presenting dendritic cells and reactive naive T cells. In this issue of the JCI, Zhao, Jung, and colleagues investigated CD4+FoxP3+ regulatory T cell development and long-term heart allograft survival in recipients treated with peritransplant costimulatory blockade to inhibit CD40/CD40 ligand (CD40L) signaling. Treatment with an anti-CD40L monoclonal antibody (mAb) increased the lymph node (LN) population of Madcam1+ FRCs and altered their transcription profile to express immunoregulatory mediators. Administration of nanoparticles, containing the anti-CD40L mAb and a targeting antibody against high endothelial venules, delivered the treatment into LNs of allograft recipients. Direct LN delivery of the costimulatory blockade allowed decreased dosing and increased the efficacy in extending graft survival. The results provide insights into mechanisms by which FRCs can promote donor-reactive tolerance, and establish a strategy for administering costimulation-blocking reagents that circumvent systemic effects and improve allograft outcomes. |
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المشرفين على المادة: | 147205-72-9 (CD40 Ligand) 0 (Antibodies, Monoclonal) 0 (CD40 Antigens) |
تواريخ الأحداث: | Date Created: 20221215 Date Completed: 20221216 Latest Revision: 20221223 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9753987 |
DOI: | 10.1172/JCI165174 |
PMID: | 36519546 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1558-8238 |
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DOI: | 10.1172/JCI165174 |