دورية أكاديمية

Cancer of the Liver and its Relationship with Diabetes mellitus.

التفاصيل البيبلوغرافية
العنوان: Cancer of the Liver and its Relationship with Diabetes mellitus.
المؤلفون: Onikanni SA; Department of Chemical Sciences, Biochemistry Unit, 470822Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.; College of Medicine, Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan., Lawal B; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, 38032Taipei Medical University and Academia Sinica, Taipei.; Graduate Institute for Cancer Biology & Drug Discovery, College of Medical Science and Technology, 38032Taipei Medical University, Taipei., Bakare OS; Department of Biochemistry, 107994Adekunle Ajasin University, Akungba Akoko, Ondo State, Nigeria., Ajiboye BO; Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Ekiti State, Nigeria., Ojo OA; Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratory (PMTCB-RL), Department of Biochemistry, Bowen University, Iwo, 232101, Nigeria., Farasani A; Biomedical Research Unit, Medical Research Center, College of Applied Medical Sciences, 123285Jazan University, Jazan, Saudi Arabia.; Department of Medical Laboratory Technology, College of Applied Medical Sciences, 123285Jazan University, Jazan, Saudi Arabia., Kabrah SM; Department of Laboratory Medicine Faculty of Applied medical sciences, 48058Umm Al-Qura University, Kingdom of Saudi Arabia., Batiha GE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, 289643Damanhour University, Damanhour, AlBeheira, Egypt., Conte-Junior CA; Analytical and Molecular Laboratorial Center (CLAn), Institute of Chemistry (IQ), Federal University of Rio de Janeiro (UFRJ), Cidade Universitária, Rio de Janeiro, RJ, 21941-909, Brazil.
المصدر: Technology in cancer research & treatment [Technol Cancer Res Treat] 2022 Jan-Dec; Vol. 21, pp. 15330338221119743.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: SAGE Country of Publication: United States NLM ID: 101140941 Publication Model: Print Cited Medium: Internet ISSN: 1533-0338 (Electronic) Linking ISSN: 15330338 NLM ISO Abbreviation: Technol Cancer Res Treat Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015-: Thousand Oaks, CA : SAGE
Original Publication: Schenectady, NY : Adenine Press, c2002-
مواضيع طبية MeSH: Non-alcoholic Fatty Liver Disease*/complications , Non-alcoholic Fatty Liver Disease*/therapy , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/therapy , Liver Neoplasms*/complications, Humans ; Liver Cirrhosis/complications
مستخلص: A high increase witnessed in type II diabetes mellitus (T2DM) globally has increasingly posed a serious threat to global increases in liver cancer with the association between diabetes mellitus type II and the survival rate in liver cancer patients showing unstable findings. An increase in the development and progression of chronic liver disease from diabetes mellitus patients may be connected to cancer of the liver with several links such as Hepatitis B and C virus and heavy consumption of alcohol. The link between T2DM patients and liver cancer is centered on non-alcoholic fatty liver disease (NAFLD) which could be a serious threat globally if not clinically addressed. Several reports identified metformin treatment as linked to a lower risk of liver cancer prognosis while insulin treatment or sulphonylureas posed a serious threat. Mechanistically, the biological linkage between diabetes type II mellitus and liver cancer are still complex to understand with only the existence of a relationship between NAFLD and high level of energy intake and diabetes mellitus induces hepatic damage, increased liver weight thereby causes multiple pro-inflammatory cytokines that lead to the development of liver cancer. Therefore, this review gives an account of the pathophysiological importance of liver cancer position with T2DM, with the role of NAFLD as an important factor that bridges them.
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فهرسة مساهمة: Keywords: cirrhosis; cytokines; diabetes mellitus; liver cancer; prognosis; steatohepatitis
تواريخ الأحداث: Date Created: 20221219 Date Completed: 20221220 Latest Revision: 20230118
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9772979
DOI: 10.1177/15330338221119743
PMID: 36533882
قاعدة البيانات: MEDLINE
الوصف
تدمد:1533-0338
DOI:10.1177/15330338221119743