دورية أكاديمية
The Impact of Sonothrombolysis on Left Ventricular Diastolic Function and Left Atrial Mechanics Preventing Left Atrial Remodeling in Patients With ST Elevation Acute Myocardial Infarction.
| العنوان: | The Impact of Sonothrombolysis on Left Ventricular Diastolic Function and Left Atrial Mechanics Preventing Left Atrial Remodeling in Patients With ST Elevation Acute Myocardial Infarction. |
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| المؤلفون: | Chiang HP; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil; Fleury Group, São Paulo, Brazil. Electronic address: hsu.pochiang@gmail.com., Aguiar MOD; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil; Fleury Group, São Paulo, Brazil., Tavares BG; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil; Fleury Group, São Paulo, Brazil., Rosa VEE; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Gomes SB; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Oliveira MT Jr; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Soeiro A; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Nicolau JC; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Ribeiro HB; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Sbano JC; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil; Fleury Group, São Paulo, Brazil., Rochitte CE; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Filho RK; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Ramires JAF; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Porter TR; University of Nebraska Medical Center, Omaha, Nebraska., Mathias W Jr; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil; Fleury Group, São Paulo, Brazil., Tsutsui JM; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil; Fleury Group, São Paulo, Brazil. |
| المصدر: | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography [J Am Soc Echocardiogr] 2023 May; Vol. 36 (5), pp. 504-513. Date of Electronic Publication: 2022 Dec 16. |
| نوع المنشور: | Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mosby-Year Book Country of Publication: United States NLM ID: 8801388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6795 (Electronic) Linking ISSN: 08947317 NLM ISO Abbreviation: J Am Soc Echocardiogr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: St. Louis Mo : Mosby-Year Book Original Publication: St. Louis, Mo. : C.V. Mosby Co., [c1988- |
| مواضيع طبية MeSH: | ST Elevation Myocardial Infarction*/diagnosis , ST Elevation Myocardial Infarction*/therapy , Percutaneous Coronary Intervention*/methods , Atrial Fibrillation* , Atrial Remodeling*, Humans ; Female ; Male ; Heart Atria/diagnostic imaging ; Ventricular Function, Left ; Ventricular Remodeling |
| مستخلص: | Background: The diagnostic ultrasound-guided high mechanical index impulses during an intravenous microbubble infusion (sonothrombolysis) improve myocardial perfusion in acute ST segment elevation myocardial infarction, but its effect on left ventricular diastolic dysfunction (DD), left atrial (LA) mechanics and remodeling is unknown. We assessed the effect of sonothrombolysis on DD grade and LA mechanics. Methods: One hundred patients (59 ± 10 years; 34% women) were randomized to receive either high mechanical index impulses plus percutaneous coronary intervention (PCI) (therapy group) or PCI only (control group) (n = 50 in each group). Diastolic dysfunction grade and LA mechanics were assessed immediately before and after PCI and at 48 to 72 hours, 1 month, and 6 months of follow-up. Diastolic dysfunction grades were classified as grades I, II, and III. The LA mechanics was obtained by two-dimensional speckle-tracking echocardiography-derived global longitudinal strain (GLS). Results: As follow-up time progressed, increased DD grade was observed more frequently in the control group than in the therapy group at 1 month and 6 months of follow-up (all P < .05). The LA-GLS values were incrementally higher in the therapy group when compared with the control group at 48 to 72 hours, 24.0% ± 7.3% in the therapy group versus 19.6% ± 7.2% in the control group, P = .005; at 1 month, 25.3% ± 6.3% in the therapy group versus 21.5% ± 8.3% in the control group, P = .020; and at 6 months, 26.2% ± 8.7% in the therapy group versus 21.6% ± 8.5% in the control group, P = .015. The therapy group was less likely to experience LA remodeling (odds ratio, 2.91 [1.10-7.73]; P = .03). LA-GLS was the sole predictor of LA remodeling (odds ratio, 0.79 [0.67-0.94]; P = .006). Conclusion: Sonothrombolysis is associated with better DD grade and LA mechanics, reducing LA remodeling. (Copyright © 2022 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: J Am Soc Echocardiogr. 2023 May;36(5):514-515. (PMID: 36690514) |
| فهرسة مساهمة: | Keywords: Acute myocardial infarction; Left atrial remodeling; Left atrial strain; Left ventricular diastolic dysfunction; Sonothrombolysis |
| تواريخ الأحداث: | Date Created: 20221219 Date Completed: 20230508 Latest Revision: 20230519 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.echo.2022.12.010 |
| PMID: | 36535625 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1097-6795 |
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| DOI: | 10.1016/j.echo.2022.12.010 |