دورية أكاديمية
أعرض في EDS

Consolidative mediastinal radiotherapy for advanced-stage classical Hodgkin lymphoma with bulky disease in patients who achieve complete response after chemotherapy in PET-CT era.

التفاصيل البيبلوغرافية
العنوان: Consolidative mediastinal radiotherapy for advanced-stage classical Hodgkin lymphoma with bulky disease in patients who achieve complete response after chemotherapy in PET-CT era.
المؤلفون: Atanazio MJ; Instituto do Cancer do Estado de São Paulo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Santos FM; Instituto do Cancer do Estado de São Paulo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Duran A; Instituto do Cancer do Estado de São Paulo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Maia ACA; Instituto do Cancer do Estado de São Paulo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Alves LB; Instituto do Cancer do Estado de São Paulo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Velasques RD; Instituto do Cancer do Estado de São Paulo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Rocha V; Instituto do Cancer do Estado de São Paulo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Buccheri V; Instituto do Cancer do Estado de São Paulo, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
المصدر: Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology [Rep Pract Oncol Radiother] 2022 Oct 31; Vol. 27 (5), pp. 856-862. Date of Electronic Publication: 2022 Oct 31 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Via Medica Country of Publication: Poland NLM ID: 100885761 Publication Model: eCollection Cited Medium: Print ISSN: 1507-1367 (Print) Linking ISSN: 15071367 NLM ISO Abbreviation: Rep Pract Oncol Radiother Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2021- : Gdańsk, Poland : Via Medica
Original Publication: Poznań : Greatpoland Cancer Center and Polish Society of Radiation Oncology, 1998-
مستخلص: Background: The role of consolidation mediastinal radiotherapy (RT) for mediastinal bulky disease in advanced-stage classical Hodgkin lymphoma (cHL) is controversial in the positron emission tomography/computed tomography (PET-CT) era.
Materials and Methods: We reviewed the medical charts of patients with advanced-stage (clinical stage IIX-IVX) cHL and mediastinal bulky that achieved a complete response after first line chemotherapy treatment between August 2010 and December 2020 and compared the results of those who received with those who did not receive consolidation mediastinal RT. Inclusion criteria required PET-CT imaging for staging and response assessment.
Results: We included 115 patients; 91 received mediastinal RT and 24 did not. Patient's characteristics were balanced between the two groups. The median age in patients that received and did not receive mediastinal RT was 28 years and 24.5 years, respectively. Median International Prognostic Score among patients that received and did not receive mediastinal RT was 2 and 2.5, respectively. Disease free survival (DFS) was statistically better in patients that received mediastinal RT (p = 0.013). Two-year DFS for patients that received and did not receive mediastinal RT was 95.2% [95% confidence interval (95% CI): 87.6-98.2%] and 76.4% (95% CI: 52.2-89.4%), respectively. Overall survival (OS) was not different between the two groups (p = 0.617). In multivariate analysis, not receiving mediastinal radiotherapy and only achieving partial response ( vs. complete response) after 2 cycles of chemotherapy were factors predictive of lower DFS.
Conclusion: DFS, but not OS, was superior in patients that received mediastinal RT.
Competing Interests: Conflict of interest The authors state that they have no conflict of interests
(© 2022 Greater Poland Cancer Centre.)
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فهرسة مساهمة: Keywords: Hodgkin’s lymphoma; positron emission tomography; radiotherapy
تواريخ الأحداث: Date Created: 20221216 Latest Revision: 20221222
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9746642
DOI: 10.5603/RPOR.a2022.0092
PMID: 36523799
قاعدة البيانات: MEDLINE
الوصف
تدمد:1507-1367
DOI:10.5603/RPOR.a2022.0092