دورية أكاديمية
أعرض في EDS

Protective Effects of Kefir Against Unpredictable Chronic Stress Alterations in Mice Central Nervous System, Heart, and Kidney.

التفاصيل البيبلوغرافية
العنوان: Protective Effects of Kefir Against Unpredictable Chronic Stress Alterations in Mice Central Nervous System, Heart, and Kidney.
المؤلفون: Silva AO; Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, Brazil., Ribeiro JM; Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, Brazil., Patrocínio TB; Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, Brazil., Amorim GE; Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, Brazil., Pereira-Júnior AA; Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, Brazil., Ângelo ML; Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, Brazil., de Araújo Paula FB; Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, Brazil., de Mello Silva Oliveira N; José Do Rosário Velano University (UNIFENAS), Alfenas, MG, Brazil., Ruginsk SG; Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, Brazil., Antunes-Rodrigues J; University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Elias LLK; University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Dias MVS; Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, Brazil., Torres LH; Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, Brazil., Ceron CS; Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto (UFOP), Diogo de Vasconcelos, 122, 35400-000l, Ouro Preto, MG, Brazil. carla.ceron@ufop.edu.br.
المصدر: Probiotics and antimicrobial proteins [Probiotics Antimicrob Proteins] 2023 Apr; Vol. 15 (2), pp. 411-423. Date of Electronic Publication: 2022 Dec 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101484100 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1867-1314 (Electronic) Linking ISSN: 18671306 NLM ISO Abbreviation: Probiotics Antimicrob Proteins Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY. : Springer
مواضيع طبية MeSH: Antioxidants*/pharmacology , Kefir*, Mice ; Male ; Animals ; Catalase/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Matrix Metalloproteinase 2/pharmacology ; Corticosterone/pharmacology ; Thiobarbituric Acid Reactive Substances/pharmacology ; Oxidative Stress ; Glutathione/metabolism ; Kidney/metabolism ; Superoxide Dismutase ; Central Nervous System/metabolism ; Disease Models, Animal
مستخلص: Kefir is a probiotic mixture with anxiolytic and antioxidant properties. Chronic stress can lead to anxiety disorders and increase oxidative damage in organs such as the heart and kidney. In this study, we examined whether kefir ameliorates the anxiety-like behavior of mice submitted to chronic unpredictable stress (CUS) by modulating brain-derived neurotrophic factor (BDNF) and corticosterone levels and whether kefir modifies the oxidative parameters in the heart and kidney of mice. Male Swiss mice received kefir (0.3 mL/100 g/day) or milk for 30 days (gavage). On the 10th day, the mice were submitted to CUS. Behavioral analysis was performed using the elevated plus maze and forced swimming tests. BDNF levels were analyzed in brain tissues. Heart and kidney superoxide dismutase (SOD), catalase, glutathione (GSH), thiobarbituric acid reactive substances (TBARS), 3-nitrotyrosine, metalloproteinase-2 (MMP-2), and plasma corticosterone were evaluated. Kefir reverted the CUS-induced decrease in the time spent in the open arms, the increase in grooming frequency, and decrease in the head dipping frequency, but not the reduced immobility time. CUS decreased the cerebellum BDNF levels and increased corticosterone levels, which were restored by Kefir. Neither catalase and SOD activities nor GSH, TBARS, 3-nitrotyrosine, and MMP-2 were modified by CUS in the heart. In the kidney, CUS increased 3-nitrotyrosine and MMP-2. Kefir increased the antioxidant defense in the heart and kidney of control and CUS mice. These results suggest that kefir ameliorated CUS-induced anxiety-like behavior by modulating brain BDNF and corticosterone levels. Kefir also increased the antioxidant defense of mice heart and kidney.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
References: Lähdepuro A et al (2019) The impact of early life stress on anxiety symptoms in late adulthood. Sci Rep 9(1):1–13. https://doi.org/10.1038/s41598-019-40698-0. (PMID: 10.1038/s41598-019-40698-0)
Yang CR et al (2020) Antidepressant drugs correct the imbalance between proBDNF/p75NTR/sortilin and mature BDNF/TrkB in the brain of mice with chronic stress. Neurotox Res 37(1):171–182. https://doi.org/10.1007/s12640-019-00101-2. (PMID: 10.1007/s12640-019-00101-231493120)
Yu H, Tang M, Zeng Z, Huang S, Zheng X, Liu Z (2022) Suppressive effects of gelsemine on anxiety-like behaviors induced by chronic unpredictable mild stress in mice. Brain Sci. 12(2).  https://doi.org/10.3390/brainsci12020191.
Camuso S, La Rosa P, Fiorenza MT, Canterini S (2022) Pleiotropic effects of BDNF on the cerebellum and hippocampus: implications for neurodevelopmental disorders. Neurobiol Dis 163:105606. https://doi.org/10.1016/j.nbd.2021.105606. (PMID: 10.1016/j.nbd.2021.10560634974125)
Alzoubi KH, Abdel-Hafiz L, Khabour OF, El-Elimat T, Alzubi MA, Alali FQ (2020) Evaluation of the effect of hypericum triquetrifolium turra on memory impairment induced by chronic psychosocial stress in rats: role of BDNF. Drug Des Devel Ther 14:5299–5314. https://doi.org/10.2147/DDDT.S278153. (PMID: 10.2147/DDDT.S278153332993017720289)
Marin MT, Cruz FC, Planeta CS (2007) Chronic restraint or variable stresses differently affect the behavior, corticosterone secretion and body weight in rats. Physiol Behav 90(1):29–35. https://doi.org/10.1016/j.physbeh.2006.08.021. (PMID: 10.1016/j.physbeh.2006.08.02117023009)
Parul et al (2021) Chronic unpredictable stress negatively regulates hippocampal neurogenesis and promote anxious depression-like behavior via upregulating apoptosis and inflammatory signals in adult rats. Brain Res Bull 172(April):164–179. https://doi.org/10.1016/j.brainresbull.2021.04.017. (PMID: 10.1016/j.brainresbull.2021.04.01733895271)
Herman JP et al (2016) Regulation of the hypothalamic-pituitary-adrenocortical stress response. Comprehensive Physiology. Compr Physiol 6(2):603–621. https://doi.org/10.1002/cphy.c150015.Regulation. (PMID: 10.1002/cphy.c150015.Regulation270651634867107)
Mehta AJ (2016) Alcoholism and critical illness: a review. World J Crit Care Med 5(1):27. https://doi.org/10.5492/wjccm.v5.i1.27. (PMID: 10.5492/wjccm.v5.i1.27268558914733453)
Samarghandian S, Azimi-Nezhad M, Farkhondeh T, Samini F (2017) Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney. Biomed Pharmacother 87:223–229. https://doi.org/10.1016/j.biopha.2016.12.105. (PMID: 10.1016/j.biopha.2016.12.10528061405)
Şahin E, Gümüşlü S (2007) Immobilization stress in rat tissues: alterations in protein oxidation, lipid peroxidation and antioxidant defense system. Comp Biochem Physiol - C Toxicol Pharmacol 144(4):342–347. https://doi.org/10.1016/j.cbpc.2006.10.009. (PMID: 10.1016/j.cbpc.2006.10.00917157074)
Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39(1):44–84. https://doi.org/10.1016/j.biocel.2006.07.001. (PMID: 10.1016/j.biocel.2006.07.00116978905)
Rosa DD, Dias MMS, Grześkowiak ŁM, Reis SA, Conceição LL, Peluzio MDCG (2017) Milk kefir: nutritional, microbiological and health benefits. Nutr Res Rev 30(1):82–96. https://doi.org/10.1017/S0954422416000275. (PMID: 10.1017/S095442241600027528222814)
Mörkl S et al (2020) The role of nutrition and the gut-brain axis in psychiatry: a review of the literature. Neuropsychobiology 79(1):80–88. https://doi.org/10.1159/000492834. (PMID: 10.1159/000492834)
Noori N, Bangash M, Motaghinejad M, Hosseini P, Noudoost B (2014) Kefir protective effects against nicotine cessation-induced anxiety and cognition impairments in rats. Adv Biomed Res 3(1):251. https://doi.org/10.4103/2277-9175.146377. (PMID: 10.4103/2277-9175.146377255900294283242)
Chen H-L et al (2021) Kefir peptides exhibit antidepressant-like activity in mice through the BDNF/TrkB pathway. J Dairy Sci 104(6):6415–6430. https://doi.org/10.3168/jds.2020-19222. (PMID: 10.3168/jds.2020-1922233741171)
Pimenta FS et al (2018) Mechanisms of action of kefir in chronic cardiovascular and metabolic diseases. Cell Physiol Biochem 48(5):1901–1914. https://doi.org/10.1159/000492511. (PMID: 10.1159/00049251130092577)
Punaro GR et al (2014) Kefir administration reduced progression of renal injury in STZ-diabetic rats by lowering oxidative stress. Nitric Oxide - Biol Chem 37(1):53–60. https://doi.org/10.1016/j.niox.2013.12.012. (PMID: 10.1016/j.niox.2013.12.012)
Fahmy HA, Ismail AFM (2015) Gastroprotective effect of kefir on ulcer induced in irradiated rats. J Photochem Photobiol B Biol 144:85–93. https://doi.org/10.1016/j.jphotobiol.2015.02.009. (PMID: 10.1016/j.jphotobiol.2015.02.009)
Barboza KRM et al (2018) Gastroprotective effect of oral kefir on indomethacin-induced acute gastric lesions in mice: impact on oxidative stress. Life Sci 209(May):370–376. https://doi.org/10.1016/j.lfs.2018.08.035. (PMID: 10.1016/j.lfs.2018.08.03530120965)
Chen YH et al (2020) Anti-inflammatory, antioxidant, and antifibrotic effects of kefir peptides on salt-induced renal vascular damage and dysfunction in aged stroke-prone spontaneously hypertensive rats. Antioxidants 9(9):1–18. https://doi.org/10.3390/antiox9090790. (PMID: 10.3390/antiox9090790)
Erdogan FS, Ozarslan S, Guzel-Seydim ZB, Kök Taş T (2019) The effect of kefir produced from natural kefir grains on the intestinal microbial populations and antioxidant capacities of Balb/c mice. Food Res Int 115(June 2018):408–413.  https://doi.org/10.1016/j.foodres.2018.10.080.
Strada R et al (2010) Microbial profile of a kefir sample preparations – grains in natura and lyophilized and fermented suspension. Ciência e Tecnol Aliment 30(4):1022–1026. (PMID: 10.1590/S0101-20612010000400029)
Brasil GA et al (2018) The benefits of soluble non-bacterial fraction of kefir on blood pressure and cardiac hypertrophy in hypertensive rats are mediated by an increase in baroreflex sensitivity and decrease in angiotensin-converting enzyme activity. Nutrition 51–52:66–72. https://doi.org/10.1016/j.nut.2017.12.007. (PMID: 10.1016/j.nut.2017.12.00729605766)
Lepsch LB, Gonzalo LA, Magro FJB, Delucia R, Scavone C, Planeta CS (2005) Exposure to chronic stress increases the locomotor response to cocaine and the basal levels of corticosterone in adolescent rats. Addict Biol 10(3):251–256. https://doi.org/10.1080/13556210500269366. (PMID: 10.1080/1355621050026936616109586)
Cruz FC, Marin MT, Leão RM, Planeta CS (2012) Behavioral and neuroendocrine effects of the exposure to chronic restraint or variable stress in early adolescent rats. Int J Dev Neurosci 30(1):19–23. https://doi.org/10.1016/j.ijdevneu.2011.10.005. (PMID: 10.1016/j.ijdevneu.2011.10.00522027619)
Pellow S, Chopin P, File SE, Briley M (1985) Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14(3):149–167. https://doi.org/10.1016/0165-0270(85)90031-7. (PMID: 10.1016/0165-0270(85)90031-72864480)
Almeida CAF et al (2021) Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice. Behav Brain Res 416(August):2022. https://doi.org/10.1016/j.bbr.2021.113546. (PMID: 10.1016/j.bbr.2021.113546)
Dalvi A, Rodgers RJ (1999) Behavioral effects of diazepam in the murine plus-maze: flumazenil antagonism of enhanced head dipping but not the disinhibition of open-arm avoidance. Pharmacol Biochem Behav 62(4):727–734. https://doi.org/10.1016/S0091-3057(98)00220-2. (PMID: 10.1016/S0091-3057(98)00220-210208379)
Arakawa H (2021) Implication of the social function of excessive self-grooming behavior in BTBR T+ltpr3tf/J mice as an idiopathic model of autism. Physiol Behav 237:113432. https://doi.org/10.1016/j.physbeh.2021.113432. (PMID: 10.1016/j.physbeh.2021.11343233901528)
Reimer AE, de Oliveira AR, Diniz JB, Hoexter MQ, Chiavegatto S, Brandão ML (2015) Rats with differential self-grooming expression in the elevated plus-maze do not differ in anxiety-related behaviors. Behav Brain Res 292:370–380. https://doi.org/10.1016/j.bbr.2015.06.036. (PMID: 10.1016/j.bbr.2015.06.03626142783)
Kliethermes CL, Crabbe JC (2006) Pharmacological and genetic influences on hole-board behaviors in mice. Pharmacol Biochem Behav 85(1):57–65. https://doi.org/10.1016/j.pbb.2006.07.007. (PMID: 10.1016/j.pbb.2006.07.00716949140)
Kalueff AV, Stewart AM, Song C, Berridge KC, Graybiel AM, Fentress JC (2016) Neurobiology of rodent self-grooming and its value for translational neuroscience. Nat Rev Neurosci 17(1):45–59. https://doi.org/10.1038/nrn.2015.8. (PMID: 10.1038/nrn.2015.826675822)
Can A, Dao DT, Arad M, Terrillion CE, Piantadosi SC, Gould TD (2011) The mouse forced swim test. J Vis Exp 58:4–8. https://doi.org/10.3791/3638. (PMID: 10.3791/3638)
Do Valle GT, Ricci ST, Silva AO, Tirapelli CR, Ceron CS (2020) Ethanol consumption increases renal dysfunction and mortality in a mice model of sub-lethal sepsis. Can J Physiol Pharmacol pp. 1–35.  https://doi.org/10.1139/cjpp-2020-0564 .
Aebi H (1984) [13] Catalase in vitro. Methods Enzymol 105:121–126.  https://doi.org/10.1016/S0076-6879(84)05016-3.
Simplicio JA, Resstel LB, Tirapelli DPC, D’Orléans-Juste P, Tirapelli CR (2015) Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment. Vascul Pharmacol 73:124–137. https://doi.org/10.1016/j.vph.2015.06.015. (PMID: 10.1016/j.vph.2015.06.01526141931)
Hu C et al (2017) Re-evaluation of the interrelationships among the behavioral tests in rats exposed to chronic unpredictable mild stress. PLoS ONE 12(9):1–15. https://doi.org/10.1371/journal.pone.0185129. (PMID: 10.1371/journal.pone.0185129)
Mehta V, Parashar A, Udayabanu M (2017) Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stress. Physiol Behav 171:69–78. https://doi.org/10.1016/j.physbeh.2017.01.006. (PMID: 10.1016/j.physbeh.2017.01.00628069457)
López-López AL, Jaime HB, Villanueva MD, Padilla MB, Palacios GV, Aguilar FJ (2016) Chronic unpredictable mild stress generates oxidative stress and systemic inflammation in rats. Physiol Behav 161(186):15–23.  https://doi.org/10.1016/j.physbeh.2016.03.017.
Liu X et al (2021) Impact of inosine on chronic unpredictable mild stress-induced depressive and anxiety-like behaviors with the alteration of gut microbiota. Front Cell Infect Microbiol 11(September):1–11. https://doi.org/10.3389/fcimb.2021.697640. (PMID: 10.3389/fcimb.2021.697640)
Marangon PB, Silva LE, Rorato R, Gomiero Alves P, Antunes‐Rodrigues J, Elias LL (2014) Oestradiol modulates the effects of leptin on energy homeostasis by corticotrophin-releasing factor type 2 receptor. J Neuroendocrinol 26(11):796–804.  https://doi.org/10.1111/jne.12192.
da Silva Marques JG et al (2021) Adaptogenic effects of curcumin on depression induced by moderate and unpredictable chronic stress in mice. Behav Brain Res 399.  https://doi.org/10.1016/j.bbr.2020.113002 .
Li H, Wang P, Huang L, Li P, Zhang D (2019) Effects of regulating gut microbiota on the serotonin metabolism in the chronic unpredictable mild stress rat model. Neurogastroenterol Motil 31(10):1–13. https://doi.org/10.1111/nmo.13677. (PMID: 10.1111/nmo.13677)
Schmidt HD, Duman RS (2010) Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models. Neuropsychopharmacology 35(12):2378–2391. https://doi.org/10.1038/npp.2010.114. (PMID: 10.1038/npp.2010.114206864542955759)
Govindarajan A et al (2006) Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects. Proc Natl Acad Sci U S A 103(35):13208–13213. https://doi.org/10.1073/pnas.0605180103. (PMID: 10.1073/pnas.0605180103169241031559778)
Lin L, Herselman MF, Zhou XF, Bobrovskaya L (2022) Effects of corticosterone on BDNF expression and mood behaviours in mice. Physiol Behav vol. 247(November 2021):113721.  https://doi.org/10.1016/j.physbeh.2022.113721.
Liu X, Cao S, Zhang X (2015) Modulation of gut microbiota-brain axis by probiotics, prebiotics, and diet. J Agric Food Chem 63(36):7885–7895. https://doi.org/10.1021/acs.jafc.5b02404. (PMID: 10.1021/acs.jafc.5b0240426306709)
Li Y, Peng C, Guo X, You JJ, Yadav HP (2015) Expression of brain-derived neurotrophic factor and tyrosine kinase B in cerebellum of poststroke depression rat model. Chin Med J (Engl) 128(21):2926–2931. https://doi.org/10.4103/0366-6999.168058. (PMID: 10.4103/0366-6999.16805826521792)
Ishola IO, Olubodun-Obadun TG, Bakre OA, Ojo ES, Adeyemi OO (2022) Kolaviron ameliorates chronic unpredictable mild stress-induced anxiety and depression: involvement of the HPA axis, antioxidant defense system, cholinergic, and BDNF signaling. Drug Metab Pers Ther. https://doi.org/10.1515/dmpt-2021-0125. (PMID: 10.1515/dmpt-2021-012535377569)
Li J, He P, Zhang J, Li N (2021) Orcinol glucoside improves the depressive-like behaviors of perimenopausal depression mice through modulating activity of hypothalamic–pituitary–adrenal/ovary axis and activating BDNF-TrkB-CREB signaling pathway. Phyther Res 35(10):5795–5807. https://doi.org/10.1002/ptr.7237. (PMID: 10.1002/ptr.7237)
Thakare VN, Patil RR, Oswal RJ, Dhakane VD, Aswar MK, Patel BM (2018) Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. J Psychopharmacol 32(2):223–235. https://doi.org/10.1177/0269881117742666. (PMID: 10.1177/026988111774266629215318)
Wang D et al (2022) Tryptophan-rich diet ameliorates chronic unpredictable mild stress induced depression- and anxiety-like behavior in mice: the potential involvement of gut-brain axis. Food Res Int 157:111289.  https://doi.org/10.1016/j.foodres.2022.111289.
Luna RA, Foster JA (2015) Gut brain axis: diet microbiota interactions and implications for modulation of anxiety and depression. Curr Opin Biotechnol 32(Figure 1):35–41.  https://doi.org/10.1016/j.copbio.2014.10.007.
O’Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF (2015) Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res 277:32–48. https://doi.org/10.1016/j.bbr.2014.07.027. (PMID: 10.1016/j.bbr.2014.07.02725078296)
Marrocco J et al (2017) A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice. Nat Commun 8(1):1–15. https://doi.org/10.1038/s41467-017-01014-4. (PMID: 10.1038/s41467-017-01014-4)
Furman O, Tsoory M, Chen A (2022) Differential chronic social stress models in male and female mice. Eur J Neurosci 55(9–10):2777–2793. https://doi.org/10.1111/ejn.15481. (PMID: 10.1111/ejn.1548134587653)
Sánchez-Solís CN, Cuevas-Romero E, Munoz A, Cervantes-Rodríguez M, Rodríguez-Antolín J, Nicolás-Toledo L (2018) Morphometric changes and AQP2 expression in kidneys of young male rats exposed to chronic stress and a high-sucrose diet. Biomed Pharmacother 105(June):1098–1105. https://doi.org/10.1016/j.biopha.2018.06.086. (PMID: 10.1016/j.biopha.2018.06.08630021346)
Zhu LJ, Zhang CC, Chen C (2021) Research progress on the vesicle cycle and neurological disorders. J Pharm Pharm Sci 24(9):400–412. https://doi.org/10.18433/jpps31458. (PMID: 10.18433/jpps3145834343470)
Yener AU et al (2015) Effects of kefir on ischemia-reperfusion injury. Eur Rev Med Pharmacol Sci 19(5):887–896. (PMID: 25807443)
Mert H, Yilmaz H, Irak K, Yildirim S, Mert N (2018) Investigation of the protective effect of kefir against isoproterenol induced myocardial infarction in rats. Korean J Food Sci Anim Resour 38(2):259–272. https://doi.org/10.5851/kosfa.2018.38.2.259. (PMID: 10.5851/kosfa.2018.38.2.259298052765960824)
Kandasamy AD, Chow AK, Ali MAM, Schulz R (2010) Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix. Cardiovasc Res 85(3):413–423. https://doi.org/10.1093/cvr/cvp268. (PMID: 10.1093/cvr/cvp26819656780)
Cavdar Z et al (2017) Protective effects of taurine against renal ischemia/reperfusion injury in rats by inhibition of gelatinases, MMP-2 and MMP-9, and p38 mitogen-activated protein kinase signaling. Biotech Histochem 92(7):524–535. https://doi.org/10.1080/10520295.2017.1367033. (PMID: 10.1080/10520295.2017.136703328895768)
Hu JB et al (2018) An E-selectin targeting and MMP-2-responsive dextran-curcumin polymeric prodrug for targeted therapy of acute kidney injury. Biomater Sci 6(12):3397–3409. https://doi.org/10.1039/c8bm00813b. (PMID: 10.1039/c8bm00813b30371703)
Kim H et al (2019) Plant-based diets and incident CKD and kidney function. Clin J Am Soc Nephrol 14(5):682–691. https://doi.org/10.2215/CJN.12391018. (PMID: 10.2215/CJN.12391018310239286500948)
Ferraro PM, Bargagli M, Trinchieri A, Gambaro G, Assimos DG (2020) Re: risk of kidney stones: influence of dietary factors, dietary patterns, and vegetarian-vegan diets. J Urol 204(3):612. https://doi.org/10.1097/JU.0000000000001173.01. (PMID: 10.1097/JU.0000000000001173.01)
Valim A, Carpes LS, Nicoletto BB (2022) Effect of vegetarian diets on renal function in patients with chronic kidney disease under non-dialysis treatment: a scoping review. Brazilian J Nephrol 44(3).  https://doi.org/10.1590/2175-8239-jbn-2021-0126.
معلومات مُعتمدة: 406177/2016-3 Conselho Nacional de Desenvolvimento Científico e Tecnológico; PPM-00383-18 Fundação de Amparo à Pesquisa do Estado de Minas Gerais
فهرسة مساهمة: Keywords: Anxiety-like behavior; BDNF; Heart damage; Kefir; Kidney damage; Oxidative stress; Unpredictable chronic stress
المشرفين على المادة: 0 (Antioxidants)
EC 1.11.1.6 (Catalase)
0 (Brain-Derived Neurotrophic Factor)
EC 3.4.24.24 (Matrix Metalloproteinase 2)
W980KJ009P (Corticosterone)
0 (Thiobarbituric Acid Reactive Substances)
GAN16C9B8O (Glutathione)
EC 1.15.1.1 (Superoxide Dismutase)
تواريخ الأحداث: Date Created: 20221219 Date Completed: 20230321 Latest Revision: 20230330
رمز التحديث: 20231215
DOI: 10.1007/s12602-022-10031-9
PMID: 36534210
قاعدة البيانات: MEDLINE
الوصف
تدمد:1867-1314
DOI:10.1007/s12602-022-10031-9