دورية أكاديمية
FGF4 Promotes Skin Wound Repair through p38 MAPK and GSK3β-Mediated Stabilization of Slug.
| العنوان: | FGF4 Promotes Skin Wound Repair through p38 MAPK and GSK3β-Mediated Stabilization of Slug. |
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| المؤلفون: | Sun J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China., Zhou J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China., Zhou J; Department of Pediatrics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China., Xu W; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China., Du Y; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China., Jia Z; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China., Shen Y; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China; School of Life Sciences, Huzhou University, Huzhou, China., Lin X; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China., Wang X; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China., Bao Y; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China., Rao Z; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China., Dong S; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China., Luo Y; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China., Cong W; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China., Jin L; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China., Li X; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China. Electronic address: xiaokunli@wmu.edu.cn. |
| المصدر: | The Journal of investigative dermatology [J Invest Dermatol] 2023 Jun; Vol. 143 (6), pp. 1073-1084.e8. Date of Electronic Publication: 2022 Dec 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York : Elsevier Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Gastropoda*, Mice ; Animals ; Humans ; Glycogen Synthase Kinase 3 beta ; Wound Healing/physiology ; Skin/injuries ; Keratinocytes/physiology ; Re-Epithelialization ; Disease Models, Animal ; Cell Movement ; Fibroblast Growth Factor 4 |
| مستخلص: | Cutaneous wound healing is an orderly and intricate process that restores the barrier function and integrity of injured skin. Re-epithelialization, which involves the proliferation and migration of keratinocytes to cover the denuded surface, is essential for successful wound closure. There are many members of the FGF family, of which the paracrine-acting FGF1 and FGF7 subfamily members have been identified as positive regulators of wound repair. However, the role and underlying mechanisms of some other paracrine FGFs in wound repair still remain obscure. In this report, we found that paracrine FGF4 localized predominantly to the epidermal keratinocytes and was markedly upregulated at the wound edges in response to re-epithelialization in human and mouse wound models. Blockade of FGF4 resulted in delayed re-epithelialization of human ex vivo skin wounds, whereas recombinant FGF4 treatment promoted re-epithelialization and wound repair. Mechanistically, recombinant FGF4 promotes p38 MAPK‒GSK3β‒mediated stabilization of Slug by reducing its ubiquitination, which triggers epithelial-to-mesenchymal transition and promotes the migration and proliferation of keratinocytes and thus wound re-epithelialization. Our findings uncover FGF4 as an important regulator of wound healing, highlighting a promising therapeutic avenue for skin injury. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta) 0 (FGF4 protein, human) 0 (Fibroblast Growth Factor 4) |
| تواريخ الأحداث: | Date Created: 20221215 Date Completed: 20230523 Latest Revision: 20230620 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jid.2022.11.015 |
| PMID: | 36521556 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1523-1747 |
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| DOI: | 10.1016/j.jid.2022.11.015 |