دورية أكاديمية
أعرض في EDS

Defining the window of opportunity and target populations to prevent peanut allergy.

التفاصيل البيبلوغرافية
العنوان: Defining the window of opportunity and target populations to prevent peanut allergy.
المؤلفون: Roberts G; University of Southampton and Southampton NIHR Biomedical Research Centre, Southampton, and the David Hide Centre, Isle of Wight, United Kingdom., Bahnson HT; Benaroya Research Institute and the Immune Tolerance Network, Seattle, Wash., Du Toit G; Pediatric Allergy Group, Department of Women and Children's Health, School of Life Course Sciences, King's College, and the Children's Allergy Service, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., O'Rourke C; Benaroya Research Institute and the Immune Tolerance Network, Seattle, Wash., Sever ML; Rho Federal Systems Division, Durham, and PPD Government and Public Health Services, Wilmington, NC., Brittain E; National Institute of Allergy and Infectious Diseases, Bethesda, Md., Plaut M; National Institute of Allergy and Infectious Diseases, Bethesda, Md., Lack G; Pediatric Allergy Group, Department of Women and Children's Health, School of Life Course Sciences, King's College, and the Children's Allergy Service, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. Electronic address: gideon.lack@kcl.ac.uk.
المصدر: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2023 May; Vol. 151 (5), pp. 1329-1336. Date of Electronic Publication: 2022 Dec 12.
نوع المنشور: Observational Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: St Louis, Mosby.
مواضيع طبية MeSH: Peanut Hypersensitivity*/epidemiology , Peanut Hypersensitivity*/prevention & control , Peanut Hypersensitivity*/diagnosis , Eczema*, Infant ; Child ; Humans ; Risk ; Diet ; Arachis ; Allergens ; Randomized Controlled Trials as Topic
مستخلص: Background: Peanut allergy affects 1% to 2% of European children. Early introduction of peanut into the diet reduces allergy in high-risk infants.
Objective: We aimed to determine the optimal target populations and timing of introduction of peanut products to prevent peanut allergy in the general population.
Methods: Data from the Enquiring About Tolerance (EAT; n = 1303; normal risk; 3-year follow-up; ISRCTN14254740) and Learning Early About Peanut Allergy study (LEAP; n = 640; high risk; 5-year follow-up; NCT00329784) randomized controlled trials plus the Peanut Allergy Sensitization (PAS; n = 194; low and very high risk; 5-year follow-up) observational study were used to model the intervention in a general population. Peanut allergy was defined by blinded peanut challenge or diagnostic skin prick test result.
Results: Targeting only the highest-risk infants with severe eczema reduced the population disease burden by only 4.6%. Greatest reductions in peanut allergy were seen when the intervention was targeted only to the larger but lower-risk groups. A 77% reduction in peanut allergy was estimated when peanut was introduced to the diet of all infants, at 4 months with eczema, and at 6 months without eczema. The estimated reduction in peanut allergy diminished with every month of delayed introduction. If introduction was delayed to 12 months, peanut allergy was only reduced by 33%.
Conclusions: The preventive benefit of early introduction of peanut products into the diet decreases as age at introduction increases. In countries where peanut allergy is a public health concern, health care professionals should help parents introduce peanut products into their infants' diet at 4 to 6 months of life.
(Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
التعليقات: Comment in: J Allergy Clin Immunol. 2023 May;151(5):1246-1248. (PMID: 36796455)
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معلومات مُعتمدة: UM2 AI117870 United States AI NIAID NIH HHS; NIHRCS/01/2008/009 United Kingdom DH_ Department of Health; MC_G1001205 United Kingdom MRC_ Medical Research Council; N01AI15416 United States AI NIAID NIH HHS; HHSN272200800029C United States AI NIAID NIH HHS; UM1 AI109565 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Peanut allergy; diet; early introduction; population; prevention
سلسلة جزيئية: ISRCTN ISRCTN14254740
ClinicalTrials.gov NCT00329784
المشرفين على المادة: 0 (Allergens)
تواريخ الأحداث: Date Created: 20221215 Date Completed: 20230508 Latest Revision: 20240306
رمز التحديث: 20240306
مُعرف محوري في PubMed: PMC10689252
DOI: 10.1016/j.jaci.2022.09.042
PMID: 36521802
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-6825
DOI:10.1016/j.jaci.2022.09.042