دورية أكاديمية
أعرض في EDS

Focal electrical stimulation of human retinal ganglion cells for vision restoration.

التفاصيل البيبلوغرافية
العنوان: Focal electrical stimulation of human retinal ganglion cells for vision restoration.
المؤلفون: Madugula SS; Neurosciences PhD Program, Stanford University, Stanford, CA, United States of America.; School of Medicine, Stanford University, Stanford, CA, United States of America.; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, United States of America., Gogliettino AR; Neurosciences PhD Program, Stanford University, Stanford, CA, United States of America.; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, United States of America., Zaidi M; Department of Neurosurgery, Stanford University, Stanford, CA, United States of America.; School of Medicine, Stanford University, Stanford, CA, United States of America.; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, United States of America., Aggarwal G; Department of Neurosurgery, Stanford University, Stanford, CA, United States of America.; Department of Electrical Engineering, Stanford University, Stanford, CA, United States of America.; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, United States of America., Kling A; Department of Neurosurgery, Stanford University, Stanford, CA, United States of America.; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, United States of America., Shah NP; Department of Neurosurgery, Stanford University, Stanford, CA, United States of America.; Department of Electrical Engineering, Stanford University, Stanford, CA, United States of America.; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, United States of America., Brown JB; Department of Electrical Engineering, Stanford University, Stanford, CA, United States of America., Vilkhu R; Department of Electrical Engineering, Stanford University, Stanford, CA, United States of America., Hays MR; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, United States of America.; Department of Bioengineering, Stanford University, Stanford, CA, United States of America., Nguyen H; Department of Neurosurgery, Stanford University, Stanford, CA, United States of America., Fan V; Department of Neurosurgery, Stanford University, Stanford, CA, United States of America., Wu EG; Department of Electrical Engineering, Stanford University, Stanford, CA, United States of America.; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, United States of America., Hottowy P; Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow, Poland., Sher A; Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA, United States of America., Litke AM; Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA, United States of America., Silva RA; Department of Ophthalmology, Stanford University, Stanford, CA, United States of America., Chichilnisky EJ; Department of Neurosurgery, Stanford University, Stanford, CA, United States of America.; Department of Ophthalmology, Stanford University, Stanford, CA, United States of America.; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, United States of America.
المصدر: Journal of neural engineering [J Neural Eng] 2022 Dec 19; Vol. 19 (6). Date of Electronic Publication: 2022 Dec 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Institute of Physics Pub Country of Publication: England NLM ID: 101217933 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-2552 (Electronic) Linking ISSN: 17412552 NLM ISO Abbreviation: J Neural Eng Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Bristol, U.K. : Institute of Physics Pub., 2004-
مواضيع طبية MeSH: Retinal Ganglion Cells*/physiology , Visual Prosthesis*, Animals ; Humans ; Electric Stimulation/methods ; Retina/physiology ; Electrodes ; Macaca ; Action Potentials/physiology ; Photic Stimulation/methods
مستخلص: Objective . Vision restoration with retinal implants is limited by indiscriminate simultaneous activation of many cells and cell types, which is incompatible with reproducing the neural code of the retina. Recent work has shown that primate retinal ganglion cells (RGCs), which transmit visual information to the brain, can be directly electrically activated with single-cell, single-spike, cell-type precision - however, this possibility has never been tested in the human retina. In this study we aim to characterize, for the first time, direct in situ extracellular electrical stimulation of individual human RGCs. Approach . Extracellular electrical stimulation of individual human RGCs was conducted in three human retinas ex vivo using a custom large-scale, multi-electrode array capable of simultaneous recording and stimulation. Measured activation properties were compared directly to extensive results from macaque. Main results . Precise activation was in many cases possible without activating overlying axon bundles, at low stimulation current levels similar to those used in macaque. The major RGC types could be identified and targeted based on their distinctive electrical signatures. The measured electrical activation properties of RGCs, combined with a dynamic stimulation algorithm, was sufficient to produce an evoked visual signal that was nearly optimal given the constraints of the interface. Significance . These results suggest the possibility of high-fidelity vision restoration in humans using bi-directional epiretinal implants.
(© 2022 IOP Publishing Ltd.)
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معلومات مُعتمدة: R01 EY021271 United States EY NEI NIH HHS; P30 EY026877 United States EY NEI NIH HHS; T32 MH020016 United States MH NIMH NIH HHS; R01 EY032900 United States EY NEI NIH HHS; R01 EY033870 United States EY NEI NIH HHS; F30 EY030776 United States EY NEI NIH HHS; P30 EY019005 United States EY NEI NIH HHS; R01 EY029247 United States EY NEI NIH HHS
فهرسة مساهمة: Keywords: epiretinal implants; extracellular electrical stimulation; multi-electrode arrays; retina; translational neuro-rehabilitation
تواريخ الأحداث: Date Created: 20221219 Date Completed: 20221220 Latest Revision: 20240914
رمز التحديث: 20240914
مُعرف محوري في PubMed: PMC10010036
DOI: 10.1088/1741-2552/aca5b5
PMID: 36533865
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-2552
DOI:10.1088/1741-2552/aca5b5