دورية أكاديمية
Hamster polyomavirus-associated T-cell lymphomas in Syrian hamsters ( Mesocricetus auratus ).
| العنوان: | Hamster polyomavirus-associated T-cell lymphomas in Syrian hamsters ( Mesocricetus auratus ). |
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| المؤلفون: | Ito S; The University of Tokyo, Tokyo, Japan., Chambers JK; The University of Tokyo, Tokyo, Japan., Son NV; The University of Tokyo, Tokyo, Japan.; Vietnam National University of Agriculture, Hanoi, Vietnam., Kita C; Shikoku Cytopathological Laboratory, Takamatsu-shi, Japan., Ise KI; Yoshizuka Pet Clinic, Fukuoka, Japan., Miwa Y; Miwa Exotic Animal Hospital, Tokyo, Japan.; Vision Vets Group Lab, Tokyo, Japan., Nakayama H; Vision Vets Group Lab, Tokyo, Japan., Uchida K; The University of Tokyo, Tokyo, Japan. |
| المصدر: | Veterinary pathology [Vet Pathol] 2023 Mar; Vol. 60 (2), pp. 267-275. Date of Electronic Publication: 2022 Dec 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: United States NLM ID: 0312020 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1544-2217 (Electronic) Linking ISSN: 03009858 NLM ISO Abbreviation: Vet Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2010- : Thousand Oaks, CA : Sage Original Publication: 1971- : Basel : New York : Karger. |
| مواضيع طبية MeSH: | Polyomavirus*/genetics , Polyomavirus Infections*/pathology , Polyomavirus Infections*/veterinary , Lymphoma, T-Cell*/veterinary , Skin Neoplasms*/veterinary , Lymphoma, T-Cell, Cutaneous*/veterinary , Rodent Diseases*, Cricetinae ; Animals ; Mesocricetus |
| مستخلص: | Hamster polyomavirus (HaPyV) infection has been associated with lymphomas in Syrian hamsters. In the present study, 14 cases of lymphoma in pet Syrian hamsters were pathologically examined and the involvement of HaPyV was investigated. Among 14 cases, 11 were abdominal and 3 were cutaneous lymphomas. The average ages of hamsters with abdominal lymphoma and cutaneous lymphoma were 7 months (range: 4-12 months) and 14 months (range: 6-23 months), respectively. Histologically, abdominal lymphomas were characterized by the diffuse growth of tumor cells with intermediate or large nuclei, low mitotic rates, the presence of tingible body macrophages, and the T-cell immunophenotype. Furthermore, 4/11 abdominal lymphomas were immunopositive for T-cell intracellular antigen-1, suggesting cytotoxic T-cell lymphomas. Cutaneous lymphomas were diagnosed as nonepitheliotropic T-cell lymphoma. Polymerase chain reaction (PCR) detected HaPyV DNA in 12/14 samples, and a sequence analysis of PCR amplicons confirmed >99% nucleotide identity to the published HaPyV sequences. In situ hybridization (ISH) for HaPyV DNA resulted in diffuse nuclear signals within tumor cells in 10/14 cases. Consistent with previous findings, all HaPyV-associated lymphomas were observed in the abdominal cavity of young hamsters. Polymerase chain reaction and ISH were useful for identifying the involvement of HaPyV in lymphomas, and ISH results indicated the presence of episomal HaPyV in neoplastic lymphocytes. The present study suggests that HaPyV infection is highly involved in abdominal lymphomas in young pet Syrian hamsters in Japan and provides diagnostic information on HaPyV-associated lymphoma. |
| فهرسة مساهمة: | Keywords: Syrian hamster (Mesocricetus auratus); cricetinae; exotic pets; lymphoma; neoplasms; polyomavirus |
| تواريخ الأحداث: | Date Created: 20221220 Date Completed: 20230228 Latest Revision: 20230307 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1177/03009858221140823 |
| PMID: | 36537739 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1544-2217 |
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| DOI: | 10.1177/03009858221140823 |